Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155039 - 155039
Published: Aug. 20, 2023
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 203 - 220
Published: March 5, 2024
Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well modulate gut microbiota for maintaining homeostasis synchronously. In this study, a novel drug delivery system based metal polyphenol network (MPN) was constructed via coordination between epigallocatechin gallate (EGCG) and Fe
Language: Английский
Citations
28
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 26, 2025
Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(31), P. 5853 - 5872
Published: Jan. 1, 2022
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation.
Language: Английский
Citations
56
Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12
Published: Oct. 26, 2022
Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, butyrate, are one them. Nowadays, it is known butyrate key microbial metabolite. Therefore, the current review, we focused on sodium (NaB) context colorectal Notably, characterized by wide range beneficial properties/activities. Among others, influences function immune system, maintains intestinal barrier integrity, positively affects efficiency anti-cancer treatment, may reduce risk mucositis induced chemotherapy. Taking into consideration these facts, analyzed NaB (which salt butyric acid) its impact gut microbiota as well anti-tumor activity describing molecular mechanisms. Overall, available as, for instance, food with special medical purposes (depending country’s regulation), administration seems to be promising option cancer patients.
Language: Английский
Citations
42
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 250, P. 126167 - 126167
Published: Aug. 7, 2023
Language: Английский
Citations
35
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: July 20, 2023
Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.
Language: Английский
Citations
31
Korean Circulation Journal, Journal Year: 2023, Volume and Issue: 53(8), P. 499 - 499
Published: Jan. 1, 2023
Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% deaths worldwide. Although risk factors CVDs have been well understood various treatment preventive measures established, mortality rate financial burden expected to grow exponentially over time due changes in lifestyles increasing life expectancies present generation. Recent advancements metagenomics metabolomics analysis identified gut microbiome its associated metabolites as potential CVDs, suggesting possibility developing effective novel therapeutic strategies against CVD. In addition, evidence has demonstrated alterations ratio Firmicutes Bacteroidetes imbalance microbial-dependent metabolites, short-chain fatty acids trimethylamine N-oxide, play a crucial role pathogenesis However, exact mechanism action remains undefined this day. review, we focus on compositional related CVDs. Moreover, targeting discussed.
Language: Английский
Citations
29
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 5, 2023
Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though pathogenesis IBD remains unclear, diet increasingly recognized as pivotal factor influencing its onset and progression. Fatty acids, essential components dietary lipids, play diverse roles in IBD, ranging from anti-inflammatory immune-regulatory functions to gut-microbiota modulation barrier maintenance. Short-chain fatty acids (SCFAs), products indigestible fiber fermentation by gut microbiota, have strong properties are seen key protective factors against IBD. Among long-chain saturated trans ω-6 polyunsaturated exhibit pro-inflammatory effects, while oleic acid ω-3 display actions. Lipid mediators derived serve bioactive molecules, immune cell offering both benefits. Recent research has also highlighted potential medium- very modulating inflammation, mucosal barriers, microbiota Given these insights, intervention supplementation with short-chain emerging therapeutic strategies for This review elucidates impact various lipid on delves into avenues stemming compounds.
Language: Английский
Citations
29
Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2749 - 2749
Published: Oct. 11, 2023
The human oral microbiome has emerged as a focal point of research due to its profound implications for health. involvement short-chain fatty acids in composition, health, and chronic inflammation is gaining increasing attention. In this narrative review, the results early vitro, vivo, pilot clinical studies projects are presented order define boundaries new complicated issue. According results, current data disputable ambiguous. When investigating role SCFAs health disease, it crucial distinguish between their local GI effects systemic influences. Locally, part normal microbiota metabolism, but increased formation usually attribute dysbiosis; excess participate development diseases biota gut colonization dysbiosis. On other hand, number have established positive impact on whole, including reduction inflammation, improvement metabolic processes, decrease some types cancer incidence. Thus, complex sophisticated approach with consideration origin localization SCFA function assessment demanded. Therefore, more research, especially needed investigate relationship disease potential prevention treatment.
Language: Английский
Citations
27
Applied Sciences, Journal Year: 2023, Volume and Issue: 13(8), P. 4726 - 4726
Published: April 9, 2023
Immune system modulation is an intriguing part of scientific research. It well established that the immune plays a crucial role in orchestrating cellular and molecular key mediators, thus establishing powerful defense barrier against infectious pathogens. Gut microbiota represent complex community approximately hundred trillion microorganisms live mammalian gastrointestinal (GI) tract, contributing to maintenance gut homeostasis via regulation innate adaptive responses. However, impairment crosstalk between intestinal immunity may reflect on detrimental health issues. In this context, many studies have indicated probiotics their bioactive compounds, such as bacteriocins short chain fatty acids (SCFAs), display distinct immunomodulatory properties through which they suppress inflammation enhance restoration microbial diversity pathological states. This review highlights fundamental features probiotics, bacteriocins, SCFAs, make them ideal therapeutic agents for amelioration inflammatory autoimmune diseases. also describes underlying mechanisms emphasizes how influence function cells involved regulating homeostasis. Finally, it discusses future perspectives challenges administration individuals.
Language: Английский
Citations
26