Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)
Published: Nov. 25, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4679 - 4679
Published: April 25, 2024
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) strongly attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. upregulated hypoxia and/or inflammation-induced inflammatory release, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis, migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.
Language: Английский
Citations
17
Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 101, P. 101335 - 101335
Published: Jan. 1, 2025
Renal cell carcinoma (RCC) is a malignant tumor with highly heterogeneous and complex molecular mechanisms. Through systematic analysis of TCGA, COSMIC other databases, 24 mutated genes closely related to RCC were screened, including VHL, PBRM1, BAP1 SETD2, which play key roles in signaling pathway transduction, chromatin remodeling DNA repair. The PI3K/AKT/mTOR particularly important the pathogenesis RCC. Mutations such as PIK3CA, MTOR PTEN are associated metabolic abnormalities proliferation. Clinically, mTOR inhibitors VEGF-targeted drugs have shown significant efficacy personalized therapy. Abnormal regulation reprogramming, especially glycolysis glutamine pathways, provides cells continuous energy supply survival advantages, GLS1 promising results preclinical studies. This paper also explores potential immune checkpoint combination targeted drugs, well application nanotechnology drug delivery In addition, unique mechanisms revealed individualized therapeutic strategies explored for specific subtypes TFE3, TFEB rearrangement type SDHB mutant type. review summarizes common gene mutations their mechanisms, emphasizes diagnosis, treatment prognosis, looks forward prospects multi-pathway therapy, immunotherapy treatment, providing theoretical support clinical guidance new development.
Language: Английский
Citations
2
Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)
Published: Feb. 28, 2025
Direct skin-to-skin contact during intimate sexual with a human papillomavirus (HPV)-positive individual is often the cause of HPV infection. In addition, many studies have been written up to date that look at role in growth other types tumors. Not all urological cancers are associated HPV. However, penile cancer (PC) caused by HPV, especially high-risk types. HPV-16 has most frequent (68.3%), followed HPV-6 (8.1%) and HPV-18 (6.9%). An increased risk getting certain urinary like prostate, bladder, testicular, kidney also linked these infections. Additionally, may play part continuous inflammation progression different organs tissues. So, making vaccine programs available more people male sex around world could significantly lower number The critical effects on urologic (UCs), such as penile, cancer, importance vaccination seen this study.
Language: Английский
Citations
2
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: Feb. 11, 2025
Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167677 - 167677
Published: Jan. 1, 2025
Lymphedema is characterized by the swelling of extremities due to accumulation interstitial fluids. It a painful and devastating disease that increases risk infections destroys patients' quality life. Secondary lymphedema caused damage lymphatic system infections, obesity, surgery, cancer treatments. This fails be repaired leads fluid accumulation, tissue remodeling, inflammation, ultimately fibrosis. The microenvironment altered stress, immune dysfunction, changes in metabolism. Stress includes increased hypoxia oxidative stress but how this contributes progression unclear. plays critical role through T cell helper type 2 (Th2) responses infiltration macrophages into lymphedematous tissue. inflammatory cytokines released cells lead remodeling There are also metabolism with lipid oxidation, ketone body glycolysis. How these affect treatment interventions has been focus clinical trials. associated obesity system. review will illustrate microenvironmental relates obesity. In addition, we discuss new therapeutic strategies treat lymphedema. Finally, address prospects research context microenvironment.
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)
Published: May 3, 2025
Language: Английский
Citations
0
Published: March 28, 2024
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) potently attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. strongly upregulated hypoxia and/or inflammation-induced inflammatory secretion, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.
Language: Английский
Citations
2
Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5678 - 5690
Published: Oct. 1, 2024
Obesity is an important risk factor for the onset of kidney cancer, and mechanism obesity leading to occurrence development cancer has been further studied confirmed in past decade. The emergence "obesity paradox" phenomenon made correlation between prognosis survival controversial. This review summarizes association based on newly discovered evidence 10 years, order provide reference follow-up research.
Language: Английский
Citations
2
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)
Published: Nov. 9, 2024
Abstract The present review provides a comprehensive overview of the current state in vitro cancer studies, focusing on recent advancements and ongoing cell culture models analyses techniques. Cancer cells grow complex dynamic environment, interacting with various cellular components, such as stromal cells, cancer‐associated fibroblasts, immune extracellular matrix (ECM). ECM structural support unique characteristics essential for tumorigenesis. Accurately modeling this intricate tumor microenvironment precisely analyzing cell–cell cell–ECM interactions are crucial understanding progression therapeutic responses. Consequently, oncology research is advancing toward a) three‐dimensional models, b) single‐cell level analyses, c) live‐cell analyses. This aims to elucidate knowledge field, emphasizing benefits these innovative approaches offer over traditional two‐dimensional bulk endpoint measurements.
Language: Английский
Citations
2
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Dec. 4, 2024
The SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) has emerged as a critical regulator in cancer biology, modulating the stability of Hypoxia-Inducible Factor 1-alpha (HIF1α) and influencing network hypoxia-driven pathways within tumor microenvironment (TME). SMURF2 targets HIF1α for ubiquitination subsequent proteasomal degradation, disrupting hypoxic responses that promote cell survival, metabolic reprogramming, angiogenesis, resistance to therapy. Beyond its role regulation, exerts extensive control over cellular processes central progression, including chromatin remodeling, DNA damage repair, ferroptosis, stress responses. Notably, SMURF2's ability ferroptotic death through GSTP1 degradation offers an alternative pathway overcome apoptosis resistance, expanding therapeutic options refractory cancers. This review delves into multifaceted interactions between HIF1α, emphasizing how their interplay impacts adaptations like Warburg effect, immune evasion, resistance. We discuss dual functionality both suppressor and, certain contexts, oncogenic factor, underscoring potential highly versatile target. Furthermore, SMURF2-HIF1α axis presents innovative approach destabilize hypoxia-dependent pathways, sensitizing tumors chemotherapy, radiotherapy, immune-based treatments. However, complexity necessitate thorough assessment off-target effects challenges specificity, which must be addressed optimize clinical application. concludes by proposing future directions research pathway, aiming refine targeted strategies exploit this address adaptive mechanisms aggressive tumors, ultimately advancing landscape precision oncology.
Language: Английский
Citations
2