Cited by Cephalometric Examination of Soft Palate, Hyoid and Upper Airway Anatomy in Obstructive Sleep Apnea Syndrome Patients

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome DOI

Renjun Lv, Xueying Liu, Yue Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Abstract Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in which the airways narrow or collapse during sleep, causing obstructive apnea. The prevalence of OSAS continues to rise worldwide, particularly middle-aged and elderly individuals. mechanism upper airway incompletely understood but associated with several factors, including obesity, craniofacial changes, altered muscle function airway, pharyngeal neuropathy, fluid shifts neck. main characteristics are recurrent pauses respiration, lead intermittent hypoxia (IH) hypercapnia, accompanied by blood oxygen desaturation arousal sharply increases risk diseases. This paper first briefly describes epidemiology, incidence, pathophysiological mechanisms OSAS. Next, alterations relevant signaling pathways induced IH systematically reviewed discussed. For example, can induce gut microbiota (GM) dysbiosis, impair intestinal barrier, alter metabolites. These ultimately secondary oxidative stress, systemic inflammation, sympathetic activation. We then summarize effects on disease pathogenesis, cardiocerebrovascular disorders, neurological metabolic diseases, cancer, reproductive COVID-19. Finally, different therapeutic strategies for caused causes proposed. Multidisciplinary approaches shared decision-making necessary successful treatment future, more randomized controlled trials needed further evaluation define what treatments best specific patients.

Language: Английский

Citations

164

OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology DOI

Brian W. Locke,

Janet J. Lee,

Krishna M. Sundar

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(9), P. 5473 - 5473

Published: April 30, 2022

Obstructive sleep apnea (OSA) is a highly prevalent disorder that has profound implications on the outcomes of patients with chronic lung disease. The hallmark OSA collapse oropharynx resulting in transient reduction airflow, large intrathoracic pressure swings, and intermittent hypoxia hypercapnia. subsequent cytokine-mediated inflammatory cascade, coupled tractional injury, damages lungs may worsen several conditions, including obstructive pulmonary disease, asthma, interstitial hypertension. Further complicating this fragmentation deterioration quality occurs because OSA, which can compound fatigue physical exhaustion often experienced by due to their For many disorders, available evidence suggests prompt recognition treatment sleep-disordered breathing improves life also alter course illness. However, more robust studies are needed truly understand relationship impacts confounding comorbidities such as obesity gastroesophageal reflux Clinicians taking care disease should screen treat for given complex bidirectional

Language: Английский

Citations

Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms DOI

Andreas Yiangou, Susan P. Mollan, Alexandra J. Sinclair

et al.

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: 19(12), P. 769 - 785

Published: Nov. 13, 2023

Language: Английский

Citations

The histone demethylase KDM6B links obstructive sleep apnea to idiopathic pulmonary fibrosis DOI

Shuangyu Han, Jie Huang, Chang-qing Yang

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 9, 2025

Abstract Obstructive sleep apnea (OSA) is increasingly recognized for its link to idiopathic pulmonary fibrosis (IPF), though the underlying mechanisms remain poorly understood. Histone lysine demethylase 6B (KDM6B) may either prevent or promote organ fibrosis, but specific role in IPF yet be clarified. This study aimed investigate function and of KDM6B exacerbating effects OSA. We assessed levels lung tissues from patients, mouse models, a dual‐hit model combining OSA‐associated intermittent hypoxia (IH) with bleomycin (BLM) TGF‐β1. evaluated myofibroblast activation, oxidative stress. were elevated patients BLM‐treated mice, as well TGF‐β1‐stimulated myofibroblasts. Importantly, IH significantly worsened BLM‐induced TGF‐β1‐induced further amplifying expression both vivo vitro. Inhibition reduced decreased fibroblast activation migration models. Mechanistically, inhibition led NOX4 plays critical promoting mediating OSA on this condition. Our findings identify novel potential therapeutic target IPF.

Language: Английский

Citations

Digital and AI-Enhanced Cognitive Behavioral Therapy for Insomnia: Neurocognitive Mechanisms and Clinical Outcomes DOI

Evgenia Gkintoni, Stephanos P. Vassilopoulos, Γεώργιος Νικολάου

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2265 - 2265

Published: March 26, 2025

Background/Objectives: This systematic review explores the integration of digital and AI-enhanced cognitive behavioral therapy (CBT) for insomnia, focusing on underlying neurocognitive mechanisms associated clinical outcomes. Insomnia significantly impairs functioning, overall health, quality life. Although traditional CBT has demonstrated efficacy, its scalability ability to deliver individualized care remain limited. Emerging AI-driven interventions-including chatbots, mobile applications, web-based platforms-present innovative avenues delivering more accessible personalized insomnia treatments. Methods: Following PRISMA guidelines, this synthesized findings from 78 studies published between 2004 2024. A search was conducted across PubMed, Scopus, Web Science, PsycINFO. Studies were included based predefined criteria prioritizing randomized controlled trials (RCTs) high-quality empirical research that evaluated AI-augmented interventions targeting sleep disorders, particularly insomnia. Results: The suggest improves parameters, patient adherence, satisfaction, personalization in alignment with individual profiles. Moreover, these technologies address critical limitations conventional CBT, notably those related access scalability. AI-based tools appear especially promising optimizing treatment delivery adapting cognitive-behavioral patterns. Conclusions: While demonstrates strong potential advancing through broader accessibility, several challenges persist. These include uncertainties surrounding long-term practical implementation barriers, ethical considerations. Future large-scale longitudinal is necessary confirm sustained benefits AI-powered

Language: Английский

Citations

Sleep Apnea and Cardiovascular Risk in Patients with Prediabetes and Type 2 Diabetes DOI

Stavroula Α. Paschou, Evanthia Bletsa, Katerina Saltiki

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 4989 - 4989

Published: Nov. 24, 2022

Obstructive sleep apnea (OSA) is a common but largely undiagnosed clinical condition, which turning into serious public health issue. Of note that its prevalence gradually increasing in parallel with the obesity and type 2 diabetes mellitus (T2DM) epidemics. The aim of this article to comprehensively review literature order evaluate cardiovascular (CV) risk among patients OSA prediabetes or T2DM. seems be an independent factor for development as well progression T2DM, whereas it associated T2DM-related macrovascular microvascular complications. may also act potential presentation CV disease, such hypertension, coronary artery heart failure, pulmonary atrial fibrillation other cardiac arrythmias, stroke. T2DM share pathophysiological mechanisms leading atherosclerosis. Considering coexistence cumulative mortality, more so than two diseases separately, clinicians healthcare professionals should aware screen Notably, targeted therapy both conditions substantially improve prognosis.

Language: Английский

Citations

The role of the autonomic nervous system in polycystic ovary syndrome DOI

Yue Yu, Tong Chen, Zheng Zheng

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 19, 2024

This article reviewed the relationship between autonomic nervous system and development of polycystic ovary syndrome (PCOS). PCOS is most common reproductive endocrine disorder among women age. Its primary characteristics include persistent anovulation, hyperandrogenism, ovarian morphology, often accompanied by disturbances in glucose lipid metabolism. The body’s functions are regulated system, which consists mainly sympathetic parasympathetic systems. helps maintain homeostasis body. Research indicates that function mammals under neural control. ovaries receive central information through plexus nerves superior nerves. Neurotransmitters mediate function, with acetylcholine norepinephrine being predominant neurotransmitters. They influence secretion steroids follicular development. In animal experiments, estrogen, androgens, stress-induced rat models have been used to explore system. Results shown activation contributes rat. clinical practice, assessments patients gradually employed. These heart rate variability testing, measurement muscle nerve activity, skin response post-exercise recovery evaluation. exhibit dysfunction, characterized increased activity decreased vagal activity. Abnormal metabolic indicators can also impact Clinical studies various effective methods for managing regulate patients’ during treatment process. suggests improving may be an approach treating PCOS.

Language: Английский

Citations

Effects of Exercise on Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis DOI

Jiale Peng,

Yuling Yuan,

Yuanhui Zhao

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(17), P. 10845 - 10845

Published: Aug. 31, 2022

With exercise being more frequently utilized in treatment for obstructive sleep apnea (OSA), a systematic review of the intervention efficacy on OSA is necessary. PubMed, EBSCO, Web Science, VIP, and CNKI databases were searched to collect randomized controlled trials (RCTs) applied from January 2000 2022. The literature screening, data extraction, risk bias assessment included studies conducted independently by two reviewers. Meta-analysis was then performed using Rev Man 5.4 software. A total 9 RCTs included, including 444 patients. Compared with control group, made an improvement apnea–hypopnea index (AHI) [MD = −6.65, 95% CI (−7.77, −5.53), p < 0.00001], minimum oxygen saturation (SaO2min%) 1.67, (0.82, 2.52), 0.0001], peak uptake (VO2peak) [SMD 0.54, (0.31, 0.78), Pittsburgh quality (PSQI) −2.08, (−3.95, −0.21), 0.03], Epworth Sleepiness Scale (ESS) values −1.64, CI, (−3.07, −0.22), 0.02]. However, there no significant changes body mass (BMI). As results subgroup analysis, aerobic combined resistance −7.36, (−8.64, −6.08), 0.00001] had better effect AHI reduction than alone −4.36, (−6.67, −2.06), 0.0002]. This demonstrates that reduces severity BMI, training reduction. Exercise also improves cardiopulmonary fitness, quality, excessive daytime sleepiness.

Language: Английский

Citations

Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences DOI

Mikołaj Malicki,

Filip Franciszek Karuga, Bartosz Szmyd

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 13(1), P. 60 - 60

Published: Dec. 30, 2022

Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of and hypopnea during sleep. It associated with various cardiovascular metabolic complications, including type 2 diabetes mellitus (T2DM) obesity. Many pathways can be responsible for T2DM development in OSA patients, e.g., those related to HIF-1 SIRT1 expression. Moreover, epigenetic mechanisms, such as miRNA181a or miRNA199, are postulated play pivotal role this link. has been proven that increases the occurrence circadian clock disruption, which also risk factor disease development. Circadian disruption impairs metabolism glucose, lipids, secretion bile acids. Therefore, OSA-induced may potential, complex, underlying pathway involved developing exacerbating diseases among patients. The current paper summarizes available information pertaining relationship between context potential mechanisms leading disorders.

Language: Английский

Citations

Real-Time Detection of Sleep Apnea Based on Breathing Sounds and Prediction Reinforcement Using Home Noises: Algorithm Development and Validation DOI

Vu Linh Le, Daewoo Kim, Eunsung Cho

et al.

Journal of Medical Internet Research, Journal Year: 2023, Volume and Issue: 25, P. e44818 - e44818

Published: Feb. 22, 2023

Multinight monitoring can be helpful for the diagnosis and management of obstructive sleep apnea (OSA). For this purpose, it is necessary to able detect OSA in real time a noisy home environment. Sound-based assessment holds great potential since integrated with smartphones provide full noncontact at home.The purpose study develop predictive model that time, even environment where various noises exist.This included 1018 polysomnography (PSG) audio data sets, 297 smartphone sets synced PSG, noise set containing 22,500 train predict breathing events, such as apneas hypopneas, based on sounds occur during sleep. The whole sound each night was divided into 30-second epochs labeled "apnea," "hypopnea," or "no-event," were used make robust performance prediction assessed using epoch-by-epoch accuracy severity classification apnea-hypopnea index (AHI).Epoch-by-epoch event detection showed an 86% macro F1-score 0.75 3-class task. had 92% 84% 51% "hypopnea." Most misclassifications made 15% 34% "hypopnea" being wrongly predicted "apnea" respectively. sensitivity specificity (AHI≥15) 0.85 0.84, respectively.Our presents real-time detector works variety environments. Based this, additional research needed verify usefulness multinight diagnostic technologies

Language: Английский

Citations