International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1699 - 1707
Published: Feb. 1, 2024
Introduction:
The
presence
of
cancer
stem
cells
(CSCs)
significantly
limits
the
therapeutic
efficacy
radiotherapy
(RT).
Efficient
elimination
potential
CSCs
is
crucial
for
enhancing
effectiveness
RT.
Methods:
In
this
study,
we
developed
a
biomimetic
hybrid
nano-system
(PMC)
composed
MnCO
3
as
inner
core
and
platelet
membrane
(PM)
outer
shell.
By
exploiting
specific
recognition
properties
surface
proteins,
PMC
enables
precise
targeting
CSCs.
Sonodynamic
therapy
(SDT)
was
employed
using
manganese
carbonate
nanoparticles
(MnCO
NPs),
which
generate
abundant
reactive
oxygen
species
(ROS)
upon
ultrasound
(US)
irradiation,
thereby
impairing
CSC
self-renewal
capacity
eradicating
Subsequent
RT
effectively
eliminates
common
tumor
cells.
Results:
Both
in
vitro
cell
experiments
vivo
animal
studies
demonstrate
that
SDT
mediated
by
synergistically
enhances
to
selectively
combat
while
inhibiting
growth
without
noticeable
side
effects.
Discussion:
Our
findings
offer
novel
insights
safety
profiles
Keywords:
clearance,
radiosensitization,
membrane,
sonodynamic
therapy,
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5196 - 5196
Published: May 10, 2024
The
treatment
of
chronic
wounds
involves
precise
requirements
and
complex
challenges,
as
the
healing
process
cannot
go
beyond
inflammatory
phase,
therefore
increasing
time
implying
a
higher
risk
opportunistic
infection.
Following
better
understanding
process,
oxygen
supply
has
been
validated
therapeutic
approach
to
improve
speed
up
wound
healing.
Moreover,
local
implications
antimicrobial
agents
(such
silver-based
nano-compounds)
significantly
support
normal
by
combating
bacterial
contamination
colonization.
In
this
study,
silver
(S)
tannylated
calcium
peroxide
(CaO2@TA)
nanoparticles
were
obtained
adapted
microfluidic
precipitation
synthesis
methods,
respectively.
After
complementary
physicochemical
evaluation,
both
types
loaded
in
(Alg)
alginate-based
gels
that
further
evaluated
possible
dressings
for
composites
showed
porous
structure
uniform
distribution
through
polymeric
matrix
(evidenced
spectrophotometric
analysis
electron
microscopy
studies),
together
with
good
swelling
capacity.
as-proposed
gel
exhibited
constant
suitable
concentration
released
oxygen,
shown
eight
hours
(UV-Vis
investigation).
biofilm
modulation
data
indicated
synergistic
effect
between
nanoparticles,
prominent
inhibitory
action
against
Gram-positive
after
48
h.
Beneficial
effects
human
keratinocytes
cultured
contact
materials
demonstrated
performed
tests,
such
MTT,
LDH,
NO.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(18), P. 8739 - 8758
Published: Jan. 1, 2024
Lactate
oxidase
(LOX)
is
a
natural
enzyme
that
efficiently
consumes
lactate.
In
the
presence
of
oxygen,
LOX
can
catalyse
formation
pyruvate
and
hydrogen
peroxide
(H
REVIEWS ON ADVANCED MATERIALS SCIENCE,
Journal Year:
2023,
Volume and Issue:
62(1)
Published: Jan. 1, 2023
Abstract
In
recent
years,
calcium
peroxide
(CaO
2
)
has
attracted
widespread
attention
in
the
medical
community
due
to
its
excellent
antitumor
and
antibacterial
properties,
gradually
become
a
hot
research
topic
biomedical
field.
CaO
reacts
with
water
(H
O)
produce
ion
(Ca
2+
),
oxygen
(O
hydrogen
O
where
Ca
is
suitable
for
death
caused
by
overload,
-dependent
anticancer
therapy,
H
therapy.
addition,
can
also
be
used
field
treat
bacterial
infections.
All
these
make
kind
of
drug.
This
study
mainly
reviews
preparation
surface
modification
,
probes
into
latest
progress
about
nanoparticles
tumor
treatment
antimicrobial
Finally,
challenges
that
still
faces
future
are
clarified,
prospects
forecasted.
