The effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: a systematic review and meta-analysis of randomized controlled trials

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107398 - 107398

Published: Sept. 4, 2024

Language: Английский

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Effect of Probiotics on C-Reactive Protein Levels in Schizophrenia: Evidence from a Systematic Review and Meta-Analysis

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103126 - 103126

Published: Jan. 1, 2025

Inflammatory markers play a pivotal role in schizophrenia, as they provide insight into the neuroinflammatory processes occurring context of disorder. Elevated levels these markers, particularly C-reactive protein (CRP), can indicate an underlying immune system dysregulation, potentially influencing symptom severity and progression. Recognizing has led to investigate use probiotics adjuvant improve treatment schizophrenia. The main objective this study is rigorously evaluate efficacy reducing plasma CRP patients with A systematic search meta-analysis were conducted review randomized clinical trials following PRISMA methodology. strategy ((SCHIZO* OR PSYCHOTIC PSYCHOSES) AND (PROBIOTIC* BIFIDOBACTER* LACTOBACILL*)) was used for searching publications between June-December 2024 on PubMed, Web Science, APA PsycINFO databases. Individual quality assessed Cochrane risk bias (RoB2) certainty total evidence GRADE system. primary outcome impact probiotic supplementation levels. Out 78 studies initially identified, 4 finally included meta-analysis. Three out four found significant reduction high-sensitivity supplemented compared placebo group. pooled analysis revealed supplementation, standardized mean difference (SMD) -0.46, (95% CI -0.719; -0.201; p = 0.001). synthesis available literature potential serum schizophrenia placebo. However, more better control experimental design are needed before clear recommendation therapy be made.

Language: Английский

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Limited Changes in Red Blood Cell Parameters After Probiotic Supplementation in Depressive Individuals: Insights from a Secondary Analysis of the PRO-DEMET Randomized Controlled Trial

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(1), P. 265 - 265

Published: Jan. 5, 2025

Background: Depression often coexists with anemia, potentially sharing common pathways, highlighting the need for treatments addressing both conditions simultaneously. This study evaluated effect of probiotics on red blood cell (RBC) parameters in adults depressive disorder. We hypothesized that would positively influence RBC parameters, modulated by baseline inflammation or dietary intake, improved function correlating better antidepressant outcomes. Methods: secondary analysis a two-arm, randomized, double-blind, controlled trial involved 116 Participants received probiotic formulation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 placebo 60 days. Data from 97 subjects were analyzed including hemoglobin (HGB), count, hematocrit (HCT), mean corpuscular volume (MCV), concentration (MCH), (MCHC), distribution width (RDW). Results: Probiotic supplementation did not result significant changes compared to placebo. However, may help stabilize HGB, HCT, MCH, MCHC levels, preventing fluctuations observed group. Conclusions: While showed potential benefits symptoms, observed. Larger studies are needed clarify mechanisms clinical implications.

Language: Английский

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Impact of Probiotics on Triglyceride Level After Bariatric Surgery: A Trial Sequential Analysis

Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

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Impact of Ligilactobacillus salivarius Li01 on benzo[a]pyrene-induced colitis, based on host-microbiome interactions in Mongolian gerbils

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Probiotics supplementations have been regarded as an effective strategy for colitis treatment. However, the effect of Ligilactobacillus salivarius Li01 on benzo[a]pyrene (BaP)-induced in Mongolian gerbils remains unclear. In this study, we leverage a BaP-induced model that exhibits significant remission following intervention, to conduct animal experiment integrates histopathological assessment, inflammatory cytokines, 16S rRNA sequencing, targeted metabolomic profiling investigate relationship between Li01, gut microbiota, and colitis. We demonstrated improvements colon assessment cytokines by supplementation are accompanied alterations microbiota structure marked increased abundance strains with probiotic potential belonging Bifidobacterium Eubacterium_coprostanoligenes. Targeted analysis showed increases concentration acetic, propionic, butyric, valeric acid. Correlation alteration indicators associated is closely correlated changed microbial taxa short-chain fatty acids (SCFAs). These data highlighted ameliorated colitis, probably via modulating promoting production SCFAs. Our findings provide preliminary evidence possible therapeutic treatment based host-microbiome interactions.

Language: Английский

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The impact of probiotics on oxidative stress and inflammatory markers in patients with diabetes: a meta-research of meta-analysis studies

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 7, 2025

Objective Probiotic supplementation has gained attention for its potential to modulate inflammatory and oxidative stress biomarkers, particularly in metabolic disorders. This meta-analysis evaluates the effects of probiotics on C-reactive protein (CRP), tumor necrosis factor-alpha (TNF- α ), interleukin-6 (IL-6), malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH), nitric oxide (NO) patients with diabetes. Methods A Meta-Research was conducted 15 meta-analyses unique 33 randomized controlled trials (RCTs) published between 2015 2022, involving 26 136 participants aged 66 years. Data were synthesized using standardized mean differences (SMD), sensitivity analysis a random-effect model. Results significantly reduced CRP (SMD = −0.79, 95% CI: −1.19, −0.38), TNF- −1.35, −2.05, −0.66), MDA levels (WMD: -0.82, −1.16, −0.47). Probiotics increased GSH 1.00, 0.41, 1.59), TAC 0.48, 0.27, 0.69), NO 0.60, 0.30, 0.91). Result IL-6 not significant −0.29, −0.66, 0.09). Sensitivity analyses confirmed robustness. Conclusion improved biomarkers diabetes, variations influenced by population dosage. Future studies should explore novel probiotic strains longer interventions.

Language: Английский

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The Effect of Probiotic Supplementation Over Cytokine Modulation in Athletes After a Bout of Exercise: A Systematic Review and Meta-Analysis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background Exercise-induced inflammation, especially after intense or prolonged physical activity, can hinder recovery in athletes. Probiotic supplementation has been suggested as a potential method to modulate this inflammatory response by influencing the gut microbiota. However, effects of probiotics on cytokine profiles following exercise remain unclear. This systematic review and meta-analysis aimed assess impact probiotic modulation athletes aged 18–50 years exercise. Methods Randomized controlled trials (RCTs) that administered for at least one week were included. Studies comparing placebo no supplementation, with post-exercise levels primary outcome, analyzed. A search was conducted across four databases up June 2024. Risk bias assessed using McMaster Critical Review Form, random-effects meta-analyses performed determine supplementation. Results total 19 studies involving 526 from various endurance disciplines included review. significantly increased anti-inflammatory interleukin-10 (IL-10) (SMD = 0.43; 95% CI: 0.25 0.61; I² 0%). significant observed other cytokines, including IL-1β, IL-6, IL-8, TNF-α, IFN-γ. Subgroup analyses supported consistency IL-10 findings different protocols, though substantial heterogeneity some cytokines. The variability study designs, strains, dosages, modalities contributed mixed results. Conclusion appears enhance responses post-exercise, particularly increasing levels, which may aid evidence regarding its pro-inflammatory cytokines remains inconclusive. Further well-designed RCTs are needed clarify these establish standardized protocols

Language: Английский

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Comparison of the efficacy of fish oil and probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes: a systematic review and network meta-analysis

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 22, 2024

Abstract Background Abnormalities in glucose and lipid metabolism contribute to the progression exacerbation of type 2 diabetes mellitus (T2DM). Fish oil probiotics are dietary supplements that have potential improve metabolism. However, their efficacy remains unclear T2DM patients. Methods PubMed, Embase, Cochrane Library were retrieved collect randomized controlled trials (RCTs) on fish or probiotic supplementation patients from database inception December 13, 2023. Primary outcome indicators encompassed glycated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR) blood profile (triglyceride (TG) total cholesterol (TC). Secondary included inflammatory markers such as tumor necrosis factor -α (TNF-α) adipocytokine (including leptin adiponectin). The R software was used statistical analysis, GraphPad Prism figure rendering. Results A 60 RCTs involving 3845 analysis. results showed ( Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium, etc . ) more effective reducing HOMA-IR than (Surca = 0.935). Bifidobacterium demonstrated highest HbA1c levels 0.963). Regarding metabolism, superior lowering TG TC values 0.978 0.902, respectively). Furthermore, outperformed TNF-α 0.839) 0.712), increasing adiponectin 0.742). Node-splitting analysis good consistency (P > 0.05 direct, indirect, network comparison across various interventions). Conclusions In patients, regulating Probiotics particularly; specifically, higher glucose.

Language: Английский

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Effects of probiotic treatment on patients and animals with chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized control trials

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 11, 2024

In recent years, the lung-gut axis has received increasing attention. The oxidative stress and systemic hypoxia occurring in chronic obstructive pulmonary disease (COPD) are related to gut dysfunction. That suggests probiotics have a potential therapeutic role COPD. this study, we therefore evaluated ameliorative effects of on

Language: Английский

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Preventive effect of probiotics on oral mucositis induced by anticancer therapy: a systematic review and meta-analysis of randomized controlled trials

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 29, 2024

Language: Английский

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