Cells,
Journal Year:
2022,
Volume and Issue:
11(5), P. 901 - 901
Published: March 5, 2022
Inflammatory
bowel
diseases
(IBDs)
have
emerged
as
a
public
health
problem
worldwide
with
limited
number
of
efficient
therapeutic
options
despite
advances
in
medical
therapy.
Although
changes
the
gut
microbiota
composition
are
recognized
key
drivers
dysregulated
intestinal
immunity,
alterations
bile
acids
(BAs)
been
shown
to
influence
homeostasis
and
contribute
pathogenesis
disease.
In
this
review,
we
explore
interactions
involving
BAs
IBDs,
discuss
how
microbiota–BA–host
axis
may
digestive
inflammation.
Cells,
Journal Year:
2023,
Volume and Issue:
12(5), P. 793 - 793
Published: March 2, 2023
The
gut
microbiota,
including
bacteria,
archaea,
fungi,
viruses
and
phages,
inhabits
the
gastrointestinal
tract.
This
commensal
microbiota
can
contribute
to
regulation
of
host
immune
response
homeostasis.
Alterations
have
been
found
in
many
immune-related
diseases.
metabolites
generated
by
specific
microorganisms
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
(Trp)
bile
acid
(BA)
metabolites,
not
only
affect
genetic
epigenetic
but
also
impact
metabolism
cells,
immunosuppressive
inflammatory
cells.
cells
(such
tolerogenic
macrophages
(tMacs),
dendritic
(tDCs),
myeloid-derived
suppressive
(MDSCs),
regulatory
T
(Tregs),
B
(Breg)
innate
lymphocytes
(ILCs))
Macs
(iMacs),
DCs,
CD4
helper
(Th)1,
CD4Th2,
Th17,
natural
killer
(NK)
NK
neutrophils)
express
different
receptors
for
SCFAs,
Trp
BA
from
microorganisms.
Activation
these
promotes
differentiation
function
inhibits
causing
reprogramming
local
systemic
system
maintain
homeostasis
individuals.
We
here
will
summarize
recent
advances
understanding
effects
on
homeostasis,
especially
functions
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Feb. 5, 2023
Changes
in
the
composition
of
gut-associated
microbial
communities
are
associated
with
many
human
illnesses,
but
factors
driving
dysbiosis
remain
incompletely
understood.
One
factor
governing
microbiota
gut
is
bile.
Bile
acids
shape
through
their
antimicrobial
activity
and
by
activating
host
signaling
pathways
that
maintain
homeostasis.
Although
bile
host-derived,
functions
integrally
linked
to
bacterial
metabolism,
which
shapes
intestinal
acid
pool.
Conditions
change
size
or
pool
can
trigger
alterations
exacerbate
inflammation
favor
infection
opportunistic
pathogens.
Therefore,
manipulating
might
be
a
promising
strategy
remediate
dysbiosis.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Feb. 3, 2022
Inflammatory
bowel
disease
(IBD)
is
a
chronic
immune-mediated
inflammatory
disorder
of
the
gastrointestinal
tract
that
arises
due
to
complex
interactions
between
host
genetic
risk
factors,
environmental
and
dysbiotic
gut
microbiota.
Although
metagenomic
approaches
have
attempted
characterise
dysbiosis
occurring
in
IBD,
precise
mechanistic
pathways
interlinking
microbiota
intestinal
mucosa
are
still
yet
be
unravelled.
To
deconvolute
these
interactions,
more
reductionist
approach
involving
microbial
metabolites
has
been
suggested.
Bile
acids
emerged
as
key
class
microbiota-associated
perturbed
IBD
patients.
In
recent
years,
metabolomics
studies
revealed
consistent
defect
bile
acid
metabolism
with
an
increase
primary
reduction
secondary
This
review
explores
evolving
evidence
specific
interact
epithelial
immune
cells
contribute
milieu
seen
IBD.
Furthermore,
we
summarise
linking
intracellular
known
relevant
including
autophagy,
apoptosis,
inflammasome
pathway.
Finally,
discuss
how
novel
experimental
bioinformatics
could
further
advance
our
understanding
role
inform
therapeutic
strategies
Gastroenterology,
Journal Year:
2023,
Volume and Issue:
164(7), P. 1069 - 1085
Published: Feb. 24, 2023
The
human
gut
microbiome
has
been
linked
to
numerous
digestive
disorders,
but
its
metabolic
products
have
much
less
well
characterized,
in
part
due
the
expense
of
untargeted
metabolomics
and
lack
ability
process
data.
In
this
review,
we
focused
on
rapidly
expanding
information
about
bile
acid
repertoire
produced
by
microbiome,
including
impacts
acids
a
wide
range
host
physiological
processes
diseases,
discussed
role
short-chain
fatty
other
important
microbiome-derived
metabolites.
Of
particular
note
is
action
metabolites
throughout
body,
which
impact
ranging
from
obesity
aging
disorders
traditionally
thought
as
diseases
nervous
system,
that
are
now
recognized
being
strongly
influenced
it
produces.
We
also
highlighted
emerging
for
modifying
improve
health
or
treat
disease,
"engineered
native
bacteria''
approach
takes
bacterial
strains
patient,
modifies
them
alter
metabolism,
reintroduces
them.
Taken
together,
study
derived
provided
insights
into
pathophysiological
processes,
substantial
potential
new
approaches
diagnostics
therapeutics
disease
of,
involving,
gastrointestinal
tract.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 15, 2023
Bile
acids
(BAs)
as
cholesterol-derived
molecules
play
an
essential
role
in
some
physiological
processes
such
nutrient
absorption,
glucose
homeostasis
and
regulation
of
energy
expenditure.
They
are
synthesized
the
liver
primary
BAs
cholic
acid
(CA),
chenodeoxycholic
(CDCA)
conjugated
forms.
A
variety
secondary
deoxycholic
(DCA)
lithocholic
(LCA)
their
derivatives
is
intestine
through
involvement
various
microorganisms.
In
addition
to
functions,
metabolites
also
involved
differentiation
functions
innate
adaptive
immune
cells
macrophages
(Macs),
dendritic
(DCs),
myeloid
derived
suppressive
(MDSCs),
regulatory
T
(Treg),
Breg
cells,
helper
(Th)17
CD4
Th1
Th2
CD8
B
NKT
cells.
Dysregulation
affects
development
diseases
inflammatory
bowel
diseases.
We
here
summarize
recent
advances
how
maintain
gut
systemic
homeostasis,
including
metabolism
derivatives,
function
effects
on
immune-associated
disorders.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(1), P. 437 - 448
Published: Jan. 2, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
Increasing
evidence
suggests
higher
incidence
of
depression
in
IBD
patients
compared
with
the
general
population,
but
underlying
mechanism
remains
uncertain.
Rattan
pepper
polysaccharide
(RPP)
an
important
active
ingredient
rattan
pepper,
yet
its
effects
mechanisms
on
intestinal
inflammation
depression-like
behavior
remain
largely
unknown.
This
study
aims
to
investigate
ameliorating
effect
RPP
dextran
sulfate
sodium
salt
(DSS)-induced
as
well
reveal
mechanism.
Our
results
indicate
that
effectively
ameliorated
microbiota
imbalance
metabolic
disorders
short-chain
fatty
acids
(SCFAs)
bile
mice
DSS-induced
inflammation,
contributing
recovery
Th17/Treg
homeostasis.
Importantly,
alleviated
brain
caused
by
inflammatory
factors
entering
through
blood–brain
barrier.
may
be
attributed
inhibition
TLR4/NF-κB
signaling
pathway,
which
alleviates
neuroinflammation,
activation
CREB/BDNF
improves
synaptic
dysfunction.
Therefore,
our
findings
suggest
play
role
alleviating
gut
microbiota–gut–brain
axis.
Frontiers in Physiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Sept. 27, 2021
Inflammatory
bowel
diseases
(IBD)
are
chronic
medical
disorders
characterized
by
recurrent
gastrointestinal
inflammation.
While
the
etiology
of
IBD
is
still
unknown,
pathogenesis
disease
results
from
perturbations
in
both
gut
microbiota
and
host
immune
system.
Gut
dysbiosis
depleted
diversity,
reduced
abundance
short
chain
fatty
acids
(SCFAs)
producers
enriched
proinflammatory
microbes
such
as
adherent/invasive
E.
coli
H2S
producers.
This
may
contribute
to
inflammation
through
affecting
either
system
or
a
metabolic
pathway.
The
responses
extensively
discussed.
In
this
review,
we
highlight
main
pathways
that
regulate
host-microbiota
interaction.
We
also
discuss
reported
findings
indicating
microbial
during
has
potential
impact
on
colonocytes
underlie
progression.
Moreover,
present
defectiveness
adds
symbiont
will
raise
possibility
associated
with
functional
interactions,
consequently
modulates
development.
Finally,
shed
light
possible
therapeutic
approaches
targeting
microbiome.
