Therapeutically harnessing extracellular vesicles

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(5), P. 379 - 399

Published: March 2, 2022

Language: Английский

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Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Nature Biomedical Engineering, Journal Year: 2023, Volume and Issue: 7(7), P. 887 - 900

Published: Jan. 12, 2023

Language: Английский

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Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(2), P. 763 - 763

Published: Jan. 14, 2021

Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem that support homeostasis during tissue regeneration. In the last decade, cell therapies based on use of MSCs have emerged as a promising strategy in field regenerative medicine. Although these possess robust therapeutic properties can be applied treatment different diseases, variables preclinical and clinical trials lead to inconsistent outcomes. MSC effects result from secretion bioactive molecules affected by either local microenvironment or culture conditions. Hence, paracrine action is currently being explored several settings using conditioned medium (CM) MSC-derived exosomes (EXOs), where products modulate responses types injuries. this scenario, mechanisms provide framework for enhancing benefits, composition secretome modulated priming MSCs. review, we examine literature tool enhance their applicable main processes involved regeneration, including reduction fibrosis, immunomodulation, stimulation angiogenesis, resident progenitor cells, thereby providing new insights MSCs-derived products.

Language: Английский

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Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: April 26, 2023

Abstract Wound healing is a dynamic and highly sequential process involving series of overlapping spatial temporal phases, including hemostasis, inflammation, proliferation, tissue remodeling. Mesenchymal stem cells (MSCs) are multipotent with self-renewal, multidirectional differentiation potential, paracrine regulation. Exosomes subcellular vesicular components 30–150 nm in size novel carriers intercellular communication regulating the biological behaviors skin cells. Compared to MSCs, MSC-derived exosomes (MSC-exos) possess lower immunogenicity, easy storage, effective activity. MSC-exos, mainly derived from adipose-derived (ADSCs), bone marrow-derived MSCs (BMSCs), human umbilical cord (hUC-MSCs), other cell types, play role shaping activity fibroblasts, keratinocytes, immune cells, endothelial diabetic wounds, inflammatory wound repair, even wound-related keloid formation. Therefore, this study focuses on specific roles mechanisms different MSC-exos healing, as well current limitations various perspectives. Deciphering properties crucial providing promising cell-free therapeutic tool for cutaneous regeneration. Graphical

Language: Английский

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Emerging mechanisms of obesity-associated immune dysfunction

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 20(3), P. 136 - 148

Published: Dec. 21, 2023

Language: Английский

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Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Periodontology 2000, Journal Year: 2024, Volume and Issue: 94(1), P. 257 - 414

Published: Feb. 1, 2024

Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array diseases/conditions. Over 5000 publications currently being published yearly on this topic, number is only expected dramatically increase novel strategies continue developed. Today exosomes have been applied numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), procedures (antiaging, bone regeneration, cartilage/joint osteoarthritis, cutaneous wounds, dental dermatology/skin erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord vascular regeneration), cancer therapy (breast, colorectal, gastric osteosarcomas), immune function (allergy, autoimmune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review first its kind aimed at summarizing extensive potential broad range disorders.

Language: Английский

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Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

Pharmaceutics, Journal Year: 2020, Volume and Issue: 13(1), P. 3 - 3

Published: Dec. 22, 2020

Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have attracted increasing attention due to their inherent ability shuttle proteins, lipids and genes between cells natural affinity target cells. Their intrinsic features such as stability, biocompatibility, low immunogenicity overcome biological barriers, prompted interest in using exosomes drug delivery vehicles, especially for gene therapy. Evidence indicates that play roles both immune stimulation tolerance, regulating signaling inflammation. To date, exosome-based nanocarriers delivering small molecule drugs been developed treat many prevalent autoimmune diseases. This review highlights the key of therapeutic cargo, use targeting peptide, loading method administration route with a broad focus. In addition, we outline current state evidence field systems systemic lupus erythematosus (SLE), evaluating derived from various cell types engineered exosomes.

Language: Английский

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Antibacterial, adhesive, and MSC exosomes encapsulated microneedles with spatio-temporal variation functions for diabetic wound healing

Nano Today, Journal Year: 2022, Volume and Issue: 47, P. 101630 - 101630

Published: Oct. 3, 2022

Language: Английский

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Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 423 - 452

Published: Oct. 20, 2022

Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain affects patient's quality of life. However, currently, there lack effective early diagnosis treatment. Although stem cells can promote cartilage repair treat OA, problems such as immune rejection tumorigenicity persist. Extracellular vesicles (EVs) transmit genetic information from donor mediate intercellular communication, which considered functional paracrine factor cells. Increasing evidences suggest EVs may play an essential complex role in the pathogenesis, diagnosis, treatment OA. Here, we introduced OA progression by influencing inflammation, metabolism, aging. Next, discussed blood, synovial fluid, joint-related for diagnosis. Moreover, outlined potential modified unmodified their combination with biomaterials therapy. Finally, discuss deficiencies put forward prospects challenges related to application field

Language: Английский

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Extracellular vesicles in cancer therapy

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 296 - 309

Published: June 8, 2022

Language: Английский

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