Current knowledge of hybrid nanoplatforms composed of exosomes and organic/inorganic nanoparticles for disease treatment and cell/tissue imaging

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117248 - 117248

Published: Aug. 3, 2024

Exosome-nanoparticle hybrid nanoplatforms, can be prepared by combining exosomes with different types of nanoparticles. The main purpose nanoparticles is to overcome the limitations using each them as drug delivery systems. Using for has some limitations, such high immunogenicity, poor cellular uptake, low biocompatibility, cytotoxicity, stability, and rapid clearance immune cells. However, systems also its own drawbacks, encapsulation efficiency, production yield, inability load large molecules. These addressed utilizing nanoplatforms. Additionally, use allows targeted within system. Exosome-inorganic/organic may used both therapy diagnosis in future. This lead development personalized medicine there are a few challenges associated this. Surface modifications, adding functional groups, surface charge adjustments, preparing desired size crucial possibility exosome-nanoparticle hybrids. Additional successful implementation platforms medical treatments diagnostics include scaling up manufacturing process ensuring consistent quality reproducibility across various batches. review focuses on discusses preparation loading methods these Furthermore, potential applications nanocarriers drug/gene delivery, disease treatment diagnosis, cell/tissue imaging explained.

Language: Английский

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Fusion of Exosomes and Nanotechnology: Cutting-Edge Cancer Theranostics

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8489 - 8506

Published: April 15, 2024

Cancer is the most challenging health complication worldwide. Scientific society has tried to decode its complications and developing a smart solution for mankind. Extracellular vesicles (EVs) are an emerging frontier in cancer research. EVs provide fresh insight into understanding of released from all active cells. classified some major classes, such as apoptotic bodies, microvesicles, exosomes. Exosomes among exciting tools current research they work cellular messengers (which reflects cell's healthy or pathological conditional status). In tumor microenvironment, regulate several complicated events uncontrolled cell growth, immune suppression, angiogenesis, extracellular matrix remodeling, metastasis, organ-specific drug therapeutic resistance, stem development. also source promising biomarkers involved both diagnosis prognosis performs role. Exosomes-based nanomedicine which application nanosize theranostics sensor orientation, supports overcoming management limitations, early therapeutics specific, effective, affordable. this review, we have highlighted integration exosomes nanotechnology cutting-edge approach precision oncology.

Language: Английский

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Exosomal noncoding RNA: A potential therapy for retinal vascular diseases

Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(1), P. 102128 - 102128

Published: Jan. 24, 2024

Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They secreted by cells play a regulatory role in various biological responses mediating cell-to-cell communication. Moreover, exosomes of interest developing therapies for retinal vascular disorders because they deliver substances to cellular targets. According recent research, be used as strategy managing diseases, being investigated therapeutic purposes eye conditions, including glaucoma, dry syndrome, ischemia, diabetic retinopathy, age-related macular degeneration. However, the exosomal noncoding RNA diseases is not fully understood. Here, we reviewed latest research on treating diseases. Research has shown RNAs, microRNAs, circular long RNAs significant regulation Furthermore, through exosome engineering, expression relevant controlled regulate Therefore, this review suggests could considered biomarker diagnosis target disease.

Language: Английский

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Exosome may be the next generation of promising cell-free vaccines

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: May 7, 2024

Traditional vaccines have limits against some persistent infections and pathogens. The development of novel vaccine technologies is particularly critical for the future. Exosomes play an important role in physiological pathological processes. present many advantages, such as inherent capacity being biocompatible, non-toxic, which make them a more desirable candidate vaccines. However, research on exosomes are their infancy barriers low yield, purity, weak targeting limit applications Accordingly, further exploration necessary to improve these problems subsequently facilitate functional studies exosomes. In this study, we reviewed origin, classification, functions, modifications, separation purification, characterization methods Meanwhile, focused mechanism cancer COVID-19

Language: Английский

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Exosome-based nanoparticles and cancer immunotherapy

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117296 - 117296

Published: Aug. 20, 2024

Over the past decades, cancer immunotherapy has encountered challenges such as immunogenicity, inefficiency, and cytotoxicity. Consequently, exosome-based gained rapid traction a promising alternative. Exosomes, type of extracellular vesicles (EVs) ranging from 50 to 150 nm, are self-originating exhibit fewer side effects compared traditional therapies. Exosome-based encompasses three significant areas: vaccination, co-inhibitory checkpoints, adoptive T-cell therapy. Each these fields leverages inherent advantages exosomes, demonstrating substantial potential for individualized tumor therapy precision medicine. This review aims elucidate reasons behind promise nanoparticles therapies by examining their characteristics summarizing latest research advancements in immunotherapy.

Language: Английский

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