The Impact of Long-Term Clinoptilolite Administration on the Concentration Profile of Metals in Rodent Organisms DOI Creative Commons
Ivan Dolanc, Lejla Ferhatović Hamzić, Tatjana Orct

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(2), P. 193 - 193

Published: Jan. 26, 2023

Heavy metals are dangerous systemic toxicants that can induce multiple organ damage, primarily by inducing oxidative stress and mitochondrial damage. Clinoptilolite is a highly porous natural mineral with magnificent capacity to eliminate from living organisms, mainly ion-exchange adsorption, thus providing detoxifying, antioxidant anti-inflammatory medicinal effects. The in vivo efficiency safety of the oral administration clinoptilolite its activated forms, tribomechanically zeolite (TMAZ) Panaceo-Micro-Activated (PMA) zeolite, as well impact on metallic biodistribution, was examined healthy female rats. Concentration profiles Al, As, Cd, Co, Pb, Ni Sr were measured rat blood, serum, femur, liver, kidney, small large intestine, brain using inductively coupled plasma mass spectrometry (ICP-MS) after 12-week period. Our results point beneficial effect materials concentration profile rats supplemented corresponding materials, TMAZ PMA zeolite. observed decrease intestine three months intake occurred concomitantly their most likely transient release into bloodstream (serum) indicative detoxification process.

Language: Английский

Role of Lactic Acid Bacteria in Food Preservation and Safety DOI Creative Commons
Agnieszka Zapaśnik, Barbara Sokołowska, Marcin Bryła

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(9), P. 1283 - 1283

Published: April 28, 2022

Fermentation of various food stuffs by lactic acid bacteria is one the oldest forms biopreservation. Bacterial antagonism has been recognized for over a century, but in recent years, this phenomenon received more scientific attention, particularly use strains (LAB). Certain LAB demonstrated antimicrobial activity against foodborne pathogens, including bacteria, yeast and filamentous fungi. Furthermore, many authors proved that have ability to neutralize mycotoxin produced last group. Antimicrobial mainly based on production metabolites such as acid, organic acids, hydroperoxide bacteriocins. In addition, some research suggests other mechanisms pathogens well their toxic metabolites. These properties are very important because future possibility exchange chemical physical methods preservation with biological method Biopreservation defined extension shelf life increase safety controlled microorganisms or This may determine alternative usage preservatives. study, possibilities provided. Our aim yield knowledge about fermentation pathogenic microorganisms. we would like introduce actual information health aspects associated consumption fermented products, probiotics.

Language: Английский

Citations

180
Probiotic Yeast Saccharomyces: Back to Nature to Improve Human Health DOI Creative Commons
Rameesha Abid, Hassan Waseem, Jafar Ali

et al.

Journal of Fungi, Journal Year: 2022, Volume and Issue: 8(5), P. 444 - 444

Published: April 24, 2022

Saccharomyces cerevisiae var. boulardii is best known for its treatment efficacy against different gastrointestinal diseases. This probiotic yeast can significantly protect the normal microbiota of human gut and inhibit pathogenicity diarrheal infections. Several clinical investigations have declared S. a biotherapeutic agent due to antibacterial, antiviral, anti-carcinogenic, antioxidant, anti-inflammatory immune-modulatory properties. Oral or intramuscular administration remarkably induce health-promoting effects in host body. Different intrinsic extrinsic factors are responsible acute chronic gut-associated review will discuss beneficial prevention metabolic diseases highlight some health-promising article provide fundamental insights new avenues fields biotherapeutics, antimicrobial resistance one health.

Language: Английский

Citations

89
Engineered Living Materials for Advanced Diseases Therapy DOI Open Access
Dong Xue, Wei Wu, Pei Pan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

Citations

53
Toxicology Effects of Cadmium in Pomacea canaliculate: Accumulation, Oxidative Stress, Microbial Community, and Transcriptome Analysis DOI Open Access

Mingxin Qiu,

Xiaoyang Bi,

Yuanyang Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 751 - 751

Published: Jan. 17, 2025

Cadmium (Cd) pollution poses an important problem, but limited information is available about the toxicology effects of Cd on freshwater invertebrates. We investigated accumulation, oxidative stress, microbial community changes, and transcriptomic alterations in apple snails (Pomacea canaliculata) under stress. The were exposed to 10 μg/L solution for 16 days, followed by a 16-day elimination period. Our results showed that liver accumulated highest concentration (17.41 μg/g), kidneys (8.00 μg/g) intestine-stomach (6.68 highlighting these tissues as primary targets accumulation. During period, concentrations decreased all tissues, with head-foot shell exhibiting over 30% rates. stress also resulted reduced activities superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST) compared control group. Notably, even after days depuration, enzyme did not return normal levels, indicating persistent toxicological effects. exposure significantly diversity gut microbiota P. canaliculata. Moreover, transcriptome analysis identified differentially expressed genes (DEGs) primarily associated lysosome function, motor proteins, protein processing endoplasmic reticulum, drug metabolism via cytochrome P450 (CYP450), arachidonic acid metabolism, ECM–receptor interactions. These findings suggest predominantly disrupts cellular transport metabolic processes. Overall, our study provides comprehensive insights into impact canaliculata emphasizes importance understanding mechanisms underlying toxicity aquatic organisms.

Language: Английский

Citations

3
Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics DOI Creative Commons
A. Chen, Ying Gong,

S. C. Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

3
Eating Fermented: Health Benefits of LAB-Fermented Foods DOI Creative Commons
Vincenzo Castellone, Elena Bancalari, Josep Rubert

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(11), P. 2639 - 2639

Published: Oct. 31, 2021

Lactic acid bacteria (LAB) are involved in producing a considerable number of fermented products consumed worldwide. Many those LAB foods recognized as beneficial for human health due to probiotic or their metabolites produced during food fermentation after digestion. In this review, we aim gather and discuss available information on the health-related effects LAB-fermented foods. particular, focused most widely such yoghurt, kefir, cheese, plant-based sauerkrauts kimchi.

Language: Английский

Citations

103
Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity DOI Open Access
Jordina Balaguer-Trias, Deepika Deepika, Marta Schuhmacher

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(3), P. 1368 - 1368

Published: Jan. 26, 2022

Over the last years, research has focused on microbiota to establish a missing link between neuronal health and intestine imbalance. Many studies have considered as critical regulators of gut-brain axis. The crosstalk central nervous system is mainly explained through three different pathways: neural, endocrine, immune pathways, intricately interconnected with each other. In day-to-day life, human beings are exposed wide variety contaminants that affect our intestinal alter bidirectional communication gut brain, causing disorders. interplay xenobiotics, neurotoxicity still not fully explored, especially for susceptible populations such pregnant women, neonates, developing children. Precisely, early exposure can trigger neurodevelopmental toxicity long-term diseases. There growing but limited specific mechanisms microbiota-gut-brain axis (MGBA), making it challenging understand effect environmental pollutants. this review, we discuss biological analyse role endocrine-disrupting chemicals: Bisphenol A (BPA), Chlorpyrifos (CPF), Diethylhexyl phthalate (DEHP), Per- polyfluoroalkyl substances (PFAS) in MGBA perturbations subsequent neurotoxicity. complexity changing nature pose significant challenges future research. However, emerging in-silico models able interpret meta-omics data promising option understanding processes help prevent

Language: Английский

Citations

59
An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer DOI Creative Commons

Vidya Sankarapandian,

Balu Alagar Venmathi Maran, Ramya Lakshmi Rajendran

et al.

Life, Journal Year: 2022, Volume and Issue: 12(1), P. 59 - 59

Published: Jan. 2, 2022

Probiotics are living microbes that play a significant role in protecting the host various ways. Gut microbiota is one of key players maintaining homeostasis. Cancer considered most causes death worldwide. Although cancer treatment has received much attention recent years, number people suffering from neoplastic syndrome continues to increase. Despite notable improvements field therapy, tackling been challenging due multiple properties cells and their ability evade immune system. alter immunological cellular responses by enhancing epithelial barrier stimulating production anti-inflammatory, antioxidant, anticarcinogenic compounds, thereby reducing burden growth. The present review focuses on mechanisms underlying probiotics prevention cancer.

Language: Английский

Citations

56
Heavy metals (HMs) pollution in the aquatic environment: Role of probiotics and gut microbiota in HMs remediation DOI

Apurva Kakade,

Monika Sharma, El‐Sayed Salama

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 223, P. 115186 - 115186

Published: Dec. 28, 2022

Language: Английский

Citations

51
Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

12