Multicentre retrospective detection of nailfold videocapillaroscopy abnormalities in long covid patients

RMD Open, Journal Year: 2025, Volume and Issue: 11(2), P. e005469 - e005469

Published: April 1, 2025

Background SARS-CoV-2 induces acute non-specific endothelial/microvascular alterations that have been identified by nailfold videocapillaroscopy (NVC). Details on NVC abnormalities in long covid (LC) patients (pts) are unknown. Methods LC pts without and with systemic sclerosis (non-SSc-LC SSc-LC), recovered COVID-19 (RC) did not develop healthy matched control subjects (CNT) underwent examinations were evaluated a multicentre national study from the Capillaroscopy Microcirculation Rheumatic Diseases Study Group of Italian Society Rheumatology. Retrospective collection was performed for demographic data, course infection, comorbidities, concomitant drugs. quantified validated scores. Pre-COVID-19 post-COVID-19 microvascular status analysed NVC. Results 62 non-SSc-LC (49 female/13 male, 51±16 years old), 24 SSc-LC (21 female/3 59±17 23 RC (18 female/5 51±18 old) 84 CNT (68 female/16 52±12 analysed. Non-SSc-LC showed significantly more dilated capillaries (p<0.01, p multivariate<0.01), microhaemorrhages (p=0.01, multivariate<0.05), abnormal shapes (p<0.05, multivariate<0.05) than note, lower mean capillary number per linear millimetre multivariate<0.01) both CTN multivariate<0.05). Of highest interest, 16 statistically (p<0.05) after COVID-19, compared pre-COVID-19 status. Similarly, (24) density (p=0.01) (p<0.01) Conclusions show at as CNT, which may contribute to pathogenesis persistent organ/systems dysfunction.

Language: Английский

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Evaluation of blood pressure variation in recovered COVID-19 patients at one-year follow-up: a retrospective cohort study

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 7, 2024

Abstract Background Coronavirus disease 2019 (COVID-19) has various sequelae, one of which might be hypertension. We aimed to evaluate COVID-19’s impact on blood pressure (BP) in non-hospitalized patients at one-year follow-up. Method A total 7,950 consecutive COVID-19 regularly visiting our cardiology clinic were retrospectively screened. Patients’ electronic medical records including demographics, comorbidities, vital signs, treatments, and outcomes, reviewed by two physicians. Individuals with least BP measurement the three months preceding 12 or more following recovery included. levels before after compared using paired t-test. Results 5,355 confirmed (mean age 55.51 ± 15.38 years) Hypertension (56.9%) diabetes mellitus (34%) predominant 44.3% had prior major adverse cardiovascular events. Both systolic (126.90 20.91 vs. 139.99 23.94 mmHg, P < 0.001) diastolic (80.54 13.94 86.49 14.40 significantly higher post-COVID-19 pre-COVID-19. Notably, 456 (14%) hypertensive experienced exacerbated hypertension, while 408 (17%) developed new-onset overall 864 (16%) exacerbation new Linear regression analysis revealed that advanced age, smoking, previous events, predict increased ( 0.001). Conclusion raised long term patients, over one-sixth developing All should evaluated regarding BP, recovery, particularly those mentioned predictive factors. (clinicaltrial.gov: NCT05798208)

Language: Английский

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A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1168 - 1168

Published: May 31, 2024

Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses;

Language: Английский

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Beyond acute infection: mechanisms underlying post‐acute sequelae of COVID‐19 (PASC)

The Medical Journal of Australia, Journal Year: 2024, Volume and Issue: 221(S9)

Published: Nov. 3, 2024

Immune dysregulation is a key aspect of post-acute sequelae coronavirus disease 2019 (PASC), also known as long COVID, with sustained activation immune cells, T cell exhaustion, skewed B profiles, and disrupted communication thereby resulting in autoimmune-related complications. The gut emerging critical link between microbiota, metabolism overall dysfunction, potentially sharing similarities other chronic fatigue conditions PASC. Immunothrombosis neurological signalling dysfunction emphasise the complex interplay system, blood clotting, central nervous system context severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Clear research gaps design PASC studies, especially longitudinal research, stand out significant areas concern.

Language: Английский

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Maximal oxidative capacity during exercise is associated with muscle power output in patients with long coronavirus disease 2019 (COVID-19) syndrome. A moderation analysis

Clinical Nutrition ESPEN, Journal Year: 2023, Volume and Issue: 58, P. 253 - 262

Published: Oct. 14, 2023

Long COVID syndrome (LCS) involves persistent symptoms experienced by many patients after recovering from coronavirus disease 2019 (COVID-19). We aimed to assess skeletal muscle energy metabolism, which is closely related substrate oxidation rates during exercise, in with LCS compared healthy controls. also examined whether power output mediates the relationship between COVID-19 and metabolism.

Language: Английский

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Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 82 studies comprising 58 cytokines/chemokines/growth factors

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 8, 2024

Abstract Background Multiple studies have shown that Long COVID (LC) disease is associated with heightened immune activation, as evidenced by elevated levels of inflammatory mediators. However, there no comprehensive meta-analysis focusing on activation the response system (IRS) and compensatory immunoregulatory (CIRS) along other phenotypes in LC patients. Objectives This designed to explore IRS CIRS profiles patients, individual cytokines, chemokines, growth factors, C-reactive protein (CRP) immune-associated neurotoxicity. Methods To gather relevant for our research, we conducted a thorough search using databases such PubMed, Google Scholar, SciFinder, covering all available literature up December 20th, 2023. Results The current encompassed 82 examined multiple profiles, protein, 58 cytokines/chemokines/growth factors 3836 patients versus 4537 normal controls (NC). showed significant increases IRS/CIRS ratio (standardized mean difference (SMD:0.156, confidence interval (CI): 0.051;0.261), (SMD: 0.345, CI: 0.222;0.468), M1 macrophage 0.421, 0.290;0.551), T helper (Th)1 0.353, 0.189;0.517), Th17 0.492, 0.332;0.651) neurotoxicity 0.327 0.205;0.448). In addition, CRP 19 different cytokines displayed significantly compared NC. Conclusion characterized increased

Language: Английский

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Combining Double-Dose and High-Dose Pulsed Dapsone Combination Therapy for Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome and Co-Infections, Including Bartonella: A Report of 3 Cases and a Literature Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 909 - 909

Published: April 30, 2024

Three patients with relapsing and remitting borreliosis, babesiosis, bartonellosis, despite extended anti-infective therapy, were prescribed double-dose dapsone combination therapy (DDDCT) for 8 weeks, followed by one or several two-week courses of pulsed high-dose (HDDCT). We discuss these patients’ cases to illustrate three important variables required long-term remission. First, diagnosing treating active co-infections, including Babesia Bartonella important. rotations multiple anti-malarial drug combinations herbal therapies, 6-day HDDCT pulses achieve clinical Second, all prior oral, intramuscular (IM), and/or intravenous (IV) antibiotics used chronic Lyme disease (CLD)/post-treatment syndrome (PTLDS), irrespective the length administration, inferior in efficacy short-term biofilm/persister i.e., dapsone, rifampin, methylene blue, pyrazinamide, which improved resistant fatigue, pain, headaches, insomnia, neuropsychiatric symptoms. Lastly, addressing factors on 16-point systemic infectious (MSIDS) model was achieving In conclusion, DDDCT 6–7-day HDDCT, while abnormalities MSIDS map, could represent a novel effective strategy CLD/PTLDS associated co-infections Bartonella.

Language: Английский

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Microvascular Changes during Viral Infections: A Systematic Review of Studies Using Retinal Vessel Diameter Assessments

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1488 - 1488

Published: July 5, 2024

Viral infection frequently affects the cardiovascular system, and vascular disturbances in patients can lead to health complications. One essential component of system that is vulnerable inflammatory effects viral infections microcirculatory system. As a suitable practical non-invasive method assess structure function retinal microcirculation, proxy for fundus imaging be used. We examined impact on vessel diameters performed systematic analysis literature. Our search was carried out PubMed using predefined queries. After methodological filtering process, we were able reduce corpus 363 publications 16 studies met parameters. used narrative review style summarise observations. Six covered COVID-19, seven described HIV, three included subgroup called others, covering viruses, such as Dengue Fever Crimean–Congo Haemorrhagic Fever. Analysis literature showed are associated with alterations vessels’ vasoactivity. COVID-19 other cause inflammation-associated vasodilatation microvasculature short-term effect infection. Long well HIV chronic inflammation impacting microvascular morphology via diameter narrowing. The emphasises importance understudied area infections’ microcirculation. Continuous research this needed further verify an innovative tool optimal diagnosis changes. changes precede bigger arteries, early detection go long way reducing morbidity mortality diseases.

Language: Английский

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Symptom burden, coagulopathy and heart disease after acute SARS-CoV-2 infection in primary practice

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 11, 2024

Language: Английский

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U-Net-based computed tomography quantification of viral pneumonia can predict fibrotic interstitial lung abnormalities at 3-month follow-up

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 30, 2024

Background Given the high prevalence of fibrotic interstitial lung abnormalities (ILAs) post-COVID-19, this study aims to evaluate effectiveness quantitative CT features in predicting ILAs at 3-month follow-up. Methods This retrospective utilized cohorts from distinct clinical settings: training dataset comprised individuals presenting fever clinic and emergency department, while validation included patients hospitalized with COVID-19 pneumonia. They were classified into group nonfibrotic based on whether present A U-Net-based AI tool was used for quantification both pneumonia lesions pulmonary blood volumes. Receiver operating characteristic (ROC) curve analysis multivariate assess their predictive abilities ILAs. Results Among dataset, 122 (mean age 68 years ±16 [standard deviation], 73 men), 55.74% showed The identified volume [PV, odd ratio (OR) 3.28, 95% confidence interval (CI): 1.20–9.31, p = 0.02], consolidation (CV, OR 3.77, CI: 1.37–10.75, 0.01), ground-glass opacity (GV, 3.38, 1.26–9.38, 0.02), mass (PM, 3.58, 1.28–10.46, score (OR 12.06, 3.15–58.89, &lt; 0.001) as independent predictors ILAs, all parameters effective (all &gt; 0.05). And area under (AUC) values PV (0.79), GV (0.78), PM CV (0.80), (0.77). comprising 45 67.29 ± 14.29 years, 25 males) 57.78% showing follow-up, confirmed validity these AUC (0.86), (0.90), (0.83), (0.88), (0.85). Additionally, percentage vessels &lt;5mm 2 relative total (BV5%) significantly lower ( 0.048) compared those without. Conclusion U-Net lesion BV5% baseline scan has potential predict follow-up patients.

Language: Английский

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