Physical Chemistry Chemical Physics,
Journal Year:
2023,
Volume and Issue:
25(15), P. 10697 - 10705
Published: Jan. 1, 2023
Investigating
the
protein
adhesion
properties
of
polymeric
scaffolds
through
computational
simulations
can
predict
biocompatibility
before
an
experimental
assay
is
carried
out.
This
prediction
be
highly
beneficial
since
it
cut
costs
and
time
takes
for
assays.
The
current
study
aims
to
test
hypothesis
that
there
a
correlation
between
composite
scaffold
molecular
dynamics
adhesion.
To
this
end,
chitosan
gelatin
were
selected
fabricating
skin-tissue
wound
with
five
different
polymer
ratios.
blend
has
not
been
simulated
cell
proliferation
viability
samples
quantified
via
MTT
using
fibroblast
cells.
Then
series
performed
measure
energy
two
prominent
extracellular
matrix
proteins
-
fibronectin,
collagen
type
I.
Besides,
higher
percentage
in
leads
decrease
porosity.
results
demonstrated
strong
data
simulations.
sample
equal
amounts
had
highest
strongest
energy,
239
kcal
mol-1
I,
149
fibronectin.
was
also
evident
other
samples:
gelatin-to-chitosan
ratios
3
:
1
lowest
weakest
respectively.
Advanced Composites and Hybrid Materials,
Journal Year:
2023,
Volume and Issue:
6(3)
Published: May 20, 2023
Abstract
Electrically
conductive
bio-scaffolds
are
explored
in
the
field
of
tissue
engineering
(TE)
as
a
solution
to
address
clinical
need
electroactive
tissues,
finding
applications
nervous,
cardiac,
and
spinal
cord
injury
repair.
In
this
work,
we
synthesise
polypyrrole
nanoparticles
(PPy
NP)
via
mini-emulsion
method
with
further
combination
gelatin/hyaluronic
acid
(HA)
hydrogel
create
electroconductive
Gel:HA:PPy-NP
TE
scaffolds.
Electroconductive
scaffolds
possess
excellent
mechanical
properties
at
1.08
±
0.26
MPa,
closely
matching
reported
performance
cord.
Scaffolds
were
designed
controlled
porosity
526.2
74.6–403.9
57.4
µm,
conductivities
4.3
×
10
–6
1.1
S.cm
−1
reached.
Rheological
studies
show
that
prior
lyophilisation,
hydrogels
display
shear-thinning
behaviour.
These
gels
subsequently
3D
printed
into
predefined
2
layer
lattice
geometries
displayed
post-printing
shape
fidelity.
vitro
cytocompatible
mesenchymal
stem
cells
neuronal
encouraging
cell
attachment
proliferation
profiles.
Based
on
these
results,
incorporation
PPy
NPs
Gel:HA
biomaterial
enhances
capabilities
material,
while
showcasing
biocompatible
behaviour
cultures.
Hence,
promising
option
for
stimulating
regeneration
following
nervous
injury.
Materials Science and Engineering R Reports,
Journal Year:
2024,
Volume and Issue:
159, P. 100799 - 100799
Published: April 30, 2024
Alginate,
a
polymer
mainly
derived
from
seaweed,
has
garnered
significant
attention
owing
to
its
renewability,
biocompatibility,
biodegradability,
and
exceptional
gel
formation
characteristics,
rendering
it
highly
versatile
for
numerous
applications.
Recognizing
the
imperative
tailored
bulk
materials,
this
review
scrutinizes
processing
methodologies
of
alginate-based
materials
delineates
strategies
improve
their
properties,
encompassing
ionic
crosslinking,
plasticization,
hybridization
with
other
polymers
and/or
fillers.
It
explores
noteworthy
blends
natural
like
polysaccharides
proteins,
alongside
fossil-based
poly(vinyl
alcohol).
also
examines
composites
incorporating
various
nanofillers
such
as
cellulose
nanoparticles,
graphene,
nanoclays.
The
techniques
these
multiphase
systems
encompass
solution
casting,
coating,
spinning,
3D
printing,
thermomechanical
processing.
Strategies
crosslinking
alginate,
plasticizing
it,
optimizing
interactions
polymers/fillers
are
outlined,
bearing
repercussions
on
resultant
properties.
This
emphasizes
structure–process–property
relationships
in
highlights
synergistic
effects
potential
impediments
property
improvements.
surveys
prospective
applications
multiphasic
spanning
membrane
separation,
controlled
release,
wound
healing,
tissue
engineering,
food
packaging,
agricultural
domains.
Finally
field,
knowledge
gaps
have
been
identified
future
research
directions
suggested.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(17), P. 7761 - 7778
Published: Jan. 1, 2024
Developing
injectable
hydrogel
dressings
with
multifunctional
properties,
including
antibacterial
and
antioxidant
ability,
good
mechanical
properties
to
treat
infected
full-thickness
skin
wounds
is
of
particular
importance
in
clinical
applications.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(13), P. 2989 - 3000
Published: Jan. 1, 2023
3D
bioprinting
of
a
gradient-stiffened
gelatin–alginate
hydrogel
accelerated
wound
healing
by
promoting
the
proliferation,
migration,
and
paracrine
secretion
encapsulated
ADSCs.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(19), P. 3940 - 3940
Published: Sept. 29, 2023
Vat
photopolymerization
(VP),
including
stereolithography
(SLA),
digital
light
processing
(DLP),
and
volumetric
printing,
employs
UV
or
visible
to
solidify
cell-laden
photoactive
bioresin
contained
within
a
vat
in
point-by-point,
layer-by-layer,
manner.
VP-based
bioprinting
has
garnered
substantial
attention
both
academia
industry
due
its
unprecedented
control
over
printing
resolution
accuracy,
as
well
rapid
speed.
It
holds
tremendous
potential
for
the
fabrication
of
tissue-
organ-like
structures
field
regenerative
medicine.
This
review
summarizes
recent
progress
VP
fields
tissue
engineering
First,
it
introduces
mechanism
photopolymerization,
followed
by
an
explanation
technique
commonly
used
biomaterials.
Furthermore,
application
was
discussed.
Finally,
challenges
facing
are
discussed,
future
trends
projected.
