Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 800 - 800

Published: March 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Language: Английский

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The obesity-breast cancer link: a multidisciplinary perspective

Cancer and Metastasis Reviews, Journal Year: 2022, Volume and Issue: 41(3), P. 607 - 625

Published: June 25, 2022

Abstract Obesity, exceptionally prevalent in the USA, promotes incidence and progression of numerous cancer types including breast cancer. Complex, interacting metabolic immune dysregulation marks development both obesity. Obesity chronic low-grade inflammation, particularly white adipose tissue, which drives dysfunction marked by increased pro-inflammatory cytokine production, alternative macrophage activation, reduced T cell function. Breast tissue is predominantly composed adipose, developing readily directly interacts with cells signals from remodeled This review discusses biological mechanisms through obesity cancer, role health disparities, dietary interventions to mitigate adverse effects on We detail intersection an emphasis shared unique patterns these disease processes. have highlighted key areas biology exacerbated obesity, incidence, progression, therapeutic response. posit that interception obesity-driven will require limit protumor signaling obese consider genetic, structural, social determinants obesity–breast link. Finally, we evidence for various offset clinical preclinical studies In light strong associations between rising rates many parts world, effective, safe, well-tolerated, equitable burden are urgently needed.

Language: Английский

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The Effects of the Mediterranean Diet on Health and Gut Microbiota

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2150 - 2150

Published: April 29, 2023

The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions vegetables, fruit, cereals, olive oil. Although there are challenges with isolating the MD from typical lifestyle culture (including prolonged ‘social’ meals siestas), much evidence supports health benefits that include improved longevity, reduced metabolic risk Diabetes Mellitus, obesity, Metabolic Syndrome, malignancy cardiovascular disease, cognitive function. also associated characteristic modifications to gut microbiota, mediated through its constituent parts (primarily dietary fibres, extra virgin oil, polyunsaturated fatty acids [including ω-3]). These enhanced growth species produce short-chain (butyrate), such as Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides, Faecalibacterium prausnitzii species, Firmicutes Blautia species. Such changes in microbiota known be favourably inflammatory oxidative status, propensity for overall health. A key challenge future explore extent which by microbiota. confers both environmental benefits. Adoption should perhaps encouraged facilitated more generally not just restricted populations regions. However, this approach limited perennial availability some non-Mediterranean regions, intolerability a high-fibre diet people, potential cultural disconnects juxtapose traditional Western) diets MD.

Language: Английский

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Mediterranean Diet and Sarcopenia Features in Apparently Healthy Adults over 65 Years: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1104 - 1104

Published: Feb. 22, 2023

Low muscle mass combined with changes in physical function and quality is defined as sarcopenia. In people > 60 years, sarcopenia reaches 10% tends to increase age. Individual nutrients, such protein, may have a protective role against sarcopenia, but recent evidence suggests that protein alone has been ineffective increasing strength. Dietary patterns, instead, high "anti-inflammatory" potential, the Mediterranean dietary pattern, considered an emerging remedy The aim of this systematic review was summarize diet prevention and/or improvement, including data, healthy elders. We searched published studies about until December 2022 Pubmed, Cochrane, Scopus search engine grey literature. total, ten articles were identified relevant: four cross-sectional six prospective. No clinical trial identified. Only three assessed presence measured mass, which essential criterion diagnosis. adherence had, general, positive function, while results less clear regard Additionally, there no effect on There need for conduction trials order reach cause-effects conclusions regarding importance management non-Mediterranean populations.

Language: Английский

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The Association Between Adherence to the Mediterranean Diet and Depression and Anxiety Symptoms in University Students: The Mediating Role of Lean Mass and the Muscle Strength Index

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 346 - 346

Published: Jan. 18, 2025

Background/objectives: recent studies have suggested that components typical of the Mediterranean diet (MedDiet) are associated with depression and anxiety prevention. In this sense, main objective study was to analyse associations between adherence MedDiet symptoms examine whether relationship is mediated by lean mass muscle strength index (MSI). Methods: a cross-sectional (based on data obtained from Nuts4Brain-Z study) conducted 2023–2024, involving 428 university students, aged 18–30 years, Spanish public university. Depression assessed using Beck Inventory (BDI-II), via General Anxiety Disorder-7 (GAD-7) tool. Adherence MEDAS questionnaire. Lean bioimpedance, MSI measured dynamometer. ANCOVA models were used test mean differences in scores categories (low < 9 points vs high ≥ points). Serial multiple mediation models, adjusted for confounders, explore role relationships symptoms. Results: students exhibited lower (p 0.05) than did low MedDiet. The analysis preliminarily revealed both acted as mediators anxiety. Conclusion:adherence per se does not appear direct effect because these partially (for depression) or entirely anxiety) explained MSI.

Language: Английский

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Strategies for increased adherence to the Mediterranean or healthy diet in university food services: a systematic review

International Journal of Food Sciences and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 9, 2025

The Mediterranean diet (MD) has been recognised as a healthy and sustainable model. Despite this, current eating habits diverge significantly from established dietary recommendations, namely the MD among young university students. of people are characterised by high consumption energy-dense foods low vegetables fruit. Thus, canteen food services essential in promoting diet. This systematic review aimed to identify strategies for adherence diets Higher Education service. was based on Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). Of 39 studies that were retrieved, all focused improve eating, none specifically used term "Mediterranean". Studies conducted different countries worldwide. Architectural nudges, discounts nutritional information identified successful strategies, especially females students with higher nutrition education. A combination nudging service is promising way promote healthier habits.

Language: Английский

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Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations

Endocrine, Journal Year: 2021, Volume and Issue: 74(3), P. 478 - 497

Published: Oct. 8, 2021

Language: Английский

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Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms

Molecules, Journal Year: 2022, Volume and Issue: 27(2), P. 477 - 477

Published: Jan. 12, 2022

Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as healthy dietary pattern with protective effects several chronic diseases, including breast cancer. This characterized by consumption abundant plant foods olive oil principal source fat, which considered one main components potential antioxidant, anti-inflammatory anticancer effects. Extra-virgin (EVOO) bioactive compounds, mainly monounsaturated fatty acids, triterpenes polyphenols, such phenolic alcohols (e.g., hydroxytyrosol), secoiridoids oleuropein oleocanthal), lignans pinoresinol) or flavonoids luteolin). While epidemiological evidence still limited, experimental vivo vitro data have shown effect this its compounds on mammary carcinogenesis. Such account through complex multiple mechanisms, changes epigenetics, transcriptome protein expression that modulate signaling pathways. Molecular targets EVOO role acquisition hallmarks. Although further research needed to elucidate their beneficial human prevention progression disease, points context heathy choice, while may be promising adjuvants strategies.

Language: Английский

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The Role of Diet and Dietary Patterns in Parkinson’s Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4472 - 4472

Published: Oct. 25, 2022

Parkinson’s Disease (PD) is a neurodegenerative disorder associated with diminished nutrition status and decreased quality of life. While the prevalence PD expected to increase, no preventative or curative therapy for exists at this time. Although diet represent modifiable risk factors reducing chronic disease risk, research on impact single nutrients has yielded mixed results. As result, single-nutrient approach may be driving force behind inconsistency, holistic dietary overcome inconsistency by accounting interactions between nutrients. The following review aims examine generally healthy pattern, protein-restricted (PRD), ketogenic (KD), Mediterranean (MD), Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) progression, severity. most included studies support role patterns in alleviating severity, inconsistent results need further evidence necessitate more being conducted before making recommendations. Research potential beneficial effects should also investigate risks.

Language: Английский

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European Head and Neck Society recommendations for head and neck cancer survivorship care

Oral Oncology, Journal Year: 2022, Volume and Issue: 133, P. 106047 - 106047

Published: Aug. 3, 2022

Language: Английский

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