Neurological post‐acute sequelae of SARS‐CoV‐2 infection DOI Creative Commons
Masaki Takao, Masayuki Ohira

Psychiatry and Clinical Neurosciences, Journal Year: 2022, Volume and Issue: 77(2), P. 72 - 83

Published: Sept. 23, 2022

The novel coronavirus disease 19 (COVID‐19), caused by severe acute respiratory syndrome 2 (SARS‐CoV‐2), can have two phases: (generally 4 weeks after onset) and chronic (>4 onset). Both phases include a wide variety of signs symptoms including neurological psychiatric symptoms. that are considered sequelae COVID‐19 termed post‐COVID condition, long COVID‐19, post‐acute SARS‐CoV‐2 infection (PASC). PASC fatigue, dyspnea, palpitation, dysosmia, subfever, hypertension, alopecia, sleep problems, loss concentration, amnesia, numbness, pain, gastrointestinal symptoms, depression, anxiety. Because the specific pathophysiology has not yet been clarified, there no definite criteria hence World Health Organization's definition is quite broad. Consequently, it difficult to correctly diagnose PASC. Approximately 50% patients may show at least one symptom up 12 months infection; however, exact prevalence determined. Despite extensive research in progress worldwide, currently clear diagnostic methodologies or treatments for In this review, we discuss available information on highlight infection. Furthermore, provide clinical suggestions diagnosing caring with based our outpatient clinic experience.

Language: Английский

Dysautonomia in COVID-19 Patients: A Narrative Review on Clinical Course, Diagnostic and Therapeutic Strategies DOI Creative Commons
Francisco Carmona-Torre, Ane Mínguez‐Olaondo, A. López-Bravo

et al.

Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 13

Published: May 27, 2022

Introduction On March 11, 2020, the World Health Organization sounded COVID-19 pandemic alarm. While efforts in first few months focused on reducing mortality of infected patients, there is increasing data effects long-term infection (Post-COVID-19 condition). Among different symptoms described after acute infection, those derived from autonomic dysfunction are especially frequent and limiting. Objective To conduct a narrative review synthesizing current evidence signs dysautonomia patients diagnosed with COVID-19, together compilation available treatment guidelines. Results Autonomic associated SARS-CoV-2 occurs at temporal stages. Some proposed pathophysiological mechanisms include direct tissue damage, immune dysregulation, hormonal disturbances, elevated cytokine levels, persistent low-grade infection. Acute has impact risk, given its repercussions respiratory, cardiovascular, neurological systems. Iatrogenic side effect caused by drugs used and/or admission to intensive care unit. Finally, late 2.5% Post-COVID-19 condition. orthostatic hypotension neurally-mediated syncope should be considered, postural tachycardia syndrome (POTS) appears most common phenotype among these patients. A diagnostic guidelines each type dysautonomic condition was done. Conclusion Symptoms deriving involvement affected COVID-19. These have great quality life both short medium long term. better understanding Post-COVID manifestations that affect nervous system, targeted therapeutic management could help reduce sequelae if we act earliest phases disease.

Language: Английский

Citations

56
Investigating the possible mechanisms of autonomic dysfunction post-COVID-19 DOI Open Access

Maya Jammoul,

Judith Naddour,

Amir Madi

et al.

Autonomic Neuroscience, Journal Year: 2022, Volume and Issue: 245, P. 103071 - 103071

Published: Dec. 24, 2022

Language: Английский

Citations

52
Risk Factors and Multidimensional Assessment of Long Coronavirus Disease Fatigue: A Nested Case-Control Study DOI
Ili Margalit, Dana Yelin,

Moshe Sagi

et al.

Clinical Infectious Diseases, Journal Year: 2022, Volume and Issue: 75(10), P. 1688 - 1697

Published: April 11, 2022

Abstract Background Fatigue is the most prevalent and debilitating long-COVID (coronavirus disease) symptom; however, risk factors pathophysiology of this condition remain unknown. We assessed for fatigue explored its possible pathophysiology. Methods This was a nested case-control study in COVID recovery clinic. Individuals with (cases) without (controls) significant were included. performed multidimensional assessment evaluating various parameters, including pulmonary function tests cardiopulmonary exercise testing, implemented multivariable logistic regression to assess fatigue. Results A total 141 individuals The mean age 47 (SD: 13) years; 115 (82%) recovering from mild coronavirus disease 2019 (COVID-19). Mean time evaluation 8 months following COVID-19. Sixty-six (47%) classified They had significantly higher number children, lower proportion hypothyroidism, sore throat during acute illness, proportions symptoms, physical limitation daily activities. also poorer sleep quality degree depression. heart rate [153.52 (22.64) vs 163.52 (18.53); P = .038] oxygen consumption per kilogram [27.69 (7.52) 30.71 (7.52); .036] at peak exercise. 2 independent identified analysis (OR: .79 10 beats/minute; 95% CI: .65–.96; .019) memory impairment 3.76; 1.57–9.01; .003). Conclusions Long-COVID may be related autonomic dysfunction, impaired cognition, decreased mood. suggest limbic-vagal Clinical Trials Registration NCT04851561.

Language: Английский

Citations

48
Prevalence and patterns of symptoms of dysautonomia in patients with long‐COVID syndrome: A cross‐sectional study DOI
Ahmed El‐Dokla, Samar Farag Mohamed,

Ahmed Fouad

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2022, Volume and Issue: 9(6), P. 778 - 785

Published: April 8, 2022

The association between autonomic dysfunction and long-COVID syndrome is established. However, the prevalence patterns of symptoms dysautonomia in a large population are lacking.To evaluate patients with syndrome.We administered Composite Autonomic Symptom Score 31 (COMPASS-31) questionnaire to sample post-COVID-19 who were referred post-COVID clinic Assiut University Hospitals, Egypt for concerning syndrome. Participants asked complete COMPASS-31 referring period more than 4 weeks after acute COVID-19.We included 320 (35.92 ± 11.92 years, 73% females). median score was 26.29 (0-76.73). most affected domains gastrointestinal, secretomotor, orthostatic intolerance 91.6%, 76.4%, 73.6%, respectively. There positive correlation duration (p < 0.001) domain 0.001). age participants = 0.004). Two hundred forty-seven (76.7%) had high >16.4. Patients >16.4 longer those <16.4 (46.2 vs. 26.8 weeks, p 0.001).Symptoms common intolerance. patients' age.

Language: Английский

Citations

40
Local anesthetics as a therapeutic tool for post COVID-19 patients: A case report DOI Creative Commons
David Vinyes, Montserrat Muñoz-Sellart,

Teresa García Caballero

et al.

Medicine, Journal Year: 2022, Volume and Issue: 101(28), P. e29358 - e29358

Published: July 15, 2022

Background: Post COVID-19 syndrome (PC-19S) appears to be independent of acute illness severity and humoral response. The involvement the autonomic nervous system (ANS), expressed by dysautonomia, has been hypothesized as a contributor. Several studies have associated therapeutic effects local anesthetics (LA) their action on ANS. To best our knowledge, this is first report injections with LA linked clinical improvement in patient PC-19S. Patient concerns diagnoses: This was 54-year-old-man postCOVID-19 symptoms lasting 14 weeks, including fatigue, breathlessness, diarrhea, muscle pain, emotional lability. Interventions outcome: Injections 0.5% procaine stellate ganglion (SG) sphenopalatine (SPG), clinically relevant points scalp, thorax, abdomen were performed 3 times over months. reported progressive asymptomatic upon completing treatment. Prescribed medications discontinued. 36-Item Short Form Health Survey (SF-36) score showed significant across all SF-36-domains. Conclusion: Subanesthetic doses injected led rapid complete symptom resolution Targeted may benefits PC-19S other chronic diseases stress inflammation.

Language: Английский

Citations

40
Long-COVID Syndrome and the Cardiovascular System: A Review of Neurocardiologic Effects on Multiple Systems DOI Open Access

Nicholas L. DePace,

Joe Colombo

Current Cardiology Reports, Journal Year: 2022, Volume and Issue: 24(11), P. 1711 - 1726

Published: Sept. 30, 2022

Language: Английский

Citations

40
High Incidence of Autonomic Dysfunction and Postural Orthostatic Tachycardia Syndrome in Patients with Long COVID: Implications for Management and Health Care Planning DOI Open Access
Marie‐Claire Seeley, Celine Gallagher,

Eric Ong

et al.

The American Journal of Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Language: Английский

Citations

38
Deficient GABABergic and glutamatergic excitability in the motor cortex of patients with long-COVID and cognitive impairment DOI Open Access
Paolo Manganotti,

Marco Michelutti,

Giovanni Furlanis

et al.

Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 151, P. 83 - 91

Published: May 10, 2023

Language: Английский

Citations

29
Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers DOI Creative Commons

Karina Carvalho Marques,

Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Language: Английский

Citations

29
Autoimmunity in Long Covid and POTS DOI Creative Commons

Fatema-Zahra El-Rhermoul,

Artur Fedorowski,

Philip Eardley

et al.

Oxford Open Immunology, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 1, 2023

Abstract Orthostatic intolerance and other autonomic dysfunction syndromes are emerging as distinct symptom clusters in Long Covid. Often accompanying these common, multi-system constitutional features such fatigue, malaise skin rashes which can signify generalized immune dysregulation. At the same time, multiple autoantibodies identified both Covid-related disorders non-Covid disorders, implying a possible underlying autoimmune pathology. The lack of specificity findings precludes direct interpretations cause association, but their prevalence with its supporting evidence is compelling.

Language: Английский

Citations

28