“It changes everything”: Understanding how people experience the impact of living with a lower-grade glioma

Neuro-Oncology Practice, Journal Year: 2024, Volume and Issue: 11(3), P. 255 - 265

Published: Jan. 29, 2024

Quantitative studies show people living with a lower-grade glioma (LGG) often report low health-related quality of life. However, it is unclear how this impact experienced; resulting supportive care needs are also poorly understood. We explored experience the long-term an LGG, to help identify potential needs. conducted semi-structured interviews diverse group LGG (n = 28) across United Kingdom, who had completed primary treatment (male n 16, female 12, mean age 54.6 years, time since diagnosis 8.7 years). Interviews were transcribed and inductive thematic analysis was conducted. Four themes relating experiences generated: "Emotional response diagnosis," "Living 'What ifs'," "Changing relationships," "Faltering independence." These reflect participants' symptoms (eg, fatigue, seizures) impairments motor dysfunction, cognitive deficits), these, in turn, drive impacts on daily (including work, relationships, social activities, transport). Participants spoke about their profound emotion throughout. People can wide-ranging everyday may have extensive This study highlights experienced what means LGG. Best practice suggestions for conducting comprehensive assessments tailored those development personalized plans meet needs, would be critical step ensure that best supported condition.

Language: Английский

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Awake Craniotomy in Africa: A Scoping Review of Literature and Proposed Solutions to Tackle Challenges

Neurosurgery, Journal Year: 2023, Volume and Issue: 93(2), P. 274 - 291

Published: March 24, 2023

BACKGROUND: Awake craniotomy (AC) is a common neurosurgical procedure for the resection of lesions in eloquent brain areas, which has advantage avoiding general anesthesia to reduce associated complications and costs. A significant resource limitation low- middle-income countries constrains usage AC. OBJECTIVE: To review published literature on AC African countries, identify challenges, propose pragmatic solutions by practicing neurosurgeons Africa. METHODS: We conducted scoping under Preferred Reporting Items Systematic Reviews Meta-Analysis-Scoping Review guidelines across 3 databases (PubMed, Scopus, Web Science). English articles investigating Africa were included. RESULTS: Nineteen studies consisting 396 patients Egypt was most represented country with 8 (42.1%), followed Nigeria 6 records (31.6%). Glioma lesion type, corresponding 120 (30.3%), epilepsy 71 (17.9%). Awake-awake-awake protocol used 7 (36.8%). Sixteen (84.2%) contained adult patients. The youngest reported patient 11 years old, whereas oldest one 92. Nine (47.4%) infrastructure limitations performing AC, including lack funding, intraoperative monitoring equipment, imaging, medications, limited human resources. CONCLUSION: Despite many constraints, being safely performed low-resource settings. International collaborations among centers are move forward, but adequate resources management essential make an accessible more centers.

Language: Английский

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High costs, low quality of life, reduced survival, and room for improving treatment: an analysis of burden and unmet needs in glioma

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 20, 2024

Gliomas are a group of heterogeneous tumors that account for substantial morbidity, mortality, and costs to patients healthcare systems globally. Survival varies considerably by grade, histology, biomarkers, genetic alterations such as IDH mutations MGMT promoter methylation, treatment, but is poor some grades histologies, with many glioblastoma surviving less than year from diagnosis. The present review provides an introduction glioma, including its classification, epidemiology, economic humanistic burden, well treatment options. Another focus on recommendations IDH-mutant astrocytoma, oligodendroglioma, glioblastoma, which were synthesized recent guidelines. While nuanced reflect the complexity disease, maximum safe resection typically first step in followed radiotherapy and/or chemotherapy using temozolomide or procarbazine, lomustine, vincristine. Immunotherapies targeted therapies currently have only limited role due disappointing clinical trial results, recurrent nitrosourea lomustine remains de facto standard care. lack options compounded frequently suboptimal practice, do not receive adequate therapy after resection, delayed, shortened, discontinued courses side effects. These unmet needs will require significant efforts address, continued search novel options, increased awareness guidelines, improved toxicity management chemotherapy, generation additional more robust health evidence.

Language: Английский

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Predictive factors for return to work among cancer survivors in Europe: A systematic review

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 200, P. 104422 - 104422

Published: June 17, 2024

Language: Английский

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The urgent need to redefine quality of life in patients with low-grade glioma

ESMO rare cancers., Journal Year: 2025, Volume and Issue: unknown, P. 100003 - 100003

Published: Feb. 1, 2025

Language: Английский

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Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013–2023)

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(4)

Published: March 18, 2025

Advances in medical care have made cancer rehabilitation an essential component of comprehensive treatment. However, bibliometric analyses this field remain limited. This study maps the global research landscape over past decade. Relevant publications on from 2013 to 2023 were retrieved Web Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using VOSviewer, CiteSpace, and R package "Bibliometrics." A total 6743 98 countries demonstrated sustained growth, peaking 2022. The USA (1581 publications) China (974) led output, while Netherlands recorded highest citation impact (32.75 citations per paper). Key institutions included University Texas MD Anderson Cancer Center (148 Memorial Sloan Kettering (40.58 Supportive Care ranked as most influential journal. Research efforts primarily focused exercise interventions (n = 404), quality life 688), breast 440). Recent trends highlighted telemedicine, digital health, cancer-related lymphedema. highlights dominance high-income identifies exercise, life, enduring focal points. Emerging priorities include technology-driven lymphedema management. critical gaps remain, such underrepresentation low-resource regions, limited focus pediatric populations, insufficient integration advanced technologies (e.g., AI, wearables). Future should emphasize equitable resource distribution, evidence-based models, scalable solutions address disparities improve survivorship care.

Language: Английский

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Quality and efficiency of a semi-automatic anatomy-based method for tractography of associative white matter fascicles in brain tumor patients, a case series

Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)

Published: March 26, 2025

Language: Английский

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Resection Location and Work Resumption in Patients With Lower-Grade Glioma: A Multicenter Cohort Study

Neurosurgery Open, Journal Year: 2025, Volume and Issue: 6(2)

Published: April 1, 2025

BACKGROUND AND OBJECTIVES: Patients with newly diagnosed lower-grade glioma (World Health Organization grade II and III) are typically of working age. However, work resumption after surgical resection is uncertain, possibly due to loss capacity from tumor-infiltrated brain regions. Therefore, we explore the association between location in addition other patient, tumor, treatment characteristics. METHODS: This retrospective cohort consisted adults undergoing first-time for 2011 2020 hospitals France, Germany, Netherlands. Employment was evaluated at baseline within 1 year surgery determine resumption. The characteristics analyzed using logistic regression. Resection cavities were segmented postoperative MRI scans, registered standard space related gray nuclei, cortical networks, white matter tracts atlas parcellations. To identify regions potentially involved resumption, Bayesian hurdle identified jointly their multiple RESULTS: Of 207 patients, 181 (87%) employed baseline. these 111 (61%) had resumed follow-up. Male sex, younger age, larger extent independent significant predictors not associated CONCLUSION: Almost two-thirds patients surgery. Work patient (male sex age) resection, but location.

Language: Английский

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Beyond Avoiding Hemiplegia after Glioma Surgery: The Need to Map Complex Movement in Awake Patient to Preserve Conation

Cancers, Journal Year: 2023, Volume and Issue: 15(5), P. 1528 - 1528

Published: Feb. 28, 2023

Improving the onco-functional balance has always been a challenge in glioma surgery, especially regarding motor function. Given importance of conation (i.e., willingness which leads to action) patient’s quality life, we propose here review evolution its intraoperative assessment through reminder increasing knowledge neural foundations—based upon meta-networking organization at three levels. Historical preservation primary cortex and pyramidal pathway (first level), was mostly dedicated avoid hemiplegia, nonetheless shown limits prevent occurrence long-term deficits complex movement. Then, movement control network (second level) permitted such more subtle (but possibly disabling) thanks mapping with direct electrostimulations awake conditions. Finally, integrating multitasking evaluation during surgery (third enabled preserve volition highest finest level according patients’ specific demands (e.g., play instrument or perform sports). Understanding these levels underlying cortico-subcortical basis is therefore critical an individualized surgical strategy centered on choice: this implies increasingly use cognitive monitoring regardless involved hemisphere. Moreover, also pleads for finer systematic before, after as well stronger integration fundamental neurosciences into clinical practice.

Language: Английский

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Brain Plasticity Profiling as a Key Support to Therapeutic Decision-Making in Low-Grade Glioma Oncological Strategies

Cancers, Journal Year: 2023, Volume and Issue: 15(14), P. 3698 - 3698

Published: July 20, 2023

The ability of neural circuits to compensate for damage the central nervous system is called postlesional plasticity. In diffuse low-grade gliomas (LGGs), a crosstalk between brain and tumor activates modulations plasticity, as well proliferation migration, by means paracrine electrical intercommunications. Such adaptative mechanisms have major impact on benefits risks oncological treatments but are still disregarded current neuro-oncological guidelines. this review, authors first aimed highlight clinical, radiological, markers that robustly reflect plasticity potentials limitations in LGG patients, including location degree critical white matter tract infiltration, velocity expansion, reactional changes neuropsychological performances over time. Second, interactions potential/limitations cerebral efficacy/tolerance treatment options (i.e., surgery, chemotherapy, radiotherapy) reviewed. Finally, longitudinal multimodal approach accounting evolutive profiles proposed. an integrates personalized predictive models with step-by-step therapeutic decision making supports onco-functional balanced strategies patients LGG, ultimate aim optimizing overall survival quality life.

Language: Английский

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