World Journal of Hepatology,
Journal Year:
2023,
Volume and Issue:
15(8), P. 985 - 1000
Published: Aug. 22, 2023
Recently,
a
group
of
hepatologists
proposed
to
rename
non-alcoholic
fatty
liver
disease
(NAFLD)
as
metabolic
associated
(MAFLD)
with
modified
diagnostic
criteria.
It
is
important
note,
however,
that
there
are
some
differences
between
the
criteria
used
for
NAFLD
and
MAFLD.
Since
research
on
MAFLD
just
beginning,
evidence
its
incidence
prevalence
in
general
population
specific
subpopulations
remains
limited.To
assess
epidemiology
new
definition
compare
NAFLD.
Exploring
risk
factors
individuals.This
was
retrospective,
cross-sectional
study.
A
total
85242
adults
were
selected
from
Chinese
health
management
database
2017-2022.
The
data
information,
laboratory
indicators,
lifestyle
psychological
status
obtained.
diagnosed
ultrasound
diagnosis
at
least
one
these
three
conditions:
Overweight/obesity,
type
2
diabetes
mellitus
(T2DM)
or
dysregulation.
Metabolic
not
considered
standard.
clinical
characteristics
analysed
using
descriptive
statistics.
Continuous
variables
normally
distributed
expressed
means
±
SD.
Categorical
frequencies
proportions.
Binary
logistic
regression
determine
MAFLD.The
40.5%
31.0%,
respectively.
more
likely
be
older
(M:
47.19
10.82
vs
43.43
11.96;
N:
47.72
11.17
43.71
11.66),
male
77.21%
44.43%;
67.90%
53.12%)
high
body
mass
index
26.79
2.69
22.44
2.48;
26.29
2.84
23.29
3.12)
than
non-MAFLD
population.
In
multivariate
analysis,
information
(e.g.,
≥
abnormalities
OR
=
3.38,
(95%CI:
2.99-3.81),
P
<
0.001;
diastolic
blood
pressure
1.01,
1.00-1.01),
0.002),
results
[e.g.,total
bilirubin
(TBIL)
0.98,
0.98-0.99),
serum
uric
acid(SUA)
1.01-1.01),
0.001],
[e.g.,
drink
beverage
0.32,
0.17-0.63),
0.001]
influence
Our
study
offer
insight
into
potential
disease,
including
SUA,
TBIL
creatinine,
all
which
related
chronic
renal
(CKD).MAFLD
prevalent
NAFLD,
two-fifths
individuals
meeting
populations
have
different
characteristics.
CKD
may
Liver International,
Journal Year:
2024,
Volume and Issue:
44(11), P. 2939 - 2949
Published: Aug. 19, 2024
Abstract
Importance
The
recent
change
in
terminology
from
nonalcoholic
fatty
liver
disease
(NAFLD)
to
metabolic
dysfunction‐associated
(MAFLD)
and
steatotic
(MASLD)
highlights
the
link
between
hepatic
steatosis
dysfunction,
taking
out
stigmata
of
alcohol.
Objective
We
compared
effects
NAFLD
MAFLD
definitions
on
risk
overall
cardiovascular
(CV)
mortality,
liver‐related
events
(LRE),
nonfatal
CV
(CVE),
chronic
kidney
(CKD),
extra‐hepatic
cancers
(EHC).
Data
Sources
Study
Selection
systematically
searched
four
large
electronic
databases
for
cohort
studies
(published
through
August
2023)
that
simultaneously
used
examining
mortality
adverse
CV,
renal,
or
oncological
outcomes
associated
with
both
definitions.
In
total,
21
eligible
were
identified.
Meta‐analysis
was
performed
using
random‐effects
modelling.
Results
Compared
those
NAFLD,
individuals
had
significantly
higher
rates
(random‐effect
OR
1.12,
95%
CI
1.04–1.21,
p
=
.004)
1.15,
1.04–1.26,
.004),
a
marginal
trend
towards
developing
CKD
1.06,
1.00–1.12,
.058)
EHC
1.11,
1.00–1.23,
.052).
found
no
significant
differences
LREs
CVE
NAFLD.
Meta‐regression
analyses
identified
male
sex
comorbidities
as
strongest
factors
related
clinical
Conclusions
Relevance
Individuals
have
than
possibly
due
dysmetabolic
profile
MAFLD.
Journal of Cardiovascular Development and Disease,
Journal Year:
2022,
Volume and Issue:
9(12), P. 419 - 419
Published: Nov. 26, 2022
Nonalcoholic
Fatty
Liver
Disease
(NAFLD)
is
a
growing
global
phenomenon,
and
its
damaging
effects
in
terms
of
cardiovascular
disease
(CVD)
risk
are
becoming
more
apparent.
NAFLD
estimated
to
affect
around
one
quarter
the
world
population
often
comorbid
with
other
metabolic
disorders
including
diabetes
mellitus,
hypertension,
coronary
artery
disease,
syndrome.
In
this
review,
we
examine
current
evidence
describing
many
ways
that
itself
increases
CVD
risk.
We
also
discuss
emerging
complex
biochemical
relationship
between
common
conditions,
how
they
coalesce
increase
With
NAFLD’s
rising
prevalence
deleterious
on
system,
complete
understanding
must
be
undertaken,
as
well
effective
strategies
prevent
treat
conditions.
Liver International,
Journal Year:
2022,
Volume and Issue:
43(3), P. 608 - 625
Published: Dec. 31, 2022
Abstract
Background
and
Aims
Cardiovascular
disease
(CVD)
is
the
main
cause
of
mortality
in
subjects
with
non‐alcoholic
fatty
liver
(NAFLD).
We
investigated
association
between
CVD
risk
metabolic
dysfunction‐associated
(MAFLD)
or
NAFLD
influence
significant
fibrosis
on
risk.
Methods
Subjects
who
underwent
a
comprehensive
medical
check‐up
were
recruited
(2014–2019).
Significant
was
defined
using
score,
fibrosis‐4
index,
aspartate
aminotransferase
to
platelet
ratio
FibroScan‐aspartate
score.
High
probability
atherosclerotic
(ASCVD)
as
ASCVD
score
>
10%.
Results
Of
study
population
(
n
=
78
762),
27
047
(34.3%)
24
036
(30.5%)
had
MAFLD
respectively.
A
total
1084
(4.0%)
921
(3.8%)
previous
history
subgroup
The
high
significantly
higher
than
other
groups
(all
p
<
.001).
In
multivariable
analysis,
independently
associated
after
adjusting
for
confounders
(adjusted
odds
[aOR]
1.10,
.038),
whereas
not
.05).
(aOR
1.40)
1.22)
full
adjustment
respectively
Conclusion
might
better
identify
NAFLD.
Fibrosis
assessment
be
helpful
detailed
prognostication
MAFLD.
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(15), P. 2081 - 2086
Published: April 19, 2024
Over
recent
years,
the
nomenclature
of
non-alcoholic
fatty
liver
disease
has
undergone
significant
changes.
Indeed,
in
2020,
an
expert
consensus
panel
proposed
term
"Metabolic
(dysfunction)
associated
disease"
(MAFLD)
to
underscore
close
association
with
metabolic
abnormalities,
thereby
highlighting
cardiometabolic
risks
(such
as
syndrome,
type
2
diabetes,
insulin
resistance,
and
cardiovascular
disease)
faced
by
these
patients
since
childhood.
More
recently,
this
been
further
replaced
steatotic
disease.
It
is
worth
noting
that
emerging
evidence
not
only
supports
a
independent
MAFLD
chronic
kidney
adults
but
also
indicates
its
interplay
impairments.
However,
comparable
pediatric
data
remain
limited.
Given
progressive
nature
both
diseases
their
prognostic
implications,
editorial
aims
provide
perspective
on
intriguing
relationship
between
renal
function
Journal of Hypertension,
Journal Year:
2024,
Volume and Issue:
42(10), P. 1785 - 1794
Published: June 25, 2024
Background:
Hypertension
development
is
predominantly
influenced
by
inflammation,
excessive
fat
deposition,
and
metabolic
irregularities.
Among
these
factors,
liver
accumulation
a
critical
disorder.
However,
the
quantification
of
levels
its
associated
risk
for
hypertension
incidence
remain
ambiguous.
This
project
designed
to
explore
association
between
in
healthy
population.
Methods:
cross-sectional
study
involved
4955
participants
from
Health
Management
Center
at
Henan
Provincial
People's
Hospital
who
were
surveyed
February
2020
2023.
Participants
categorized
into
four
groups
based
on
quartiles.
Subgroup
analyses,
restricted
cubic
spline
regression
models,
logistic
utilized
assess
risk.
The
relationships
inflammatory
markers
examined
using
multiple
linear
models.
Additionally,
mediation
analysis
was
conducted
role
factors
relationship
Results:
with
exhibited
greater
than
did
those
without
hypertension.
An
increased
elevated
levels,
even
after
adjusting
other
covariates
[Q4
vs.
Q1
model
II:
odds
ratio
(OR
=
1.28),
95%
confidence
interval
(CI)
1.04–1.59,
P
0.022;
trend
0.039].
A
nonlinear
observed
level
risk,
notable
increase
occurring
8.65%.
positive
correlation
found
levels.
effect
4.76%
noted,
linking
through
neutrophils.
Conclusion:
Liver
exceeding
8.65%
significantly
Inflammatory
serve
as
crucial
mediators
