Electrospun Polyvinylidene Fluoride-Based Fibrous Scaffolds with Piezoelectric Characteristics for Bone and Neural Tissue Engineering

Nanomaterials, Journal Year: 2019, Volume and Issue: 9(7), P. 952 - 952

Published: June 30, 2019

Polyvinylidene fluoride (PVDF) and polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE) with excellent piezoelectricity good biocompatibility are attractive materials for making functional scaffolds bone neural tissue engineering applications. Electrospun PVDF P(VDF-TrFE) can produce electrical charges during mechanical deformation, which provide necessary stimulation repairing defects damaged nerve cells. As such, these fibrous mats promote the adhesion, proliferation differentiation of cells on their surfaces. Furthermore, aligned enhance neurite growth along fiber orientation direction. These beneficial effects derive from formation electroactive, polar β-phase having piezoelectric properties. Polar be induced in fibers as a result polymer jet stretching poling electrospinning. Moreover, incorporation TrFE monomer into stabilize without or poling. The main drawbacks electrospinning process PVDF-based small pore sizes use highly toxic organic solvents. prevent infiltration neuronal scaffolds, leading to single cell layer scaffold Accordingly, modified methods such melt-electrospinning near-field have been explored by researchers tackle this issue. This article reviews recent development strategies, achievements major challenges electrospun

Language: Английский

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Polymers, Journal Year: 2020, Volume and Issue: 12(4), P. 844 - 844

Published: April 6, 2020

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, may not provide suitable support cell adhesion, proliferation, and differentiation, which decelerates regeneration. To improve biological properties, frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, cytokines. Although there many papers describing synthesis properties of polymer proteins or few reviews comprehensively summarize these molecules. Thus, this review presents the current knowledge about most important peptides used modification This paper also describes influence addition on physicochemical, mechanical, scaffolds. Moreover, article sums up major applications biodegradable natural synthetic modified have been developed within past five years.

Language: Английский

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Directional Freeze‐Casting: A Bioinspired Method to Assemble Multifunctional Aligned Porous Structures for Advanced Applications

Advanced Engineering Materials, Journal Year: 2020, Volume and Issue: 22(7)

Published: April 30, 2020

Herein, the potential of directional freeze‐casting techniques as a very generic, green, and straightforward approach for processing various functional porous materials is introduced. These include 3D monoliths, films, fibers, microspheres/beads, which are obtained by assembly network building blocks originated from cryoassembly aqueous‐based systems. The process simply relies on 1) freezing slurry through contact with cold surface, 2) maintaining at frozen state particular time controlling parameters directions, 3) sublimation created ice crystal templates inside developed structure to translate growth pattern final structure. such cryogenic contain highly complex structure, e.g., hierarchical well‐aligned microstructure in different levels, renders high control over physicochemical mechanical functionalities. Due versatility controllability this technique, can also be extended mimicking structures found natural bulk assemble bioinspired composites many useful physical features. aim, herein, give brief overview recent advances developing anisotropic inorganic, organic, hybrid, carbonaceous emphasis biomimicking using templating highlight their breakthrough high‐performance applications.

Language: Английский

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The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(7), P. 602 - 602

Published: June 29, 2020

Porous scaffolds have been employed for decades in the biomedical field where researchers seeking to produce an environment which could approach one of extracellular matrixes supporting cells natural tissues. Such three-dimensional systems offer many degrees freedom modulate cell activity, ranging from chemistry structure and architectural properties such as porosity, pore, interconnection size. All these features can be exploited synergistically tailor cell–material interactions, further, tissue growth within voids scaffold. Herein, overview materials generate porous well various techniques that are used process them is supplied. Furthermore, scaffold parameters behavior identified under distinct aspects: architecture inert (i.e., pore size, mechanical properties, etc.) alone on functions followed by comparison with bioactive grasp most relevant driving regeneration. Finally, vivo outcomes highlighted comparing accordance between vitro results order tackle future translational challenges repair

Language: Английский

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Angiogenesis in Tissue Engineering: As Nature Intended?

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 8

Published: March 20, 2020

Despite the steady increase in number of studies focusing on development tissue engineered constructs, solutions delivered to clinic are still limited. In particular, lack mature and functional vasculature, greatly limits size complexity scaffolds. If engineering aims at replacing large portions order repair significant defects, a more thorough understanding mechanisms players regulating angiogenic process is required field. This review will present current biological technological advancements addressing imperfect formation blood vessels within structures

Language: Английский

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Current Insights into Collagen Type I

Polymers, Journal Year: 2021, Volume and Issue: 13(16), P. 2642 - 2642

Published: Aug. 9, 2021

Collagen type I (Col-I) is unique due to its high biocompatibility in human tissue. Despite availability from various sources, Col-I naturally mimics the extracellular matrix (ECM) and generally makes up larger protein component (90%) vasculature, skin, tendon bone, other The acceptable physicochemical properties of native further enhance incorporation fields, including pharmaceutical, cosmeceutical, regenerative medicine, clinical. This review aims discuss Col-I, covering structure, sources availability, collagen synthesis, current extraction methods, characteristics, applications biomarkers. intended provide specific information on currently available, going back five years. expected a helping hand for researchers who are concerned about any development collagen-based products particularly therapeutic fields.

Language: Английский

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Recent advances in regenerative biomaterials

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring

Language: Английский

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Recent advances of polymer-based piezoelectric composites for biomedical applications

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2021, Volume and Issue: 122, P. 104669 - 104669

Published: June 29, 2021

Language: Английский

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Synthesis and evaluation of alginate, gelatin, and hyaluronic acid hybrid hydrogels for tissue engineering applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 233, P. 123438 - 123438

Published: Jan. 26, 2023

Tissue engineering (TE) has been proposed extensively as a potential solution to the worldwide shortages of donor organs needed for transplantation. Over years, numerous hydrogel formulations have studied various TE endeavours, including bone, cardiac or neural treatment strategies. Amongst materials used, organic and biocompatible which aim mimic natural extracellular matrix native tissue investigated create biomimicry regenerative environments. As such, comparison between studies using same is often difficult accomplish due varying material concentrations, preparation strategies, laboratory settings, such these variables huge impact on physio-chemical properties systems. The purpose current study investigate popular biomaterials alginate, hyaluronic acid gelatin in variety concentrations formulations. This aims provide clear comprehensive understanding their behaviours rational approach appropriate selection polysaccharides specific targeted

Language: Английский

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Chitosan-Based Biomaterials for Bone Tissue Engineering Applications: A Short Review

Polymers, Journal Year: 2022, Volume and Issue: 14(16), P. 3430 - 3430

Published: Aug. 22, 2022

Natural bone tissue is composed of calcium-deficient carbonated hydroxyapatite as the inorganic phase and collagen type I main organic phase. The biomimetic approach scaffold development for engineering application focused on mimicking complex characteristics. Calcium phosphates are used in numerous studies bioactive phases to mimic natural mineral. In order phase, synthetic (e.g., poly(ε-caprolactone), polylactic acid, poly(lactide-co-glycolide acid)) alginate, chitosan, collagen, gelatin, silk) biodegradable polymers used. However, materials obtained from sources accepted better by human organism, have attracted increasing attention. Over last three decades, chitosan was extensively studied a polymer suitable applications. Different types chitosan-based biomaterials molded macroporous, fiber-based, hydrogel, microspheres 3D-printed) with specific properties different regenerative applications were developed due chitosan's unique properties. This review summarizes state-of-the-art regeneration relevant composites.

Language: Английский

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