Effects of dietary components on intestinal permeability in health and disease

AJP Gastrointestinal and Liver Physiology, Journal Year: 2020, Volume and Issue: 319(5), P. G589 - G608

Published: Sept. 9, 2020

Altered intestinal permeability plays a role in many pathological conditions. Intestinal is component of the barrier. This barrier dynamic interface between body and food pathogens that enter gastrointestinal tract. Therefore, dietary components can directly affect this interface, metabolites produced by host enzymes or gut microbiota act as signaling molecules exert direct effects on Our aim was to examine diet health disease states. Herein, we conducted an in-depth PubMed search based specific key words (diet, permeability, barrier, health, disease, disorder), well cross references from those articles. The normal consists multiple lumen, epithelial cell layer lamina propria. Diverse methods are available measure permeability. We focus predominantly human vivo studies, literature reviewed identify factors decrease (e.g., emulsifiers, surfactants, alcohol) increase fiber, short-chain fatty acids, glutamine, vitamin D) integrity. Effects these items states, such metabolic syndrome, liver colitis documented examples dysfunction multifactorial diseases. function associated with precise mechanisms some instances; further research has potential clarify interventions treating diverse pathologic

Language: Английский

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Probiotics as a biological detoxification tool of food chemical contamination: A review

Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 153, P. 112306 - 112306

Published: May 28, 2021

Nowadays, people are exposed to diverse environmental and chemical pollutants produced by industry agriculture. Food contaminations such as persistent organic (POPs), heavy metals, mycotoxins a serious concern for global food safety with economic public health implications especially in the newly industrialized countries (NIC). Mounting evidence indicates that chronic exposure contaminants referred xenobiotics exert negative effect on human inflammation, oxidative stress, intestinal disorders linked perturbation of composition metabolic profile gut microflora. Although physicochemical technologies decontamination utilized many cases but require adequate conditions which often not feasible be met industrial sectors. At present, one promising approach reduce risk related presence foodstuffs is biological detoxification done probiotic strains their enzymes. Many studies confirmed probiotics an effective, feasible, inexpensive tool preventing xenobiotic-induced dysbiosis alleviating toxicity. This review aims summarize current knowledge direct mechanisms can influence xenobiotics. Moreover, probiotic-xenobiotic interactions microbiota host response were also discussed.

Language: Английский

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Probiotic Consortia and Their Metabolites Ameliorate the Symptoms of Inflammatory Bowel Diseases in a Colitis Mouse Model

Microbiology Spectrum, Journal Year: 2022, Volume and Issue: 10(4)

Published: June 22, 2022

Inflammatory bowel disease (IBD) has become a global public health problem. Although the pathogenesis of is unknown, potential association between gut microbiota and inflammatory signatures been established. Probiotics, especially Lactobacillus or Bifidobacterium, are orally taken as food supplements microbial drugs by patients with IBD gastrointestinal disorders due to their safety, efficacy, power restore microenvironment. In current study, we investigated comprehensive effects probiotic bacterial consortia consisting reuteri, gasseri, acidophilus (Lactobacillus spp.), Bifidobacterium lactis (Bifidobacterium spp.) metabolites in dextran sodium sulfate (DSS)-induced colitis mouse model. Our data demonstrate that not only ameliorate phenotype but also composition structure microbiota. Moreover, effect better than any single strain. The results mixed fermentation capable ameliorating symptoms inflammation. However, administration effective respect phenotypic characteristics, such body weight, activity index (DAI), histological score. addition, led changes intestinal flora composition. summary, could exert protective roles DSS-induced model reducing inflammation regulating dysbiosis. These findings from study provide support for development probiotic-based products an alternative therapeutic strategy IBD. IMPORTANCE chronic nonspecific disease. characterized wide range lesions, often involving entire colon, mainly ulcers erosions colonic mucosa. present efficacy probiotics on recovery restoration microecology. We have superior inhibiting accelerating compared observed control group groups administered utilization approach treat

Language: Английский

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FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 11, 2023

Abstract Colonocyte metabolism shapes the microbiome. Metabolites are main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty its role in colorectal cancer (CRC) remains unexplored. In this study, we show that AA feeding promotes tumor growth AOM/DSS intestinal specific Apc −/− mice via modulating microecology increased gram-negative bacteria. Delta-5 desaturase (FADS1), a rate-limiting enzyme, upregulated CRC effectively mediates synthesis. Functionally, FADS1 regulates high microenvironment-induced enriched microbes. Elimination microbe abolishes effect. Mechanistically, microbes activate TLR4/MYD88 pathway cells contributes FADS1-AA axis to metabolize prostaglandin E2 (PGE2). Cumulatively, report potential cancer-promoting mechanism converts raising synthesized PGE2 gram-negative.

Language: Английский

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The role of probiotics in vannamei shrimp aquaculture performance – A review

Veterinary World, Journal Year: 2023, Volume and Issue: unknown, P. 638 - 649

Published: March 1, 2023

Vannamei shrimp (Litopenaeus vannamei) is an important food commodity of economic benefit due to its high price, low susceptibility disease, and popularity for consumption. These advantages have led many farmers cultivate vannamei shrimp. Efforts are underway improve the aquaculture performance this species, including use probiotics, which non-pathogenic bacteria that aid in digestion help fight disease. Probiotics usually obtained from intestines or culture environment. They low-cost, non-pathogenic, largely non-toxic source antibiotics able synthesize various metabolites antibacterial functions applications. Research on probiotic has primarily been focused increasing production. Bacterial such as Lactobacillus Nitrobacter, can be administered orally, by injection, a supplement water. survival rate, water quality, immunity, disease resistance through space competition with disease-causing bacteria, Vibrio spp. An increased number suppresses growth presence pathogenic lowers susceptibility. In addition, also breaking down complex compounds into simpler substances body absorb more easily. This mechanism improves terms weight, length, feed conversion ratio. review aimed provide information regarding contribution production aquaculture.

Language: Английский

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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(4), P. 1671 - 1704

Published: March 7, 2023

Dysfunction of gut barrier is known as "leaky gut" or increased intestinal permeability. Numerous recent scientific evidences showed the association between dysfunction and multiple gastrointestinal tract (GI) non-GI diseases. Research also demonstrated that food plays a crucial role to cause remedy related We reviewed articles from electronic databases, mainly PubMed. The data were based on animal models, cell human research in vivo vitro models. In this comprehensive review, our aim focused relationship dietary factors, permeability dysfunction, This review synthesizes currently available literature discussed three parts: (a) mechanism function, (b) supplements may promote health, medication alter (c) table organizes synthesized information by general mechanisms for diseases leaky gut/intestinal associated influences. With future research, intervention could be new target individualized disease prevention management.

Language: Английский

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Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(5), P. 1553 - 1565

Published: Feb. 29, 2024

Language: Английский

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Current Updates on Limosilactobacillus reuteri: Brief History, Health Benefits, Antimicrobial Properties, and Challenging Applications in Dairy Products

Dairy, Journal Year: 2025, Volume and Issue: 6(2), P. 11 - 11

Published: Feb. 21, 2025

This study aims to clarify the use of Limosilactobaillus reuteri (Lmb. reuteri) in dairy products, emphasizing its main characteristics and limitations through a comprehensive literature review. Lmb. reuteri, previously classified as Lactobacillus is lactic acid bacterium (LAB) generally present gastrointestinal tracts humans other animals, such sheep, chickens, rodents. was reclassified part genus Limosilactobacillus April 2020, reflecting advancements biomolecular research that identified distinct metabolic biochemical among strains. species an important producer reuterin, antimicrobial compound facilitated glycerol fermentation via specific enzymatic pathways. In addition, selected strains can be considered probiotic bacteria with numerous health benefits lead well-being improvements. It consistently related improvements gut health, immune function enhancement, cholesterol reduction. Furthermore, application products has gained prominence increasingly reported due technological sensory benefits. Despite challenges incorporation into matrix, largely need supplement these it already demonstrated significant effects on several products’ technological, sensory, quality characteristics. Future should address like strain-specific efficacy regulatory hurdles for foods.

Language: Английский

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Latest developments in food-grade delivery systems for probiotics: A systematic review

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 63(20), P. 4371 - 4388

Published: Nov. 8, 2021

Tremendous progress in the inseparable relationships between probiotics and human health has enabled advances probiotic functional foods. To ensure vitality of sensitive against multiple harsh conditions, rising food-grade delivery systems for have been developed. This review gives a summary recently reported vehicles probiotics, analyzes their respective merits drawbacks makes comparisons among them. Subsequently, applications future prospects are discussed. According to types encapsulating can be classified into "silkworm cocoons" "spider webs", which put forward this paper. The former, surrounds inner with outer protective layers, includes particles, emulsions, beads, hybrid electrospun nanofibers microcapsules. While hydrogels bigels belong latter, protects aid network structures. include preferable viability stability co-delivery systems, targeted gut release strains, more scientific experimental verification diversified food products, will enlighten further studies on delivering health. Taken together, are-or soon be-in field science, under development.

Language: Английский

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Probiotic and Antifungal Attributes of Levilactobacillus brevis MYSN105, Isolated From an Indian Traditional Fermented Food Pozha

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: July 5, 2021

The use of probiotics and antifungal capabilities the lactic acid bacteria (LAB) isolated from different niches is a strategy to prepare functional cultures biopreservatives for food/feed industries. In present study, LAB strains an Indian traditional fermented food, Pozha, were evaluated their probiotic properties biocontrol potential. A total 20 isolates selected Pozha samples collected aseptically screened antagonistic activity against Fusarium verticillioides . Among bioactive isolates, Lacticaseibacillus brevis MYSN105 showed highest in vitro , causing some morphological alterations such as damaged mycelia deformed conidia. Cell-free supernatant (CFS) L. at 16% concentration effectively reduced mycelial biomass 0.369 g compared 1.938 control. Likewise, conidial germination was inhibited 20.12%, seed treatment using CFS induced reduction spore count 4.1 × 10 6 spores/ml 1.1 9 untreated seeds. internal transcribed spacer (ITS) copy number F. decreased 5.73 7 9.026 by treatment, respectively, 8.94 high tolerance gastrointestinal conditions exhibited adhesive abilities intestinal epithelial cell lines. comparative genome analysis demonstrated specific secondary metabolite region coding bacteriocin T3PKS (type III polyketide synthase) possibly related survival antimicrobial gut environment. Our results suggest that has promising features could be potentially used developing biological control formulations minimize contamination improve food safety measures.

Language: Английский

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