Body composition differences in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons

Karen D. Bernal-Contreras,

Montserrat Berrospe-Alfaro,

Regina López de Cárdenas-Rojo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 5, 2024

Background Although body composition (BC) has been associated with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), there is little evidence of differences in BC patients MASLD regarding mass index (BMI). The aim this study was to determine terms BMI and metabolic comorbidities MASLD. Materials methods It a cross-sectional who attended the check-up unit. steatosis evaluated by controlled attenuation parameter, were classified into five groups according BMI, presence MASLD, characteristics: <25 kg/m 2 non-MASLD; -MASLD; Overweight-MASLD; Metabolically Healthy Obese (MHO)-MASLD; Unhealthy (MUO)-MASLD. assessed bioelectrical impedance Bioimpedance Vectorial Analysis (BIVA) carried out. Differences analyzed One-Way ANOVA test. Univariate multivariate analyses performed for factors abnormal BC. Results A total 316 included. 59% ( n = 189) male, mean age 49 ± 10 years. Fat% significantly higher not different between -MASLD Overweight-MASLD groups. Skeletal muscle (SMM) lower obesity respect overweight normal weight p < 0.05); however, no observed post-hoc analysis. Extracellular Water/Intracellular Water ratio MHO-MASLD group MUO-MASLD compared non-MASLD group. Abnormal Waist Circumference (WC) liver independent Conclusion varies increase; changes could be explained loss SMM necessarily abnormalities. High WC are altered

Language: Английский

The interplay of factors in metabolic syndrome: understanding its roots and complexity DOI Creative Commons
Md. Sharifull Islam, Ping Wei, Md Suzauddula

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 27, 2024

Abstract Metabolic syndrome (MetS) is an indicator and diverse endocrine that combines different metabolic defects with clinical, physiological, biochemical, factors. Obesity, visceral adiposity abdominal obesity, dyslipidemia, insulin resistance (IR), elevated blood pressure, endothelial dysfunction, acute or chronic inflammation are the risk factors associated MetS. Abdominal a hallmark of MetS, highlights dysfunctional fat tissue increased for cardiovascular disease diabetes. Insulin, vital peptide hormone, regulates glucose metabolism throughout body. When cells become resistant to insulin’s effects, it disrupts various molecular pathways, leading IR. This condition linked range disorders, including diabetes, fatty liver disease, polycystic ovary syndrome. Atherogenic dyslipidemia characterized by three key factors: high levels small, low-dense lipoprotein (LDL) particles triglycerides, alongside low high-density (HDL), “good” cholesterol. Such combination major player in where IR driving force. contributes significantly development atherosclerosis, which can lead disease. On top that, genetic alteration lifestyle such as diet exercise influence complexity progression To enhance our understanding consciousness, essential understand fundamental pathogenesis review current advancements MetS research involvement gut microbiome, epigenetic regulation, metabolomic profiling early detection Mets. In addition, this emphasized epidemiology factors, their preventive measures. The goal effort deepen encourage further develop effective strategies preventing managing complex diseases.

Language: Английский

Citations

5
Zinc finger 259 gene polymorphisms in Egyptian patients with metabolic syndrome and its association with dyslipidemia DOI
Doha El‐Sayed Ellakwa,

Khaleda S Amr,

Moushira Zaki

et al.

Irish Journal of Medical Science (1971 -), Journal Year: 2024, Volume and Issue: 193(5), P. 2313 - 2323

Published: July 10, 2024

Language: Английский

Citations

4
Relationship between dietary flavan-3-ols intake and mortality in metabolic syndrome population; a large cohort study DOI Creative Commons
Wanjia Zhang, Qian Zhou, Weiqing Yang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

Metabolic syndrome (MetS) is a global health concern linked to increased mortality. Diets rich in plant-derived compounds, such as polyphenols, have shown potential benefits for MetS. Among these, flavan-3-ols, class of commonly occurring polyphenolic are known their antioxidant and anti-inflammatory properties. Therefore, we hypothesize that flavan-3-ols intake negatively associated with mortality risk MetS population. This study analyzed NHANES data (2007-2008, 2009-2010, 2017-2018). Flavan-3-ol monomer were obtained from the USDA Flavonoid FNDDS databases. Associations assessed using Cox regression, survival differences compared Kaplan-Meier curves, non-linear trends examined restricted cubic splines. Subgroup analyses conducted explore effect modifications. Over median follow-up period 114 months, 1,856 participants survived, while 329 deaths recorded. In Model 3, highest tertile (T3) flavan-3-ol exhibited 33% lower all-cause those lowest (T1) (HR = 0.67, 95%CI: 0.49-0.92). For monomers, hazard ratios ranged 0.55 higher levels epigallocatechin 0.71 gallocatechin. curves indicated significant status across dietary groups. However, no association was found between cardiovascular risk. Additionally, spline (RCS) analysis did not reveal any relationship, interaction effects observed subgroup analysis. Higher

Language: Английский

Citations

0
Association between fat-soluble vitamins and metabolic syndromes in US adults: a cross-section study from NHANES database DOI Creative Commons

Muxi Li,

Shan Jiang,

Chenxuan Dong

et al.

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 6, 2024

Language: Английский

Citations

2
Near‐infrared reactance spectroscopy‐derived visceral adipose tissue for the assessment of metabolic syndrome in a multi‐ethnic sample of young adults DOI
Austin J. Graybeal, Caleb F. Brandner,

Havens L. Wise

et al.

American Journal of Human Biology, Journal Year: 2024, Volume and Issue: 36(10)

Published: July 22, 2024

Abstract Objectives Visceral adipose tissue (VAT) is highly associated with metabolic syndrome (MetS), which rapidly increasing in young adults. However, accessible VAT measurement methods are limited, restricting the use of early detection. This cross‐sectional study sought to determine if near‐infrared reactance spectroscopy (NIRS)‐derived (VAT NIRS ) was MetS a multi‐ethnic sample Methods A total 107 male and female (F:62, M:45) participants (age: 23.0 ± 4.3y; BMI: 27.1 6.6 kg/m 2 completed measurements fasting blood pressure, glucose (FBG), lipids, anthropometric assessments including waist circumference . severity (MetS index calculated from aforementioned risk factors using sex race‐specific equations. Results higher with, at for, compared those lower risks (all p < .001). positively for all groups showed positive associations systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), LDL‐C LDL‐C‐related biomarkers, FBG; negative HDL‐C HDL‐C‐to‐total cholesterol ratio .050). Associations between females, biomarkers males, were nonsignificant > DBP African–American participants, SBP White resulting MAP both Conclusions individual adults; providing noninvasive, cost‐effective, portable, method that may assist detection other cardiometabolic abnormalities.

Language: Английский

Citations

1
Body composition differences in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons

Karen D. Bernal-Contreras,

Montserrat Berrospe-Alfaro,

Regina López de Cárdenas-Rojo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 5, 2024

Background Although body composition (BC) has been associated with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), there is little evidence of differences in BC patients MASLD regarding mass index (BMI). The aim this study was to determine terms BMI and metabolic comorbidities MASLD. Materials methods It a cross-sectional who attended the check-up unit. steatosis evaluated by controlled attenuation parameter, were classified into five groups according BMI, presence MASLD, characteristics: &lt;25 kg/m 2 non-MASLD; -MASLD; Overweight-MASLD; Metabolically Healthy Obese (MHO)-MASLD; Unhealthy (MUO)-MASLD. assessed bioelectrical impedance Bioimpedance Vectorial Analysis (BIVA) carried out. Differences analyzed One-Way ANOVA test. Univariate multivariate analyses performed for factors abnormal BC. Results A total 316 included. 59% ( n = 189) male, mean age 49 ± 10 years. Fat% significantly higher not different between -MASLD Overweight-MASLD groups. Skeletal muscle (SMM) lower obesity respect overweight normal weight p &lt; 0.05); however, no observed post-hoc analysis. Extracellular Water/Intracellular Water ratio MHO-MASLD group MUO-MASLD compared non-MASLD group. Abnormal Waist Circumference (WC) liver independent Conclusion varies increase; changes could be explained loss SMM necessarily abnormalities. High WC are altered

Language: Английский

Citations

1