IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Ionic
liquids
(ILs)
have
emerged
as
a
cutting-edge
frontier
in
the
realm
of
science
and
technology,
offering
unique
blend
tunable
physicochemical
biological
features
with
eco-friendly
characteristics.
Thus,
ILs
exhibit
broad
spectrum
applications
pharmacology,
pharmaceuticals,
medicine,
pharmaceutical
fields,
providing
solutions
to
challenges
drug
formulation
delivery.
The
focus
this
chapter
is
on
application
IL
methodologies
strategies
resolve
critical
issues
within
field,
such
polymorphism,
low
solubility,
stability,
bioavailability,
which
are
problems
solid-state
pharmaceuticals.
innovative
use
carriers
for
active
ingredients
(APIs)
presents
highly
promising
avenue
addressing
these
challenges.
In
conclusion,
detailed
utilization
applications,
strategic
design
liquid
salts
has
potential
revolutionize
way
we
address
development,
manufacturing,
developing
biocompatible
ILs.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(38), P. 14288 - 14295
Published: Aug. 20, 2024
Direct
air
capture
of
carbon
dioxide
(CO2)
is
crucial
for
lowering
the
concentration
atmospheric
CO2
and
preventing
global
climate
change.
Nonetheless,
a
significant
obstacle
remains
in
advancing
effective
separation
techniques.
The
tunable
chemical
structures,
high
thermal
stability,
nominal
vapor
pressure
ionic
liquids
(ILs)
make
them
attractive
solvents
absorption.
Deep
eutectic
(DESs)
are
broadly
recognized
as
new
class
IL
analogs
because
their
numerous
similarities
features
to
ILs.
In
this
work,
at
first,
we
have
synthesized
alanine-
lysine-based
ILs,
tetraethylammonium
alaninate
([N2222][Ala])
lysinate
([N2222][Lys]),
utilized
prepare
DESs
by
mixing
ILs
hydrogen-bond
acceptor
(HBA)
ethylene
glycol
(EG)
donor
(HBD).
Those
less
viscous
higher
absorption
efficiency
than
constituent
vapor–liquid
equilibrium
(VLE)
experiment
shows
that
pure
capacity
[N2222][Lys]-based
DES
considerably
[N2222][Ala]
containing
DES.
We
employed
those
amino
acid-functionalized
IL-based
from
open
very
first
time,
best
our
knowledge.
direct
highly
efficient
capturing
air.
saturated
uptake
1.06
mol/mol,
whereas
value
0.47
mol/mol.
reversible
toward
desorption
up
several
cycles.
believe
systems
will
be
superior
eliminating
polluted
Advances in Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
325, P. 103120 - 103120
Published: Feb. 28, 2024
The
last
couple
of
decades
have
seen
an
explosion
novel
colloidal
drug
delivery
systems,
which
been
demonstrated
to
increase
efficacy,
reduce
side-effects,
and
provide
various
other
advantages
for
both
small-molecule
biomacromolecular
drugs.
interactions
systems
with
biomembranes
are
increasingly
recognized
play
a
key
role
efficient
eradication
pathogens
cancer
cells,
as
well
intracellular
protein
nucleic
acid
In
parallel,
there
has
broadening
methodologies
investigating
such
systems.
For
example,
advanced
microscopy,
mass-spectroscopic
"omic"-techniques,
small-angle
X-ray
neutron
scattering
techniques,
only
few
years
ago
were
largely
restricted
rather
specialized
areas
within
basic
research,
currently
seeing
increased
interest
from
researchers
wide
application
fields.
the
present
discussion,
focus
is
placed
on
use
reflectometry
investigate
membrane
Although
technique
still
less
extensively
employed
investigations
than,
e.g.,
scattering,
studies
may
mechanistic
information
regarding
binding,
re-modelling,
translocation,
permeation,
importance
efficacy
toxicity
antimicrobial,
cancer,
therapeutics.
following,
examples
this
discussed
gaps/opportunities
in
research
field
identified.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(11), P. 2265 - 2265
Published: Oct. 23, 2022
In
recent
years,
deep
eutectic
systems
(DES)
emerged
as
novel
vehicles
for
facilitating
the
transdermal
delivery
of
various
drugs,
including
polysaccharides,
proteins,
insulin,
vaccine,
nanoparticles,
and
herb
extracts.
The
objective
this
study
is
to
conduct
a
comprehensive
review
application
DES
drug
delivery,
based
on
previous
work
reported
references.
Following
brief
overview,
roles
in
TDDS,
modes
action,
well
structure-activity
relationship
are
discussed.
Particularly,
skin
permeation
active
macromolecules
rigid
which
defining
characteristics
DES,
extensively
provide
understanding
current
investigation
development
DES-based
systems,
framework
construction
DES-TDDS
future.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(22), P. 9001 - 9019
Published: Jan. 1, 2023
Polymer
chains
endow
PILs
with
unique
aggregation
structures
and
morphologies
that
are
inaccessible
to
monomeric
ILs,
making
them
a
sustainable
material
allowing
be
used
in
various
applications.
RSC Sustainability,
Journal Year:
2024,
Volume and Issue:
2(6), P. 1809 - 1818
Published: Jan. 1, 2024
Phenolic
polymeric
deep
eutectic
solvents
form
coloured
complexes
with
iron
surfaces
which
can
be
used
as
protection
coatings
for
corrosion
control
of
mild
steel.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(10), P. 4168 - 4176
Published: Feb. 27, 2023
Extraction
of
active
compounds
from
natural
materials
is
commonly
used
to
produce
a
diverse
range
ingredients,
nutrients,
drugs,
flavors,
and
fragrances.
While
solvent-based
approaches
are
standard
for
these
extraction
procedures,
large
solvent
volumes,
greenhouse
gas
emission
(due
atmospheric
release
volatile
organic
compounds),
energy
requirements
significant
issues.
Here,
we
describe
novel
process
wherein
mechanical
action
applied
solid-state
mixture
comprising
quaternary
ammonium
salt
biological
material
containing
molecules
form
deep
eutectic
mixture.
It
first
shown
that
mixtures
can
be
formed
wide
naturally
occurring
compounds.
Selective
products
then
demonstrated
using
rosemary
leaves
with
three
different
salts.
The
purified
by
liquid/liquid
an
oily
phase
concentrate
the
constituents
in
phase.
resulting
extracts
exhibit
high
antioxidant
activities,
which
were
measured
conjugated
autoxidizable
triene
(CAT)
oxygen
radical
absorbance
capacity
(ORAC)
assays.
