Dechlorination
of
chloropyridines
can
eliminate
their
detrimental
environmental
effects.
However,
traditional
dechlorination
technology
cannot
efficiently
break
the
C–Cl
bond
chloropyridines,
which
is
restricted
by
uncontrollable
nonselective
species.
Hence,
we
propose
carbonate
species-activated
hydrogen
peroxide
(carbonate
species/H2O2)
process
wherein
selective
oxidant
(peroxymonocarbonate
ion,
HCO4–)
and
reductant
(hydroperoxide
anion,
HO2–)
controllably
coexist
manipulation
reaction
pH.
Taking
2-chloropyridine
(Cl–Py)
as
an
example,
HCO4–
first
induces
Cl–Py
into
pyridine
N-oxidation
intermediates,
then
suffer
from
nucleophilic
HO2–.
The
obtained
efficiencies
in
species/H2O2
(32.5–84.5%)
based
on
cooperation
HO2–
are
significantly
higher
than
those
HO2–-mediated
sodium
hydroxide/hydrogen
(0–43.8%).
Theoretical
calculations
confirm
that
effectively
lower
energy
barrier
process.
Moreover,
exhibits
superior
anti-interference
performance
low
electric
consumption.
Furthermore,
completely
detoxified
via
More
importantly,
applicable
for
efficient
dehalogenation
halogenated
pyridines
pyrazines.
This
work
offers
a
simple
useful
strategy
to
enhance
efficiency
organics
sheds
new
insights
application
practical
remediation.
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
13(10), P. 6983 - 6993
Published: May 8, 2023
A
simple
and
general
method
for
anti-selective
hydrosulfonylation
of
unactivated
alkynes
with
sulfonyl
chlorides
in
the
presence
a
catalytic
amount
phenanthroline-based
Lewis
base
(Me3Si)3SiH
as
hydrogen
atom
donor
has
been
developed.
The
protocol
proceeds
efficiently
under
mild
metal-free
conditions,
delivering
diverse
set
(Z)-vinyl
sulfones
high
stereoselectivity.
Additionally,
displays
excellent
functional-group
compatibility
can
be
applied
to
late-stage
modifications
complex
drugs
their
derivatives.
Experimental
density
functional
theory
studies
unveiled
that
key
transformation's
success
is
employment
base,
which
interacts
form
halogen-bond
accelerates
cleavage
S–Cl
bonds
irradiation
visible
light.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
26(1), P. 411 - 415
Published: Dec. 26, 2023
We
report
a
strategic
exploitation
of
trifluoromethyl
thianthrenium
triflate
(TT-CF3+OTf–)
as
both
electromediator
and
CF3
radical
precursors
for
paired
electrolysis.
Enabled
by
this
strategy,
the
three-component
trifluoromethylheteroaromatization
alkenes
alkynes
was
realized.
The
superiority
TT-CF3+OTf–
to
other
electrophilic
reagents
is
attributed
cathodic
generation
thianthrene
(TT)
mediator,
which
shifts
heterogeneous
oxidation
interest
homogeneous
one.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(12), P. 4656 - 4661
Published: Jan. 1, 2023
An
electrochemical-enabled
three-component
cascaded
cyclization
of
enaminones
with
potassium
thiocyanate
and
alcohols
to
access
2-alkoxythiazoles
has
been
developed
under
external
oxidant-free
conditions.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(13), P. 1583 - 1588
Published: Feb. 14, 2023
Comprehensive
Summary
A
new
electrochemical
strategy
for
the
atom
transfer
radical
addition
(ATRA)
of
polychloroalkanes
across
olefins
has
been
realized
by
synergism
paired
electrolysis
and
halogen
bonding
activation.
Notably,
readily
accessible
4,4‐di‐
tert
‐butyl
bipyridine
(dtbpy),
acting
as
a
acceptor,
shifted
reduction
potential
C—Cl
bonds
positively
110
mV.
The
decreased
operating
leads
to
wide
substrate
scope
excellent
functional
group
compatibility.
diverse
array
terminal
internal
alkenes
such
(hetero)aryl
olefins,
unactive
aliphatic
natural
products
drugs‐derived
were
well
compatible.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(8), P. 5434 - 5441
Published: April 6, 2024
A
mild
method
for
the
C–H/S–H
coupling
of
pyrazol-5-amines
and
thiophenols
was
developed
via
electrochemistry,
giving
diverse
amino
pyrazole
thioether
derivatives
in
37–98%
yields.
This
electrochemical
reaction
is
sustainable
an
atom-efficient
approach
with
good
functional
group
tolerance
scalability
by
avoiding
metal
external
chemical
oxidants.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(11), P. 1782 - 1787
Published: May 11, 2023
Abstract
An
electrochemical
method
for
the
C(
sp
2
)−H
thiocyanation
of
pyrazol‐5‐amines
and
enamines
were
developed
in
an
undivided
cell.
A
variety
thiocyanated
pyrazol‐5‐amine
enamine
derivatives
accessed
36–91%
yields,
employing
thiocyanate
salts
as
electrolyte
thiocyanating
reagent.
Moreover,
this
protocol
can
be
extended
to
synthesis
various
iodinated
brominated
51–95%
yields.
This
does
not
require
a
metal
or
external
chemical
oxidants
tolerates
unprotected
amino
groups.
Catalysis Science & Technology,
Journal Year:
2024,
Volume and Issue:
14(4), P. 1037 - 1042
Published: Jan. 1, 2024
We
report
an
electrophotoredox
cerium-catalyzed
LMCT
strategy
to
incorporate
carboxylic
acids
into
radical
cyclization
cascades.
This
protocol
provides
a
solution
address
the
challenges
in
alkylated
benzimidazo-fused
isoquinolinone
synthesis.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(9), P. 6106 - 6116
Published: April 18, 2024
An
electrochemical
oxidative
cross-coupling
strategy
for
the
synthesis
of
N-sulfenylsulfoximines
from
sulfoximines
and
thiols
was
accomplished,
giving
diverse
in
moderate
to
good
yields.
Moreover,
this
can
be
extended
construct
N–P
bond
N-phosphinylated
sulfoximines.
With
electrons
as
reagents,
dehydrogenation
reaction
proceeds
smoothly
absence
traditional
redox
reagents.
