Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention DOI Creative Commons
Teresita Alzate Yepes, Lorena Pérez-Palacio, Estefanía Martínez

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4322 - 4322

Published: May 24, 2023

Colorectal cancer (CRC) is the third most common worldwide and its incidence expected to increase by almost 80% 2030. CRC apparition related poor diet, mainly due low consumption of phytochemicals present in fruits vegetables. Hence, this paper reviews promising literature, presenting scientific evidence regarding potential chemopreventive effects. Moreover, reveals structure action mechanisms that these are involved in. The review vegetables rich such as carrots green leafy vegetables, well some pineapple, citrus fruits, papaya, mango, Cape gooseberry, have antioxidant, anti-inflammatory, properties can promote a healthy colonic environment. Fruits daily diet antitumor regulating cell signaling and/or proliferation pathways. plant products recommended reduce risk CRC.

Language: Английский

p-Coumaric Acid: A Naturally Occurring Chemical with Potential Therapeutic Applications DOI
Jasleen Kaur,

Ramandeep Kaur

Current Organic Chemistry, Journal Year: 2022, Volume and Issue: 26(14), P. 1333 - 1349

Published: July 1, 2022

Abstract: Coumaric acid is a hydroxy derivative of cinnamic with three different isomers (ortho, meta and para). Its most commonly available form p-coumaric acid. p-Coumaric i.e., 4-hydroxycinnamic potent phenolic compound found to exist naturally in various plants, cereals, fruits vegetables. It one the major constituent compounds polymer lignin lignocellulosic materials. Various natural synthetic derivatives pcoumaric have been reported literature. Different extraction methods including conventional such as solvent extraction, acidification, alkaline etc. recent approaches clip-off method, sugaring out soft microwave for its qualitative quantitative determination plant materials investigated by researchers. This paper has discussed synthesis amides, esters, aldehydes, polymers, copolymers. possess bioactive properties antioxidant, antimicrobial, anticancer, antiarthritic, anti-inflammatory, gout prevention, anti-diabetic, anti-melanogenic, skin regeneration, gastroprotective, anti-ulcer, cardioprotective, hepatoprotective, reno-protective, bone formation, anti-angiogenic anti-platelet Owing this huge potential, could be incorporated edible food products, pharmaceutical cosmetics, More studies are required evaluate their compatability these products. To best our knowledge, first review discussing occurrence, derivatives, therapeutic applications

Language: Английский

Citations

41

Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: A state-of-the-art review DOI
Fan Xie, Wanling Yang, Mingxia Xing

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 140, P. 104171 - 104171

Published: Sept. 12, 2023

Language: Английский

Citations

41

Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate DOI
Shuling Zhang, Bingyong Mao, Shumao Cui

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(19), P. 6546 - 6566

Published: Feb. 2, 2023

Epigallocatechin gallate (EGCG), a typical flavone-3-ol polyphenol containing eight free hydroxyl groups, is associated with variety of bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, and antibacterial activities. However, the poor bioavailability EGCG restricts its use. In this review, we discuss processes involved in absorption metabolism EGCG, focus on metabolic interactions gut microbiota. Next, summarize bioactivities some key metabolites, describe biotransformation by different microorganisms, catabolism specific bacteria. A deeper understanding absorption, metabolism, may enable disease-preventive therapeutic properties to be better utilized. This review provides theoretical basis for further development utilization metabolites improving microbiota physiological health.

Language: Английский

Citations

33

Interaction between Dietary Fibre and Bioactive Compounds in Plant By-Products: Impact on Bioaccessibility and Bioavailability DOI Creative Commons
Vanesa Núñez-Gómez, Rocío González‐Barrio, María Jesús Periago

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 976 - 976

Published: April 21, 2023

In Europe, around 31 million tonnes of food by-products are generated during primary production and trade. The management these may cause a negative impact, both at the economic environmental levels, for industry society. this regard, taking into consideration that retain dietary fibre compositions bioactive compounds starting materials, plant agro-industries have an interest in advantage them, from nutritional point view. Therefore, review evaluates role as well potential interactions components their implications health, since associated with reach colon, where they can be metabolised postbiotic compounds, providing important health benefits (prebiotic, antioxidant, anti-inflammatory, etc.). Consequently, aspect, on which there few studies, is very relevant must considered revaluation to obtain new ingredients processing improved technological properties.

Language: Английский

Citations

28

Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention DOI Creative Commons
Teresita Alzate Yepes, Lorena Pérez-Palacio, Estefanía Martínez

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4322 - 4322

Published: May 24, 2023

Colorectal cancer (CRC) is the third most common worldwide and its incidence expected to increase by almost 80% 2030. CRC apparition related poor diet, mainly due low consumption of phytochemicals present in fruits vegetables. Hence, this paper reviews promising literature, presenting scientific evidence regarding potential chemopreventive effects. Moreover, reveals structure action mechanisms that these are involved in. The review vegetables rich such as carrots green leafy vegetables, well some pineapple, citrus fruits, papaya, mango, Cape gooseberry, have antioxidant, anti-inflammatory, properties can promote a healthy colonic environment. Fruits daily diet antitumor regulating cell signaling and/or proliferation pathways. plant products recommended reduce risk CRC.

Language: Английский

Citations

26