Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 659 - 659

Published: Feb. 19, 2023

Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens currently in clinical use. However, precise mechanisms DOX’s action are not fully understood. Emerging evidence points to pleiotropic anticancer activity DOX, including its contribution DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well immunomodulatory role. This review aims collect information on DOX influence anti-tumor immune response, providing a rationale behind importance modern cancer therapy.

Language: Английский

---

Berberine: A Promising Treatment for Neurodegenerative Diseases

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 20, 2022

Berberine, as a natural alkaloid compound, is characterized by diversity of pharmacological effects. In recent years, many researches focused on the role berberine in central nervous system diseases. Among them, effect neurodegenerative diseases has received widespread attention, for example Alzheimer’s disease, Parkinson’s Huntington’s and so on. Recent evidence suggests that inhibits production neuroinflammation, oxidative, endoplasmic reticulum stress. These effects can further reduce neuron damage apoptosis. Although current research made some progress, its specific mechanism still needs to be explored. This review provides an overview related mechanisms, also new ideas future berberine.

Language: Английский

---

Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1022 - 1022

Published: Jan. 19, 2023

Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which important sources of discovery tumor treatment. The combination chemotherapeutic drugs natural gradually becoming an strategy development direction In this paper, we described role in with synergizing, reducing mitigating effects related mechanisms, providing new insights future oncology research.

Language: Английский

---

Image‐guided diagnosis and treatment of glioblastoma

View, Journal Year: 2023, Volume and Issue: 4(3)

Published: Feb. 2, 2023

Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of blood–brain barrier (BBB) prevents diagnostic therapeutic drugs from penetrating working in GBM. In traditional surgical treatment, it difficult to completely distinguish boundary between surrounding normal tissue, resulting incomplete resection tumor. Therefore, diagnosis treatment GBM are very challenging. Several molecular probes nanoprobes have been reported successfully penetrate BBB, selectively target accumulate achieve situ imaging tumors, thus achieving accurate orthotopic or non‐orthotopic This paper reviews advances image‐guided design principle, application, advantages each probe enumerated detail. Finally, prospects potential challenges discussed a view further promote study application novel

Language: Английский

---

New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 175, P. 113721 - 113721

Published: March 11, 2023

Language: Английский

---

Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats

Cardiovascular Toxicology, Journal Year: 2021, Volume and Issue: 22(2), P. 152 - 166

Published: Nov. 27, 2021

Language: Английский

---

A Combined Treatment with Berberine and Andrographis Exhibits Enhanced Anti-Cancer Activity through Suppression of DNA Replication in Colorectal Cancer

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(3), P. 262 - 262

Published: Feb. 22, 2022

The high morbidity and mortality associated with colorectal cancer (CRC) are largely due to the invariable development of chemoresistance classic chemotherapies, as well intolerance their significant toxicity. Many pharmaceutical formulations screened from natural plant extracts offer safe, inexpensive, multi-target therapeutic options. In this study, we demonstrated that Berberis vulgaris L. (Berberine) Andrographis paniculata (Burm. f.) Nees (Andrographis) exerted synergistic amplified anti-cancer effects by jointly inhibiting cell viability, suppressing colony formation, inducing cycle arrest. Consistent our in-vitro findings, were also observed in subcutaneous xenograft preclinical animal models, patient-derived primary tumor organoids. To explore molecular mechanisms underlying effects, RNA sequencing was performed identify candidate pathways genes. A transcriptome analysis revealed DNA-replication-related genes, including FEN1, MCM7, PRIM1, MCM5, POLA1, MCM4, PCNA, may be responsible for enhanced anticancer these two extracts. Taken together, data powerful anti-CRC berberine provide evidence combinational targeting genes a promising new strategy option management CRC patients.

Language: Английский

---

Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases

Health Sciences Review, Journal Year: 2022, Volume and Issue: 6, P. 100071 - 100071

Published: Dec. 10, 2022

Neurodegenerative diseases (NDs) encompass a broad range of conditions characterized by progressive neuronal degeneration and death manifesting with variety signs symptoms ranging from reduced cognitive function to motor dysfunctions. NDs share number molecular pathogenic mechanism, the most frequent which is oxidative stress (OS). Currently, no ND curative, therapies offered merely control or slow illness development. As result, current therapy research has focused on developing multi-targeted therapeutic approaches. This approach also consistent natural product derivatives characteristics, such as phytochemicals. Because their antioxidant effects, alkaloids, one phytochemicals, have potential cure targeting OS mechanism. Role plant derived alkaloids (34) agents for are summarized in this review.

Language: Английский

---

Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats

Life Sciences, Journal Year: 2022, Volume and Issue: 314, P. 121317 - 121317

Published: Dec. 23, 2022

Language: Английский

---

An update on neurobiological mechanisms involved in the development of chemotherapy-induced cognitive impairment (CICI)

Toxicology Reports, Journal Year: 2023, Volume and Issue: 10, P. 544 - 553

Published: Jan. 1, 2023

Cancer is the second leading cause of death worldwide despite efforts in early diagnosis disease and advances treatment. The use drugs that exert toxic effects on tumor cells or chemotherapy one most widely used treatments against cancer. However, its low selectivity affects both healthy cancer cells. It has been reported chemotherapeutic may generate neurotoxicity induces deleterious central nervous system. In this sense, patients report decreased cognitive abilities, such as memory, learning, some executive functions after chemotherapy. This chemotherapy-induced impairment (CICI) develops during treatment persists even Here we present a review literature main neurobiological mechanisms involved CICI using Boolean formula following steps PRISMA guidelines were to perform statements searches various databases. described explain CRCI include direct indirect induce by agents. Therefore, provides general understanding possible therapeutic targets prevent it..

Language: Английский

---