Depression and coronary heart disease: mechanisms, interventions, and treatments

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Coronary heart disease (CHD), a cardiovascular condition that poses significant threat to human health and life, has imposed substantial economic burden on the world. However, in contrast conventional risk factors, depression emerges as novel independent factor for CHD. This impacts onset progression of CHD elevates adverse prognostic events those already affected by As result, garnered increasing global attention. Despite this growing awareness, specific mechanisms through which contributes development remain unclear. Existing research suggests primarily influences inflammatory response, Hypothalamic-pituitary-adrenocortical axis (HPA) Autonomic Nervous System (ANS) dysfunction, platelet activation, endothelial lipid metabolism disorders, genetics, all play pivotal roles development. Furthermore, effectiveness safety antidepressant treatment patients with comorbid its potential impact prognosis have become subjects controversy. Further investigation is warranted address these unresolved questions.

Language: Английский

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Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(1), P. 281 - 303

Published: July 8, 2023

Language: Английский

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Traditional Chinese Exercises for Cardiovascular Diseases: A Bibliometric Analysis

Perceptual and Motor Skills, Journal Year: 2024, Volume and Issue: 131(2), P. 514 - 536

Published: Feb. 13, 2024

Traditional Chinese exercises (TCEs) have great value in the prevention and effective treatment of cardiovascular diseases (CVD). Our purpose this study was to summarize present research trends future directions regarding link between TCEs CVD by bibliometrics analysis. We searched Web Science Core Collection (WoSCC) for all original articles reviews on published English before August 7, 2022 using CiteSpace 5.8.R3 Microsoft Excel 2019 software, we displayed results form network maps, line graphs, tables. initially obtained 725 articles. showed that United States most influential country research, with Harvard University prolific institution field, and, Evidence-Based Complementary Alternative Medicine productive journal these The highest-frequency keywords area were Tai Chi, exercise, blood pressure, quality life, older adult. Additionally, important topics included heart rate variability, meta-analysis, Baduanjin breathing exercise. In addition, our revealed among TCEs, Baduanjin, Qigong emerged as extensively studied. However, it’s note exclusive focus literature may led missing results. Future investigators should broaden their search include other databases languages a still more comprehensive overview field.

Language: Английский

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Efficacy of a 4-week yoga module on the sympatho-vagal balance among healthcare workers in a tertiary care hospital: a randomised controlled trial

BMJ Open Sport & Exercise Medicine, Journal Year: 2025, Volume and Issue: 11(1), P. e002448 - e002448

Published: Jan. 1, 2025

Healthcare workers (HCWs) actively involved in patient care at tertiary hospitals face significant stress and workload, which may adversely impact their sympatho-vagal balance (SVB). Research has extensively investigated SVB using various techniques, such as heart rate variability (HRV). With its multifaceted approach, yoga been suggested to influence autonomic nervous system function and, consequently, SVB. Thus, this study aims investigate the efficacy of a 4-week module on among HCWs. This randomised controlled trial will involve 108 HCWs aged 19–60 years. Participants be either (1) intervention group or (2) medium-paced walking control group. The primary outcome is change HRV after 4 weeks intervention. Secondary outcomes comprise immediate state anxiety, selective attention compared pre- post-intervention days 1, 14 28. Intention-to-treat per-protocol analysis performed gain comprehensive understanding effects Multivariate linear model adjust covariates baseline data both groups. Independent t-test compare postdata all between Paired used within protocol registered Clinical Trials Registry – India (CTRI) (CTRI/2024/09/074132).

Language: Английский

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An Integrated Platform Combining Immersive Virtual Reality and Physiological Sensors for Systematic and Individualized Assessment of Stress Response (bWell): Design and Implementation Study

JMIR Formative Research, Journal Year: 2025, Volume and Issue: 9, P. e64492 - e64492

Published: March 4, 2025

Stress is a pervasive issue in modern society, manifesting various forms such as emotional, physical, and work-related stress, each with distinct impacts on individuals society. Traditional stress studies often rely psychological, performance, or social tests; however, recently, immersive virtual reality (VR), which provides sense of presence natural interaction, offers the opportunity to simulate real-world tasks stressors controlled environments. Despite its potential, use VR investigate multifaceted manifestations has not been thoroughly explored. This study aimed explore feasibility using VR-based platform, bWell, elicit responses measure resulting behavioral physiological changes. Specifically, we design exercises based neurocardiac models systematically test cardiac functioning within specific contexts self-regulation (executive functioning, physical efforts, emotional regulation). The development process adhered guidelines for clinical trials complex health interventions, encompassing 3 phases: preparation, development, verification. preparation phase involved comprehensive literature review establish links between heart, brain, leading formulation conceptual model Neurovisceral Integration Model (NVIM) Vagal Tank Theory (VTT). designing targeting integrating sensors photoplethysmography (PPG) electromyography (EMG) capture heart rate variability (HRV) facial expressions. verification phase, conducted small number trials, implement workflow testing feasibility, acceptability, tolerability exercises. In addition, potential capturing measures along subjective ratings dimensions was assessed. Verification demonstrated that were well tolerated, negligible cybersickness high user engagement. different successfully elicited intended demands, responses. presents novel experimental setup allows systematic individualized assessment responses, paving way future research identify features confer resilience help manage effectively. While our highlights role HRV providing valuable insights into will involve multivariate machine learning analyses predict individual sensor data, including EMG ultimately guiding personalized management interventions.

Language: Английский

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The Constrained Disorder Principle: Beyond Biological Allostasis

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 339 - 339

Published: March 25, 2025

The constrained disorder principle (CDP) defines complex biological systems based on inherent variability. Allostasis refers to the physiological processes that help maintain stability in response changing environmental demands. Allostatic load describes cumulative wear and tear body resulting from prolonged exposure stress, it has been suggested mediate relationship between stress disease. This study presents concepts of CDP allostasis while discussing their similarities differences. We reviewed current literature potential benefits introducing controlled doses noise into interventions, which may enhance effectiveness therapies. paper highlights promising role variability provided by a CDP-based second-generation artificial intelligence system improving health outcomes.

Language: Английский

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Evaluation of the Age Dependence of Conventional and Novel Photoplethysmography Parameters

Artery Research, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 25, 2025

Language: Английский

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The Role of Neuroinflammation in the Comorbidity of Psychiatric Disorders and Internal Diseases

Healthcare, Journal Year: 2025, Volume and Issue: 13(7), P. 837 - 837

Published: April 7, 2025

Psychiatric disorders and internal diseases frequently co-occur, posing significant challenges due to overlapping symptoms, shared pathophysiological mechanisms, increased healthcare burdens. Neuroinflammation has emerged as a central mechanism linking these conditions, driven by systemic inflammation, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, autonomic nervous system (ANS) imbalance. This review synthesizes current evidence on the role of neuroinflammation in comorbid conditions such depression, anxiety, cardiovascular disease, diabetes mellitus, emphasizing bidirectional relationships inflammatory pathways. analysis identifies gaps longitudinal studies, biomarker validation, integration multidisciplinary care models. Emerging therapeutic approaches, including IL-6 inhibitors, vagus nerve stimulation, behavioral interventions, show promise but remain underexplored combined applications. Furthermore, disparities research representation limit generalizability findings highlight need for inclusive clinical trials. Addressing through precision medicine, advanced monitoring technologies, equitable strategies could transform management complex comorbidities. By advancing our understanding neuroinflammatory mechanisms promoting integrated this underscores collaborative, patient-centered approach improve outcomes reduce global burden psychiatric disease

Language: Английский

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Trauma Center Trauma Sensitive Yoga Intervention (TCTSY). Improving Conditions for Incarcerated Women in Latin America

Medicine Science and the Law, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Female prisoners in Latin America experience significantly higher rates of mental health issues compared to their male counterparts. The most prevalent include anxiety and stress, which stem from feelings insecurity, perceived failure, long periods detention, the inability care for children. Furthermore, over 50% female have been exposed traumatic events, including physical and/or sexual violence, report more adverse childhood experiences post-traumatic stress disorder (PTSD) than prisoners. Understanding root causes these is essential developing effective interventions. Body awareness, crucial consciousness emotion regulation, often compromised individuals with PTSD, exacerbating symptoms. Positive criminology approaches, such as yoga programs, shown improve inmates' well-being by addressing underlying issues. This commentary introduces Trauma Center Sensitive Yoga (TCTSY) a novel intervention designed explicitly PTSD. Research indicates that TCTSY provides significant physiological psychological benefits, reductions negative emotional states, hostility, overall distress. Despite has not yet implemented South American prisons. Given substantial prison population Chile critical needs, introducing settings presents promising opportunity. Implementing could enhance promote prosocial behavior, urgent need interventions this vulnerable population.

Language: Английский

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Comparative Analysis of Heart Rate (HR) and Heart Rate Variability (HRV) Signals for User Authentication Using a Machine Learning Approach

Advanced sciences and technologies for security applications, Journal Year: 2025, Volume and Issue: unknown, P. 559 - 585

Published: Jan. 1, 2025

Language: Английский

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