Aquaculture, Journal Year: 2021, Volume and Issue: 550, P. 737847 - 737847
Published: Dec. 23, 2021
Language: Английский
Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3211 - 3211
Published: Sept. 15, 2021
Metabolic diseases are serious threats to public health and related gut microbiota. Probiotics, prebiotics, synbiotics, postbiotics (PPSP) powerful regulators of microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects mechanisms PPSP on targeting microbiota worth discussing clarifying. Generally, benefit management, especially obesity type 2 diabetes mellitus. The underlying microbial-related mainly modulation composition, regulation microbial metabolites, improvement intestinal barrier function. Moreover, clinical trials showed benefits patients with diseases, while strategies gestational mellitus, optimal formula synbiotics need further study. This review fully summarizes relationship between probiotics, postbiotics, presents promising results one in dispute, attention is paid illustrates potential effects, which could contribute next research development PPSP.
Language: Английский
Citations
280
Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12
Published: June 20, 2022
In the last two decades, considerable interest has been shown in understanding development of gut microbiota and its internal external effects on intestine, as well risk factors for cardiovascular diseases (CVDs) such metabolic syndrome. The intestinal plays a pivotal role human health disease. Recent studies revealed that can affect host body. CVDs are leading cause morbidity mortality, patients favor death over chronic kidney For function host, molecules have to penetrate epithelium or surface cells host. Gut utilize trimethylamine, N-oxide, short-chain fatty acids, primary secondary bile acid pathways. By affecting these living cells, heart failure, atherosclerosis, hypertension, myocardial fibrosis, infarction, coronary artery Previous relation stroke pathogenesis consequences provide new therapeutic prospects. This review highlights interplay between metabolites addresses related interventions treatment CVDs.
Language: Английский
Citations
158
Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)
Published: May 11, 2022
Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders the gastrointestinal tract. Accumulating evidence shows that development IBD is always accompanied by dysbiosis gut microbiota (GM), causing decrease in prebiotic levels and an increase harmful metabolite levels. This leads to persistent immune response inflammation intestine, greatly impairing physiological function Short-chain fatty acids (SCFAs) are produced probiotic bacteria from fiber-rich diet cannot be digested directly. SCFAs with significant anti-inflammatory functions regulate prevent excessive response, thereby delaying clinical progression IBD. In this review, we summarize generation their potential therapeutic effects on Furthermore, suggest may modulate innate recognition cytokine production intervene Additional randomized controlled trials prospective cohort studies should also investigate impact SCFA. Video Abstract.
Language: Английский
Citations
145
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9452 - 9452
Published: Aug. 31, 2021
An expanding body of research asserts that the gut microbiota has a role in bone metabolism and pathogenesis osteoporosis. This review considers human composition its osteoclastogenesis healing process, specifically case Although natural physiologic processes osteoporosis disease are now relatively well known, recent literature suggests healthy microbiome is tied to homeostasis. Nevertheless, mechanism underlying this connection still somewhat enigmatic. Based on literature, relationship between microbiome, osteoblasts, osteoclasts, receptor activator nuclear factor-kappa-Β ligand (RANKL) contemplated explored review. Studies have proposed various mechanisms interaction with health, including micro-RNA, insulin-like growth factor 1, immune system mediation. However, alterations secondary pharmaceutical surgical interventions cannot be discounted discussed context clinical therapeutic consideration. The probiotics their action examined healing. known hypothesized interactions common drugs examined. Since dysbiosis can function as biomarker metabolic activity, it may also pharmacological nutraceutical (i.e., pre- probiotics) target promote
Language: Английский
Citations
126
iMeta, Journal Year: 2023, Volume and Issue: 2(1)
Published: Jan. 5, 2023
Abstract High‐fat diet (HFD) has been recognized as a primary factor in the risk of chronic disease. Obesity, diabetes, gastrointestinal diseases, neurodegenerative and cardiovascular diseases have long known with high worldwide incidence. In this review, influences gut microbiota their corresponding bacterial metabolites on mechanisms HFD‐induced are systematically summarized. Gut imbalance is also to increase susceptibility diseases. Several studies proven that HFD negative impact microbiota, exacerbating course many through increased populations Erysipelotrichaceae , facultative anaerobic bacteria, opportunistic pathogens. Since bile acids, lipopolysaccharide, short‐chain fatty trimethylamine N ‐oxide common features metabolites, we will explore possibility synergistic among those context Recent literature concerning mechanistic actions HFD‐mediated collected from PubMed, Google Scholar, Scopus. The aim review provide new insights into point out potential biomarkers microbiota.
Language: Английский
Citations
73
Microbiology Insights, Journal Year: 2023, Volume and Issue: 16
Published: Jan. 1, 2023
Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of by influencing development disorders. This review aims synthesize recent advances literature investigate implication SCFAs modulation obesity diabetes pathologies. For a better understanding relationships between metabolism, we need answer some questions: What is biochemistry SCFAs, how they are microbiota? bacteria producing which routes? How absorbed transported different mechanisms receptors? involved pathologies?
Language: Английский
Citations
43
The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 118, P. 109356 - 109356
Published: April 21, 2023
Language: Английский
Citations
43
Food Chemistry, Journal Year: 2024, Volume and Issue: 446, P. 138739 - 138739
Published: Feb. 16, 2024
Language: Английский
Citations
19
Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116791 - 116791
Published: Feb. 1, 2025
Language: Английский
Citations
2
Cells, Journal Year: 2022, Volume and Issue: 11(12), P. 1883 - 1883
Published: June 10, 2022
Obesity is characterized by an increase in body weight associated with exaggerated enlargement of the adipose tissue. has serious negative effects because it multiple pathological complications such as type 2 diabetes mellitus, cardiovascular diseases, cancer, and COVID-19. Nowadays, 39% world population obese or overweight, making obesity 21st century epidemic. also a mild, chronic, systemic inflammation. Accumulation fat tissue causes stress malfunction adipocytes, which then initiate Next, infiltrated cells innate immune system. Recently, become evident that neutrophils, most abundant leukocytes blood, are first infiltrating Neutrophils get activated release inflammatory factors recruit macrophages other cells. These cells, turn, perpetuate inflammation state producing cytokines chemokines can reach parts body, creating condition. In this review, we described recent findings on role neutrophils during initiation addition, discuss involvement generation obesity-related using prime example.
Language: Английский
Citations
60