The role of biomarkers in the assessment of aquatic ecosystem health

Integrated Environmental Assessment and Management, Journal Year: 2014, Volume and Issue: 10(3), P. 327 - 341

Published: Feb. 27, 2014

ABSTRACT Ensuring the health of aquatic ecosystems and identifying species at risk from detrimental effects environmental contaminants can be facilitated by integrating analytical chemical analysis with carefully selected biological endpoints measured in tissues concern. These include molecular, biochemical, physiological markers (i.e., biomarkers) that when integrated, clarify issues contaminant bioavailability, bioaccumulation, ecological while enabling a better understanding nonchemical stressors. In case stressors, an modes toxicity incorporated diagnostic animal physiology to help understand status organisms field. Furthermore, new approaches functional genomics bioinformatics discriminate individual chemicals, or groups chemicals among complex mixtures may contribute adverse effects. Although use biomarkers is not paradigm, such have been underused context assessment natural resource damage assessment. From regulatory standpoint, these assess coastal development activities assessing ecosystem integrity pre‐ post site remediation. Integr Environ Assess Manag 2014;10:327–341. © 2014 SETAC

Language: Английский

---

Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish

Chemosphere, Journal Year: 2015, Volume and Issue: 135, P. 38 - 45

Published: April 18, 2015

The occurrence of intersex fish, where male reproductive tissues show evidence feminization, have been found in freshwater systems around the world, indicating potential for significant endocrine disruption across species ecosystem. Estrogens from birth control medications wastewater treatment plant effluent cited as likely cause, but research has shown that is not solely predictable based on hormone receptor interactions. Many other non-hormone pharmaceuticals are at concentrations orders magnitude higher than estrogens, yet there little data impacts these medications. widely prescribed anti-diabetic metformin among most abundant and structurally dissimilar hormones. However, we here exposing fathead minnows (Pimephales promelas) to a concentration causes development gonads males, reduced size treated reduction fecundity pairs. Our results demonstrate acts an disruptor environmentally relevant concentrations.

Language: Английский

---

First national-scale reconnaissance of neonicotinoid insecticides in streams across the USA

Environmental Chemistry, Journal Year: 2015, Volume and Issue: 13(1), P. 12 - 12

Published: Aug. 18, 2015

Environmental context Neonicotinoids are under increased scrutiny because they have been implicated in pollinator declines and, more recently, as potential aquatic toxicants. Nevertheless, there is currently little information on concentrations of multiple neonicotinoids surface water. This paper presents a summary six streams from across the United States both urban and agricultural areas. These environmental data important determining risk to non-target terrestrial organisms. Abstract To better understand fate transport neonicotinoid insecticides, water samples were collected States. In nationwide study, at least one was detected 53% collected, with imidacloprid most frequently (37%), followed by clothianidin (24%), thiamethoxam (21%), dinotefuran (13%), acetamiprid (3%) thiacloprid (0%). Clothianidin positively related percentage land use cultivated crop production area within basin. Additional sampling also conducted targeted research areas complement these national-scale results, including determining: (1) during elevated flow conditions an intensely region; (2) temporal patterns heavily urbanised basins; (3) basins nationally ecosystem; (4) in-stream near wastewater treatment plant. Across all study areas, 63% 48 sampled.

Language: Английский

---

Biomarker for monitoring heavy metal pollution in aquatic environment: An overview toward molecular perspectives

Emerging contaminants, Journal Year: 2022, Volume and Issue: 8, P. 195 - 205

Published: Jan. 1, 2022

Water pollution is a significant problem in almost all parts of the world. The complexity anthropogenic activities along watershed seems to lead river function as giant disposal container. under threat degradation, mainly due heavy metal from actions. Heavy metals become harmful if they pollute waters since are accumulative, toxic, and carcinogenic water bodies biota. Various biomarkers evaluate contamination several aquatic organisms have been widely reported. use molecular more popular last years still for future prospect. Proteomics genomics with bioinformatics approaches expanded technological methods through DNA RNA sequencing mass spectrometry based proteomics. Therefore, this article aims review studies using biomarker many organisms. This expected reference encourage research, especially monitoring rivers.

Language: Английский

---

Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish

Environmental Toxicology and Chemistry, Journal Year: 2014, Volume and Issue: 34(2), P. 291 - 296

Published: Oct. 31, 2014

Abstract Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater surface waters around the world. A major source of these compounds is incomplete metabolism humans subsequent excretion human waste, resulting discharge into by treatment plant (WWTP) effluent. One pharmaceutical particularly high abundance recent WWTP effluent water studies metformin, one world's most widely prescribed antidiabetic drugs. Interactions between insulin signaling steroidogenesis suggest potential endocrine‐disrupting effects metformin aquatic environment. Adult fathead minnows ( Pimephales promelas ) were chronically exposed to for 4 wk, at 40 µg/L, a level similar average Milwaukee, Wisconsin, USA. Genetic endpoints related endocrine function as well reproduction‐related examined. Metformin induced significant up‐regulation messenger ribonucleic acid (mRNA) encoding egg‐protein vitellogenin male fish, an indication disruption. The present study, first study environmentally relevant exposure minnows, demonstrates need further organisms. Environ Toxicol Chem 2014;9999:1–6. © 2014 Authors. Published Wiley Periodicals, Inc. on behalf SETAC.

Language: Английский

---

Occurrence of antibiotics, estrogenic hormones, and UV-filters in water, sediment, and oyster tissue from the Chesapeake Bay

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 650, P. 3101 - 3109

Published: Oct. 3, 2018

Language: Английский

---

Intersex in teleost fish: Are we distinguishing endocrine disruption from natural phenomena?

General and Comparative Endocrinology, Journal Year: 2013, Volume and Issue: 192, P. 25 - 35

Published: April 18, 2013

Language: Английский

---

Effects of Atrazine in Fish, Amphibians, and Reptiles: An Analysis Based on Quantitative Weight of Evidence

Critical Reviews in Toxicology, Journal Year: 2014, Volume and Issue: 44(sup5), P. 1 - 66

Published: Nov. 6, 2014

A quantitative weight of evidence (WoE) approach was developed to evaluate studies used for regulatory purposes, as well those in the open literature, that report effects herbicide atrazine on fish, amphibians, and reptiles. The methodology WoE analysis incorporated a detailed assessment relevance responses observed apical endpoints directly related survival, growth, development, reproduction, strength appropriateness experimental methods employed. Numerical scores were assigned relevance. means then summarize weigh contributing ecologically significant organisms interest. summary presented graphically two-dimensional graph which showed distributions all reports response. Over 1290 individual from 31 species 32 8 reptiles evaluated. Overall, might affect biomarker-type responses, such expression genes and/or associated proteins, concentrations hormones, biochemical processes (e.g. induction detoxification responses), at sometimes found environment. However, these not translated adverse outcomes terms endpoints. provided quantitative, transparent, reproducible, robust framework can be assist decision-making process when assessing environmental chemicals. In addition, allowed easy identification uncertainty inconsistency observations, thus clearly identified areas where future investigations best directed.

Language: Английский

---

Pharmaceuticals and personal care products: A critical review of the impacts on fish reproduction

Critical Reviews in Toxicology, Journal Year: 2015, Volume and Issue: 45(6), P. 469 - 491

Published: May 6, 2015

Research in environmental toxicology involving pharmaceuticals and personal care products (PPCPs) has increased greatly over the last 10–15 years. Much research been focused on endocrine-disrupting potential of PPCPs, as they relate to negative population impacts aquatic organisms. This review assesses current data reported effects PPCPs fish reproduction with an emphasis fecundity, a predictor effects. Studies both individual PPCP mixtures are presented. As majority studies reviewed demonstrate we these findings detected surface water concentrations compounds. Very few have conducted; however, need for types is warranted most likely exposed wild. In addition, laboratory field assessments wastewater treatment plant (WWTP) effluents, major source reviewed. provided from variable do not generally reproduction, or unable directly associate observed WWTP effluents. Finally, future considerations outlined provide avenue into understanding how wild populations affected by PPCPs. These aimed at determining adaptation multiple generations. global use continually rises, discern chronic exposure increased.

Language: Английский

---

Prioritizing chemicals of ecological concern in Great Lakes tributaries using high-throughput screening data and adverse outcome pathways

The Science of The Total Environment, Journal Year: 2019, Volume and Issue: 686, P. 995 - 1009

Published: June 5, 2019

Chemical monitoring data were collected in surface waters from 57 Great Lakes tributaries 2010 to 13 identify chemicals of potential biological relevance and sites at which these occur. Traditional water-quality benchmarks for aquatic life based on vivo toxicity available 34 67 evaluated chemicals. To expand evaluation effects, measured chemical concentrations compared chemical-specific activities determined high-throughput (ToxCast) vitro assays. Resulting exposure-activity ratios (EARs) used prioritize the greatest concern: 4‑nonylphenol, bisphenol A, metolachlor, atrazine, DEET, caffeine, tris(2‑butoxyethyl) phosphate, tributyl triphenyl benzo(a)pyrene, fluoranthene, benzophenone. Water-quality unavailable five chemicals, but remaining seven, EAR-based prioritization was consistent with that quotients calculated benchmarks. identified three additional PAHs (anthracene, phenanthrene, pyrene) not prioritized using EARs. Through this analysis, an EAR 10-3 as a reasonable threshold above might be concern. better understand apical hazards potentially associated captured ToxCast assays, bioactivity matched adverse outcome pathway (AOP) information. The 49 assays via analysis aligned 23 potentially-relevant AOPs present AOP-Wiki. Mixture effects monitored estimated by summation values multiple individual assay or AOP. Commonly predicted outcomes included impacts reproduction mitochondrial function. approach provided screening-level assessment evidence-based effects. aids future provides testable hypotheses help focus those efforts. This also expands fraction detected biologically-based benchmark are contextualize results.

Language: Английский

---