Cancer Letters,
Journal Year:
2024,
Volume and Issue:
unknown, P. 217391 - 217391
Published: Dec. 1, 2024
Circadian
rhythm,
regulated
by
a
time
keeping
system
termed
as
the
circadian
clock,
is
important
for
many
biological
processes
in
eukaryotes.
Disordered
rhythm
implicated
different
human
diseases,
including
cardiovascular
disease,
neurologic
metabolic
disorders,
and
cancer.
The
stem
like-cancer
cells
(or
cancer
cells,
CSCs)
are
proposed
to
stand
at
top
of
heterogeneous
hierarchy
solid
tumors,
which
responsible
tumor
initiation,
development,
therapy
resistance
metastasis.
Emerging
evidence
has
shown
that
clock
genes
potentially
regulate
stemness
features
CSCs
several
malignant
systems,
leukemia,
glioblastoma,
breast
cancer,
colorectal
prostate
chronotherapies
targeting
therefore
therapeutic
potentials
treating
malignancies.
In
this
review,
we
have
summarized
our
current
knowledge
gene
regulation
normal
stem/progenitor
cells.
Moreover,
provided
linking
dysregulations
development.
Importantly,
listed
potential
mechanisms
underlying
CSCs.
Finally,
offered
attempts
chronotherapy
Elucidating
molecular
will
provide
us
novel
direction
development
therapeutics
target
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(2), P. 353 - 353
Published: Feb. 11, 2023
The
imbalance
between
reactive
oxygen
species
(ROS)
production
and
clearance
causes
oxidative
stress
ROS,
which
play
a
central
role
in
regulating
cell
tissue
physiology
pathology.
Contingent
upon
concentration,
ROS
influence
cancer
development
contradictory
ways,
either
stimulating
survival
growth
or
causing
death.
Cells
developed
evolutionarily
conserved
programs
to
sense
adapt
redox
the
fluctuations
regulate
as
signaling
molecules
toxic
insults.
transcription
factor
nuclear
erythroid
2-related
2
(NRF2)-KEAP1
system
is
master
regulator
of
cellular
metabolic
homeostasis.
NRF2
has
Janus-like
roles
carcinogenesis
development.
Short-term
activation
suppresses
injury,
inflammation,
initiation.
However,
cells
often
exhibit
constitutive
due
genetic
mutations
oncogenic
signaling,
conferring
advantages
for
cells'
growth.
Emerging
evidence
suggests
that
hyperactivation,
an
adaptive
phenotype
under
stressful
tumor
environments,
regulates
all
hallmarks
cancer.
In
this
review,
we
summarized
source
regulation
sensors
(O2),
reviewed
recent
progress
on
generation
with
focus
new
functions
reach
beyond
what
originally
envisioned,
including
metabolism,
autophagy,
macropinocytosis,
unfolded
protein
response,
proteostasis,
circadian
rhythm,
which,
together
anti-oxidant
drug
detoxification
enzymes,
contributes
development,
metastasis,
anticancer
therapy
resistance.
The
intricate
relationship
between
cancer,
circadian
rhythms,
and
aging
is
increasingly
recognized
as
a
critical
factor
in
understanding
the
mechanisms
underlying
tumorigenesis
cancer
progression.
Aging
well-established
primary
risk
for
while
disruptions
rhythms
are
intricately
associated
with
progression
of
various
tumors.
Moreover,
itself
disrupts
leading
to
physiological
changes
that
may
accelerate
development.
Despite
these
connections,
specific
interplay
processes
their
collective
impact
on
remains
inadequately
explored
literature.
In
this
review,
we
systematically
explore
influence
We
discuss
how
core
genes
tumor
prognosis,
highlighting
shared
hallmarks
such
genomic
instability,
cellular
senescence,
chronic
inflammation.
Furthermore,
examine
aging,
focusing
crosstalk
contributes
tumorigenesis,
proliferation,
apoptosis,
well
metabolism
stability.
By
elucidating
common
pathways
linking
review
provides
new
insights
into
pathophysiology
identifies
potential
therapeutic
strategies.
propose
targeting
regulation
could
pave
way
novel
treatments,
including
chronotherapy
antiaging
interventions,
which
offer
important
benefits
clinical
management
cancer.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
199, P. 107032 - 107032
Published: Dec. 5, 2023
Cancer
is
a
leading
cause
of
death
worldwide.
The
burden
cancer
incidence
and
mortality
increasing
rapidly.
New
approaches
to
prevention
treatment
are
urgently
needed.
Natural
products
reliable
powerful
sources
for
anticancer
drug
discovery.
Baicalin
baicalein,
two
major
flavones
isolated
from
Scutellaria
baicalensis
Georgi,
multi-purpose
traditional
medicinal
plant
in
China,
exhibit
activities
against
multiple
cancers.
Of
note,
these
phytochemicals
extremely
low
toxicity
normal
cells.
Besides
their
cytotoxic
cytostatic
toward
diverse
tumor
cells,
recent
studies
demonstrated
that
baicalin
baicalein
modulate
variety
stromal
cells
extracellular
matrix
(ECM)
the
microenvironment
(TME),
which
essential
tumorigenesis,
progression
metastasis.
In
this
review,
we
summarize
therapeutic
potential
mechanism
action
regulation
microenvironmental
immune
endothelial
fibroblasts,
ECM
reshape
TME
signaling,
inhibition
angiogenesis,
progression,
addition,
discuss
biotransformation
pathways
related
challenges
future
research
directions
improve
bioavailability
clinical
applications.
Recent
advances
warrant
continued
study
as
important
natural
ways
interception
therapy.
Cells,
Journal Year:
2024,
Volume and Issue:
13(15), P. 1246 - 1246
Published: July 24, 2024
The
triadic
interplay
between
sleep,
immunity,
and
cancer
represents
a
growing
area
of
biomedical
research
with
significant
clinical
implications.
This
review
synthesizes
the
current
knowledge
on
how
sleep
influences
immune
function,
system’s
role
in
dynamics,
direct
connections
patterns
risk.
After
comprehensive
overview
interrelationships
among
these
three
domains,
mechanisms
function
are
described,
detailing
regulates
system,
effects
duration
quality
responses,
underlying
molecular
cellular
mechanisms.
Also,
complex
relationship
immunity
is
explored,
highlighting
prevention
progression,
surveillance,
tumor
microenvironment,
implications
immunodeficiency
modulation
then
presenting
epidemiological
evidence
linking
to
risk,
biological
that
influence
development,
disorders
prognosis.
mediating
highlighted,
proposing
hypothesized
pathways,
summarizing
from
experimental
studies,
evaluating
impact
interventions
outcomes.
concludes
by
discussing
future
directions,
emphasizing
potential
for
sleep-based
treatment,
integration
management
oncology
immunotherapy,
outlining
agenda.
agenda
includes
understanding
sleep–immunity–cancer
interplay,
conducting
studies
assessing
treatment
protocols,
exploring
microenvironment
interactions,
considering
policy
public
health
Through
detailed
examination
interconnected
this
underscores
critical
importance
modulating
outcomes,
advocating
interdisciplinary
strategies
harness
improved
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(5)
Published: May 4, 2024
Abstract
Purpose
Acute
myeloid
leukemia
(AML)
is
a
refractory
hematologic
malignancy
that
poses
serious
threat
to
human
health.
Exploring
alternative
therapeutic
strategies
capable
of
inducing
modes
cell
death,
such
as
ferroptosis,
holds
great
promise
viable
and
effective
intervention.
Methods
We
analyzed
online
database
data
collected
clinical
samples
verify
the
expression
function
BMAL1
in
AML.
conducted
experiments
on
AML
proliferation,
cycle,
chemotherapy
resistance
by
overexpressing/knocking
down
using
assays
MDA
detection
BODIPY
581/591
C11
staining.
validated
transcriptional
regulation
HMGB1
through
ChIP
assay,
luciferase
RNA
level
detection,
western
blotting.
Finally,
we
confirmed
results
our
at
animal
level.
Results
up-regulation
an
observed
phenomenon
patients.
Furthermore,
there
existed
strong
correlation
between
elevated
levels
inferior
prognosis
individuals
with
found
knocking
inhibited
growth
blocking
cycle.
Conversely,
overexpressing
promoted
proliferation.
Moreover,
research
revealed
ferroptosis
cells
BMAL1-HMGB1-GPX4
pathway.
can
enhance
efficacy
certain
first-line
cancer
drugs,
including
venetoclax,
dasatinib,
sorafenib.
Conclusion
Our
suggest
plays
crucial
regulatory
role
drug
resistance,
ferroptosis.
could
be
potential
important
target
for
