ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

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Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(10), P. e2236057 - e2236057

Published: Oct. 12, 2022

Importance Reduced exercise capacity is commonly reported among individuals with COVID-19 symptoms more than 3 months after SARS-CoV-2 infection (long [LC]). Cardiopulmonary testing (CPET) the criterion standard to measure and identify patterns of exertional intolerance. Objectives To estimate difference in without LC characterize physiological limitations elucidate possible mechanisms LC. Data Sources A search PubMed, EMBASE, Web Science, preprint servers, conference abstracts, cited references was performed on December 20, 2021, again May 24, 2022. medrxiv.org, biorxiv.org, researchsquare.com June 9, Study Selection Studies adults earlier that included CPET-measured peak oxygen consumption (V̇ o 2 ) were screened independently by blinded reviewers; 72 (2%) selected for full-text review, 35 (1%) met inclusion criteria. An additional studies identified from servers. Extraction Synthesis extraction independent reviewers according PRISMA reporting guideline. pooled using random-effects models. Main Outcomes Measures Difference V̇ (in mL/kg/min) persistent infection. Results total 38 CPET 2160 18 infection, including 1228 consistent Most case series or cross-sectional assessments within posthospitalization cohorts. Based a meta-analysis 9 464 359 symptoms, mean −4.9 (95% CI, −6.4 −3.4) mL/kg/min those low degree certainty. Deconditioning peripheral (abnormal extraction) common, but dysfunctional breathing chronotropic incompetence also described. The existing literature limited small sample sizes, selection bias, confounding, varying symptom definitions interpretations, resulting high risk bias heterogeneity. Conclusions Relevance findings this systematic review study suggest reduced compared confidence. Potential intolerance other deconditioning include altered autonomic function (eg, incompetence, breathing), endothelial dysfunction, muscular mitochondrial pathology.

Language: Английский

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Post-COVID-19 fatigue: A systematic review

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 11, 2022

Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. This systematic review was performed to describe symptoms, etiology, possible risk factors related post-COVID-19 fatigue and therapeutic approaches used for treatment fatigue. For literature search databases PubMed, Web Science, Cochrane Library, PsycInfo were used. All articles that met inclusion criteria analyzed demographics, clinical data treatment. Included studies which focused on an adult population (18-65 years old); elderly patients chronic somatic diseases can also cause excluded. We identified 2,851, screened 2,193 finally included 20 moderate high methodological quality, encompassing 5,629 participants. Potential old age, female sex, severe status acute phase infection, a number comorbidities, prediagnosis depression/anxiety. Lastly, autoimmune etiology suspected. Several have been tested mostly small uncontrolled so far: Chinese herbal formulation improved breathlessness Moreover, molecular hydrogen (H

Language: Английский

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Factors Associated With Long COVID Symptoms in an Online Cohort Study

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 10(2)

Published: Feb. 1, 2023

Few prospective studies of Long COVID risk factors have been conducted. The purpose this study was to determine whether sociodemographic factors, lifestyle, or medical history preceding COVID-19 characteristics acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are associated with COVID.In March 26, 2020, the Citizen Science study, an online cohort began enrolling participants longitudinal assessment symptoms before, during, and after SARS-CoV-2 infection. Adult who reported a positive test result before April 4, 2022 were surveyed for symptoms. primary outcome at least 1 prevalent symptom greater than month Exposures interest included age, sex, race/ethnicity, education, employment, socioeconomic status/financial insecurity, self-reported history, vaccination status, variant wave, number symptoms, pre-COVID depression, anxiety, alcohol drug use, sleep, exercise.Of 13 305 test, 1480 (11.1%) responded. Respondents' mean age 53 1017 (69%) female. Four hundred seventy-six (32.2%) median 360 days In multivariable models, (odds ratio [OR], 1.30 per symptom; 95% confidence interval [CI], 1.20-1.40), lower insecurity (OR, 1.62; CI, 1.02-2.63), preinfection depression 1.08; 1.01-1.16), earlier variants (OR = 0.37 Omicron compared ancestral strain; 0.15-0.90) symptoms.Variant severity infection, pre-existing

Language: Английский

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Mechanisms of long COVID and the path toward therapeutics

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies

Archives of Microbiology & Immunology, Journal Year: 2023, Volume and Issue: 07(02)

Published: Jan. 1, 2023

Long Covid is one of the most prevalent and puzzling conditions that arose with pandemic. Covid-19 infection generally resolves within several weeks but some experience new or lingering symptoms. Though there no formal definition for such symptoms CDC boadly describes long as persons having a wide range new, recurring sustained health issues four more after first being infected SARS-CoV2. The WHO defines manifestation from "probable confirmed" start approximately 3 months onset acute last than 2 months. Numerous studies have looked at implications on various organs. Many specific mechanisms been proposed changes. In this article, we provide an overview main by which induces end-organ damage in recent research studies. We also review treatment options, current clinical trials, other potential therapeutic avenues to control followed information about effect vaccination Covid. Lastly, discuss questions knowledge gaps present understanding believe effects has quality life, future life expectancy are required better understand eventually prevent treat disease. acknowledge not limited those article it may affect offspring therefore, deem important identify prognostic targets condition.

Language: Английский

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Risk factors associated with post-acute sequelae of SARS-CoV-2: an N3C and NIH RECOVER study

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 25, 2023

Abstract Background More than one-third of individuals experience post-acute sequelae SARS-CoV-2 infection (PASC, which includes long-COVID). The objective is to identify risk factors associated with PASC/long-COVID diagnosis. Methods This was a retrospective case–control study including 31 health systems in the United States from National COVID Cohort Collaborative (N3C). 8,325 PASC (defined by presence International Classification Diseases, version 10 code U09.9 or long-COVID clinic visit) matched 41,625 controls within same system and index date ± 45 days corresponding case's earliest date. Measurements included demographics, comorbidities, treatment acute characteristics related COVID-19. Multivariable logistic regression, random forest, XGBoost were used determine associations between PASC. Results Among PASC, majority > 50 years age (56.6%), female (62.8%), non-Hispanic White (68.6%). In middle-age categories (40 69 years; OR ranging 2.32 2.58), sex (OR 1.4, 95% CI 1.33–1.48), hospitalization COVID-19 3.8, 3.05–4.73), long (8–30 days, 1.69, 1.31–2.17) extended hospital stay (30 + 3.38, 2.45–4.67), receipt mechanical ventilation 1.44, 1.18–1.74), several comorbidities depression 1.50, 1.40–1.60), chronic lung disease 1.63, 1.53–1.74), obesity 1.23, 1.16–1.3) increased likelihood diagnosis care at clinic. Characteristics lower younger (18 29 years), male sex, Black race, such as substance abuse, cardiomyopathy, psychosis, dementia. doctors per capita county residence an Our findings consistent sensitivity analyses using variety analytic techniques approaches select controls. Conclusions national identified important for middle age, severe disease, specific comorbidities. Further clinical epidemiological research needed better understand underlying mechanisms potential role vaccines therapeutics altering course.

Language: Английский

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Five cluster classifications of long COVID and their background factors: A cross-sectional study in Japan

Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(7), P. 3663 - 3670

Published: April 7, 2023

Language: Английский

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Global prevalence of post-COVID-19 sleep disturbances in adults at different follow-up time points: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2023, Volume and Issue: 71, P. 101833 - 101833

Published: Aug. 11, 2023

Language: Английский

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Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019

The Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 228(5), P. 542 - 554

Published: May 11, 2023

Abstract Background Mechanisms underlying persistent cardiopulmonary symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (postacute sequelae of disease 2019 [COVID-19; PASC] or “long COVID”) remain unclear. This study sought to elucidate mechanisms and reduced exercise capacity. Methods We conducted testing (CPET), cardiac magnetic resonance imaging (CMR) ambulatory rhythm monitoring among adults >1 year SARS-CoV-2 infection, compared those with without symptoms, correlated findings previously measured biomarkers. Results Sixty participants (median age, 53 years; 42% female; 87% nonhospitalized; median 17.6 months infection) were studied. At CPET, 18/37 (49%) had capacity (<85% predicted), 3/19 (16%) (P = .02). The adjusted peak oxygen consumption (VO2) was 5.2 mL/kg/min lower (95% confidence interval, 2.1–8.3; P .001) 16.9% percent predicted (4.3%-29.6%; .02) symptoms. Chronotropic incompetence common. Inflammatory markers antibody levels early in PASC negatively VO2. Late-gadolinium enhancement on CMR arrhythmias absent. Conclusions Cardiopulmonary COVID-19 associated capacity, which earlier inflammatory markers. may explain intolerance some COVID.”

Language: Английский

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