In Vitro and In Vivo Evaluation of a Polycaprolactone (PCL)/Polylactic-Co-Glycolic Acid (PLGA) (80:20) Scaffold for Improved Treatment of Chondral (Cartilage) Injuries

Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2324 - 2324

Published: May 16, 2023

Articular cartilage is a specialized tissue that provides smooth surface for joint movement and load transmission. Unfortunately, it has limited regenerative capacity. Tissue engineering, combining different cell types, scaffolds, growth factors, physical stimulation become an alternative repairing regenerating articular cartilage. Dental Follicle Mesenchymal Stem Cells (DFMSCs) are attractive candidates engineering because of their ability to differentiate into chondrocytes, on the other hand, polymers blend like Polycaprolactone (PCL) Poly Lactic-co-Glycolic Acid (PLGA) have shown promise given mechanical properties biocompatibility. In this work, physicochemical polymer blends were evaluated by Fourier Transform Infrared Spectroscopy (FTIR) Scanning Electron Microscope (SEM) positive both techniques. The DFMSCs demonstrated stemness flow cytometry. scaffold showed be non-toxic effect when we with Alamar blue, samples analyzed using SEM phalloidin staining evaluate adhesion scaffold. synthesis glycosaminoglycans was construct in vitro. Finally, PCL/PLGA better repair capacity than two commercial compounds, tested chondral defect rat model. These results suggest (80:20) may suitable applications hyaline

Language: Английский

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Explorations of structural and electronic features of an enhanced iron-doped boron nitride nanocage for adsorbing/sensing functions of the hydroxyurea anticancer drug delivery under density functional theory calculations

Physica B Condensed Matter, Journal Year: 2023, Volume and Issue: 671, P. 415445 - 415445

Published: Oct. 21, 2023

Language: Английский

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Stem Cells from Human Exfoliated Deciduous Teeth-Derived Exosomes for the Treatment of Acute Liver Injury and Liver Fibrosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Mesenchymal stem cells (MSCs) play a crucial role in regenerative medicine due to their potential. However, traditional MSC-based therapies are hindered by issues such as microvascular obstruction and low cell survival after transplantation. Exosomes derived from MSCs (MSC-Exo) provide cell-free, nanoscale alternative, mitigating these risks offering therapeutic potential for liver diseases. Nonetheless, the functional variability of different sources complicates clinical application. Stem human exfoliated deciduous teeth (SHED) offer advantages ease procurement robust proliferative capacity, but secretome, particularly SHED-Exo, remains underexplored context disease therapy. This study analyzed MSC-Exo various via small RNA sequencing identify differences microRNA profiles, aiding selection optimal MSC use. SHED-Exo was subsequently tested an acute injury model, showing notable effects, including enhanced hepatocyte proliferation, macrophage polarization, reduced inflammation. Despite strong liver-targeting properties, rapid hepatic clearance limits its effectiveness chronic To address this challenge, GelMA-based hydrogel developed situ delivery, ensuring sustained release antifibrotic efficacy, providing promising strategy management.

Language: Английский

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Smart injectable hydrogels for periodontal regeneration: Recent Advancements in Biomaterials and Biofabrication Strategies

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101855 - 101855

Published: May 1, 2025

Language: Английский

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Growth and size of stem cells from human exfoliated deciduous teeth cultured in platelet lysate vs. fetal bovine serum for regenerative applications

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: May 21, 2025

Stem cells from human exfoliated deciduous teeth (SHED) can differentiate into functioning neurons and oligodendrocytes exhibit immunomodulatory regenerative properties. This study aimed to compare the growth size of SHED cultured in platelet lysate (hPL) fetal bovine serum (FBS), with goal evaluating their potential use medicine. Healthy uninflamed pulp were used for culture. Growth, proliferation, morphology SHED, as well mean surface area, length, width cells, compared between FBS hPL. The area was lower on than hPL days 4, 6, 9 passage 0, higher day 2, comparable 5 10. Comparison growth, 3 0 showed no significant difference. In addition, there difference regarding same passages 1, 3, 4. total length within 10 (137.9 vs. 148.1 µm), while (28 26 µm). overall after 0. Therefore, appear be relatively similar culture replace this purpose.

Language: Английский

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Density functional theory assessments of an iron-doped graphene platform towards the hydrea anticancer drug delivery

Diamond and Related Materials, Journal Year: 2023, Volume and Issue: 141, P. 110683 - 110683

Published: Nov. 30, 2023

Language: Английский

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Unlocking the Future: Bioprinting Salivary Glands—From Possibility to Reality

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(6), P. 151 - 151

Published: June 1, 2024

Salivary gland biofabrication represents a promising avenue in regenerative medicine, aiming to address the challenges of salivary dysfunction caused by various factors such as autoimmune diseases and radiotherapy. This review examines current state bioprinting technology, biomaterials, tissue engineering strategies context creating functional, implantable constructs. Key considerations include achieving vascularization for proper nutrient supply, maintaining cell viability functionality during printing, promoting maturation integration with surrounding tissues. Despite existing challenges, recent advancements offer significant potential development personalized therapeutic options treat disorders. Continued research innovation this field hold revolutionize management conditions, improving patient outcomes quality life. systematic covers publications from 2018 April 2024 was conducted on four databases: Google Scholar, PubMed, EBSCOhost, Web Science. The key features necessary successful creation, implantation functioning bioprinted glands are addressed.

Language: Английский

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A critical review of dental biomaterials with an emphasis on biocompatibility

Dental and Medical Problems, Journal Year: 2023, Volume and Issue: 60(4), P. 709 - 739

Published: Dec. 15, 2023

This paper presents the major achievements in field of biomaterials restorative dentistry and tissue regeneration reported over past 3 years. The review aims to summarize knowledge on important emerging modification strategies improve their biointegration, biological activity, mechanical properties, resistance harsh oral environment. We also discuss main opportunities challenges associated with use dentistry.Much contemporary research focuses interactions between surrounding tissues environment regarding adhesion, stresses strains, durability dental restoration materials. Dental should support cell adhesion leading regeneration, are expected effectively prevent bacterial infections inhibit material corrosion saliva. degradation, dissolution or materials due exposure body fluids can alter structure properties material, causing various adverse effects.Another aspect addressed recent literature is improvement esthetics surfaces usually modified polymers nanomaterials reduce friction while maintaining biocompatibility.Although all modern promising, there an urgent need for more vivo clinical studies investigate advantages disadvantages detail. computational techniques used assess materials, particularly ones, could assist development Such approach help bring new market by reducing complicated, tedious expensive experimentation.

Language: Английский

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The effects of Kinesio tapes on facial swelling following bimaxillary orthognathic surgery in the supraclavicular region

Maxillofacial Plastic and Reconstructive Surgery, Journal Year: 2023, Volume and Issue: 45(1)

Published: June 19, 2023

Several osteotomies are required for orthognathic surgery to reposition the jaws correctly. This study aimed evaluate whether Kinesiotaping can reduce swelling, pain, and trismus following of facial skull.The present consists two phases. In split-mouth phase, 16 skeletal class III patients underwent Bimax Orthognathic surgery, Kinesiological tape (KT) was applied on one half face. prospective case-control 30 were divided into groups. Kinesio both sides face group, pressure dressing ice therapy used second group. The parallel lower border mandible along its entire length, tangent labial commissure area studied side. placed in place 5 days. Edema evaluated by measuring distance from menton edge tragus. maximum mouth-opening evaluated, VAS index pain.There evidence swelling reduction after KT; within same study, differences between left right as well side statistically significant (p < 0.001). As a result tapping lymphatic affected area, tension reduced, circulation restored. Blood lymph microcirculation improved, enabling body heal itself.Kinesio reduced positive way. simple, non-traumatic, economical method, taping seems promising.

Language: Английский

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Success in Tooth Bud Regeneration: A Short Communication

Journal of Endodontics, Journal Year: 2023, Volume and Issue: 50(3), P. 351 - 354

Published: Dec. 27, 2023

Language: Английский

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