Physical Activity Regulates and Mediates the Signaling Pathway and Pathophysiological Mechanisms of the Neuroinflammation and Neurodegenerative DOI Open Access
Navid Abedpoor, Fatemeh Hajibabaie

Asian Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 15(4)

Published: Oct. 23, 2024

Context: The correlation between neuroinflammation and neurodegenerative disorders has been extensively documented. Elevated levels of inflammatory cytokines in the bloodstream have demonstrated to impair memory function heighten susceptibility disorders. Furthermore, elevated quantities reactive oxygen species (ROS) body, known as oxidative stress, exacerbate illnesses negatively affect learning memory. Neuroprotection prevents neuronal cell death by intervening blocking pathogenetic process that leads cellular malfunction death. Methods: We evaluated several studies WEB SCIENCE, SCOPUS, PubMed. we identified central genes signaling pathways associated with neurogenesis, neural system, neuroplasticity through data mining, a literature review artificial intelligence, an in-silico study. Results: Physical exercise (PE) benefits various physiological systems, including nervous system. beneficial impacts physical activity on cognitive performance, well-being, safeguarding neurons against different brain injuries are research PE is powerful non-pharmacological intervention enhances function, memory, while decreasing likelihood developing Additionally, engaging moderate does not result extreme fatigue impact reducing inflammation promoting antioxidant effects. According hormesis theory, inactivity overtraining can decrease function. Conclusions: In summary, combination aerobic exercise, HIIT, resistance training, performed at appropriate intensities, most for neuroprotection health. Regular engagement these activities help mitigate risk diseases enhance overall

Language: Английский

Astrocyte metabolism and signaling pathways in the CNS DOI Creative Commons

Yong-Mei Zhang,

Yingbei Qi,

Ya-nan Gao

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 4, 2023

Astrocytes comprise half of the cells in central nervous system and play a critical role maintaining metabolic homeostasis. Metabolic dysfunction astrocytes has been indicated as primary cause neurological diseases, such depression, Alzheimer’s disease, epilepsy. Although functionalities are well known, their relationship to disorders is poorly understood. The ways which regulate metabolism glucose, amino acids, lipids have all implicated diseases. Metabolism also exhibited significant influence on neuron functionality brain’s neuro-network. In this review, we focused processes present astrocytes, most notably glucose pathway, fatty acid amino-acid pathway. For metabolism, glycolysis pentose-phosphate oxidative phosphorylation followed oxidation, ketone body sphingolipid metabolism. summarized neurotransmitter serine kynurenine pathways. This review will provide an overview functional changes astrocyte overall perspective current treatment therapy for disorders.

Language: Английский

Citations

42
Exploring the microbiota-gut-brain axis: impact on brain structure and function DOI Creative Commons

Lidya K. Yassin,

Mohammed M. Nakhal,

Alreem Alderei

et al.

Frontiers in Neuroanatomy, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 12, 2025

The microbiota-gut-brain axis (MGBA) plays a significant role in the maintenance of brain structure and function. MGBA serves as conduit between CNS ENS, facilitating communication emotional cognitive centers via diverse pathways. In initial stages this review, we will examine way how affects neurogenesis, neuronal dendritic morphology, axonal myelination, microglia structure, blood barrier (BBB) permeability, synaptic structure. Furthermore, review potential mechanistic pathways neuroplasticity through influence. short-chain fatty acids (SCFAs) play pivotal MGBA, where they can modify BBB. We therefore discuss SCFAs influence microglia, neuronal, astrocyte function, well their disorders such Alzheimer’s disease (AD), Parkinson’s (PD). Subsequently, technical strategies employed to study interactions, including using germ-free (GF) animals, probiotics, fecal microbiota transplantation (FMT), antibiotics-induced dysbiosis. Finally, particular bacterial strains affect By gaining deeper understanding it may be possible facilitate research into microbial-based pharmacological interventions therapeutic for neurological diseases.

Language: Английский

Citations

2
Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling DOI Creative Commons
Dirk M. Hermann, Luca Peruzzotti‐Jametti, Bernd Giebel

et al.

Brain, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 28, 2023

Abstract Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles that convey complex signals between cells. EVs of different cellular sources capable inducing striking therapeutic responses in neurological disease models. Differently from pharmacological compounds act by modulating defined signalling pathways, EV-based therapeutics possess multiple abilities via a variety effectors, thus allowing the modulation processes may have very potent effects on brain tissue recovery. When applied vivo experimental models diseases, revealed remarkable immune responses, cell metabolism and neuronal plasticity. This multimodal neuroimmune networks profoundly influences highly synergistic context-dependent way. Ultimately, EV-mediated restoration functions helps to set stage for With this review we first outline current understanding mechanisms action EVs, describing how released various identify their targets recipient Then, applicable key conditions such as stroke, sclerosis neurodegenerative diseases presented. Pathways deserve attention specific contexts discussed. We subsequently showcase considerations about EV biodistribution delineate genetic engineering strategies aiming at enhancing uptake signalling. By sketching broad view EV-orchestrated plasticity recovery, finally define possible future clinical applications propose necessary information be provided ahead trials. Our goal is provide steppingstone can used critically discuss next generation diseases.

Language: Английский

Citations

26
Novel treatments for anorexia nervosa: Insights from neuroplasticity research DOI Creative Commons
Johanna Louise Keeler, Carol Kan, Janet Treasure

et al.

European Eating Disorders Review, Journal Year: 2023, Volume and Issue: 32(6), P. 1069 - 1084

Published: Oct. 12, 2023

Treatment for anorexia nervosa (AN) remains challenging; there are no approved psychopharmacological interventions and psychotherapeutic strategies have variable efficacy. The investigation of evidence-based treatments has so far been compounded by an underdeveloped understanding into the neurobiological changes associated with acute stages AN. There is converging evidence deficiencies in neuroplasticity

Language: Английский

Citations

21
Neuroplasticity in the transition from acute to chronic pain DOI Creative Commons

Qingbiao Song,

E Sihan,

Zhiyu Zhang

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: unknown, P. e00464 - e00464

Published: Oct. 1, 2024

Language: Английский

Citations

4
Prevention and early intervention strategies for perinatal mental health disorders mediated by neuroimmune modulation and anti-inflammatory mechanisms through non-invasive transcranial magnetic stimulation: A narrative review DOI Creative Commons
Yoshihiro Noda,

Shinichiro Nakajima

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100103 - 100103

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring Endothelial Cell Dysfunction’s Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications DOI
Wahid Shah, Yuanyuan Gong, Xinhan Qiao

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

0
Neuron-to-glia and glia-to-glia signaling directs critical period experience-dependent synapse pruning DOI Creative Commons

Nichalas Nelson,

Vanessa Miller, Kendal Broadie

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 18, 2025

Experience-dependent glial synapse pruning plays a pivotal role in sculpting brain circuit connectivity during early-life critical periods of development. Recent advances suggest layered cascade intercellular communication between neurons and phagocytes orchestrates this precise, targeted elimination. We focus here on studies from the powerful Drosophila forward genetic model, with reference to complementary findings mouse work. present both neuron-to-glia glia-to-glia signaling pathways directing experience-dependent pruning. discuss putative hierarchy secreted long-distance cues cell surface short-distance that act sequentially orchestrate glia activation, infiltration, target recognition, engulfment, then phagocytosis for Ligand-receptor partners mediating these stages different contexts are discussed recent studies. Signaling include phospholipids, small neurotransmitters, insulin-like peptides, proteins. Conserved receptors ligands discussed, together mechanisms where receptor identity remains unknown. Potential proposed tight temporal-restriction heightened elimination periods, as well potential means re-open such plasticity at maturity.

Language: Английский

Citations

0
The Role of Microglia in Perioperative Pain and Pain Treatment: Recent Advances in Research DOI Creative Commons
Shuyan Shi, Xingrui Gong

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(2)

Published: Jan. 25, 2025

Microglia play a crucial role in monitoring the microenvironment of central nervous system. Over past decade, microglia field pain has gradually been unraveled. activation not only releases proinflammatory factors that enhance nociceptive signaling, but also participates resolving pain. Opioids induce activation, which enhances phagocytic activity and release neurotoxic substances. Conversely, reduces opioid efficacy results tolerance. The application research to clinical management drug development is promising challenging area. Microglia-targeted therapies may provide new avenues for management.

Language: Английский

Citations

0
The Impact of Neuroglia on Vestibular Disorders: Insights and Implications DOI Creative Commons
Melissa Castillo‐Bustamante, Andrés Felipe Herrón-Arango,

María José Bedoya

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: March 1, 2025

Vestibular disorders significantly affect individuals by impairing balance, spatial orientation, and quality of life. Despite the focus on neuronal mechanisms, emerging research emphasizes importance neuroglia—astrocytes, microglia, oligodendrocytes, Schwann cells—in onset, progression, resolution these conditions. This narrative review explores roles neuroglia in vestibular disorders, including migraines unilateral bilateral vestibulopathies. It discusses established facts, challenges, future perspectives, offering insights into their pathophysiological therapeutic implications, limitations current research. By understanding interplay between function, this aims to advance diagnostic treatment strategies for

Language: Английский

Citations

0