Intestinal Barrier Dysfunction and Gut Microbiota in Non-Alcoholic Fatty Liver Disease: Assessment, Mechanisms, and Therapeutic Considerations

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 243 - 243

Published: April 6, 2024

Non-alcoholic fatty liver disease (NAFLD) is a type of metabolic stress injury closely related to insulin resistance (IR) and genetic susceptibility without alcohol consumption, which encompasses spectrum disorders ranging from simple hepatic lipid accumulation, known as steatosis, the more severe form steatohepatitis (NASH). NASH can progress cirrhosis hepatocellular carcinoma (HCC), posing significant health risks. As multisystem disease, NAFLD associated with systemic resistance, central obesity, disorders, contribute its pathogenesis development extrahepatic complications, such cardiovascular (CVD), 2 diabetes mellitus, chronic kidney certain cancers. Recent evidence highlights indispensable roles intestinal barrier dysfunction gut microbiota in onset progression NAFLD/NASH. This review provides comprehensive insight into role NAFLD, including function assessment, inflammatory factors, TLR4 signaling, gut–liver axis. Finally, we conclude discussion on potential therapeutic strategies targeting permeability individuals NAFLD/NASH, interventions medications/probiotics, fecal transplantation (FMT), modifications lifestyle, exercise diet.

Language: Английский

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Extracellular polysaccharides from Sporidiobolus pararoseus alleviates rheumatoid through ameliorating gut barrier function and gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129436 - 129436

Published: Jan. 21, 2024

Language: Английский

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Exosomal miR‐122, miR‐128, miR‐200, miR‐298, and miR‐342 as novel diagnostic biomarkers in NAFL/NASH: Impact of LPS/TLR‐4/FoxO3 pathway

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(4)

Published: Jan. 22, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is a common disorder affecting quarter of the global residents. Progression NAFL into nonalcoholic steatohepatitis (NASH) may cause cirrhosis, cancer, and failure. Gut microbiota imbalance causes microbial components translocation circulation, triggering inflammation NASH‐related fibrosis. MicroRNAs (miRNAs) regulate gene expression via repressing target genes. Exosomal miRNAs are diagnostic prognostic biomarkers for NASH damage. Our work investigated role gut in NAFLD pathogenesis lipopolysaccharide/toll‐like receptor 4/Forkhead box protein O3 (LPS/TLR‐4/FoxO3) pathway certain as noninvasive or its development to NASH. miRNA levels were measured using quantitative reverse transcription polymerase chain reaction (qRT‐PCR) 50 patients, normal controls. Plasma LPS, TLR‐4, adiponectin, peroxisome proliferator‐activated γ (PPAR‐γ), FoxO3 concentrations enzyme‐linked immunosorbent assay (ELISA). In miR‐122, miR‐128, FoxO3, PPAR‐γ upregulated while miR‐200, miR‐298, miR‐342, adiponectin downregulated compared with control. The examined might distinguish patients from control receiver operating characteristic analysis. study first examine these NAFLD. findings imply that potentially promising early diagnosis progression. Understanding LPS/TLR‐4/FoxO3 involvement NAFL/NASH aid management.

Language: Английский

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Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2841 - 2841

Published: Feb. 29, 2024

Metabolic syndrome (MetS) is a combination of metabolic disorders that concurrently act as factors promoting systemic pathologies such atherosclerosis or diabetes mellitus. It now believed to encompass six main interacting conditions: visceral fat, imbalance lipids (dyslipidemia), hypertension, insulin resistance (with without impairing both glucose tolerance and fasting blood sugar), inflammation. In the last 10 years, there has been progressive interest through scientific research investigations conducted in field metabolomics, confirming trend evaluate role metabolome, particularly intestinal one. The microbiota (IM) crucial due diversity microorganisms their abundance. Consequently, IM dysbiosis its derivate toxic metabolites have correlated with MetS. By intervening these two (dysbiosis consequently metabolome), we can potentially prevent slow down clinical effects MetS process. This, turn, may mitigate dysregulations axes, lung axis, thereby alleviating negative impact on respiratory pathology, chronic obstructive pulmonary disease. However, biomolecular mechanisms which influences host’s metabolism via metabolome normal pathological conditions are still unclear. this study, seek provide description knowledge date influence it. Furthermore, analyze interactions between functions pathophysiology major diseases local metabolome’s relate endotoxemia.

Language: Английский

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Chlorogenic acid ameliorated non-alcoholic steatohepatitis via alleviating hepatic inflammation initiated by LPS/TLR4/MyD88 signaling pathway

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 376, P. 110461 - 110461

Published: March 23, 2023

Language: Английский

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