International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15468 - 15468
Published: Oct. 23, 2023
Aging
is
a
natural,
gradual,
and
inevitable
process
associated
with
series
of
changes
at
the
molecular,
cellular,
tissue
levels
that
can
lead
to
an
increased
risk
many
diseases,
including
cancer.
The
most
significant
genomic
level
(DNA
damage,
telomere
shortening,
epigenetic
changes)
non-genomic
are
referred
as
hallmarks
aging.
aging
cancer
intertwined.
Many
studies
have
focused
on
hallmarks,
but
also
important
may
additionally
cause
damage
increase
expression
hallmarks.
Understanding
cancer,
how
they
intertwined,
development
approaches
could
influence
these
thus
function
not
only
slow
prevent
In
this
review,
we
focus
changes.
We
discuss
cell
senescence,
disruption
proteostasis,
deregualation
nutrient
sensing,
dysregulation
immune
system
function,
intercellular
communication,
mitochondrial
dysfunction,
stem
exhaustion
dysbiosis.
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
15(1), P. 1 - 30
Published: Dec. 14, 2023
Aging
is
a
dynamic,
time-dependent
process
that
characterized
by
gradual
accumulation
of
cell
damage.
Continual
functional
decline
in
the
intrinsic
ability
living
organisms
to
accurately
regulate
homeostasis
leads
increased
susceptibility
and
vulnerability
diseases.
Many
efforts
have
been
put
forth
understand
prevent
effects
aging.
Thus,
major
cellular
molecular
hallmarks
aging
identified,
their
relationships
age-related
diseases
malfunctions
explored.
Here,
we
use
data
from
CAS
Content
Collection
analyze
publication
landscape
recent
aging-related
research.
We
review
advances
knowledge
delineate
trends
research
advancements
on
factors
attributes
across
time
geography.
also
current
concepts
related
molecular,
cellular,
organismic
level,
age-associated
diseases,
with
attention
brain
health,
as
well
biochemical
processes
associated
Major
outlined,
correlations
features
are
hope
this
will
be
helpful
for
apprehending
field
mechanisms
progression,
an
effort
further
solve
remaining
challenges
fulfill
its
potential.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5862 - 5862
Published: March 20, 2023
Hematopoietic
stem
cells
(HSCs)
support
haematopoiesis
throughout
life
and
give
rise
to
the
whole
variety
of
immune
system.
Developing
in
early
embryo,
passing
through
precursor
stage,
maturing
into
first
HSCs,
they
undergo
a
fairly
large
number
divisions
while
maintaining
high
regenerative
potential
due
repair
activity.
This
is
greatly
reduced
adult
HSCs.
They
go
state
dormancy
anaerobic
metabolism
maintain
their
stemness
life.
However,
with
age,
changes
occur
pool
HSCs
that
negatively
affect
effectiveness
immunity.
Niche
aging
accumulation
mutations
age
reduces
ability
self-renew
differentiation
potential.
accompanied
by
decrease
clonal
diversity
disturbance
lymphopoiesis
(decrease
formation
naive
T-
B-cells)
predominance
myeloid
haematopoiesis.
Aging
also
affects
mature
cells,
regardless
HSC,
therefore,
phagocytic
activity
intensity
oxidative
burst
decrease,
efficiency
processing
presentation
antigens
impaired.
innate
adaptive
immunity
produce
factors
form
chronic
inflammatory
background.
All
these
processes
have
serious
negative
impact
on
protective
properties
system,
increasing
inflammation,
risk
developing
autoimmune,
oncological,
cardiovascular
diseases
age.
Understanding
mechanisms
reducing
comparative
analysis
embryonic
features
will
allow
us
get
closer
deciphering
programs
for
development,
aging,
regeneration
rejuvenation
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(9), P. 931 - 931
Published: Aug. 31, 2024
Aging
is
a
fundamental
biological
process
characterized
by
progressive
decline
in
physiological
functions
and
an
increased
susceptibility
to
diseases.
Understanding
aging
at
the
molecular
level
crucial
for
developing
interventions
that
could
delay
or
reverse
its
effects.
This
review
explores
integration
of
machine
learning
(ML)
with
multi-omics
technologies-including
genomics,
transcriptomics,
epigenomics,
proteomics,
metabolomics-in
studying
hallmarks
develop
personalized
medicine
interventions.
These
include
genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
disabled
macroautophagy,
deregulated
nutrient
sensing,
mitochondrial
dysfunction,
cellular
senescence,
stem
cell
exhaustion,
altered
intercellular
communication,
chronic
inflammation,
dysbiosis.
Using
ML
analyze
big
complex
datasets
helps
uncover
detailed
interactions
pathways
play
role
aging.
The
advances
can
facilitate
discovery
biomarkers
therapeutic
targets,
offering
insights
into
anti-aging
strategies.
With
these
developments,
future
points
toward
better
understanding
process,
aiming
ultimately
promote
healthy
extend
life
expectancy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3521 - 3521
Published: March 20, 2024
The
phrase
“Let
food
be
thy
medicine…”
means
that
can
a
form
of
medicine
and
food;
in
other
words,
the
diet
we
eat
have
significant
impact
on
our
health
well-being.
Today,
this
is
gaining
prominence
as
more
scientific
evidence
suggests
one’s
help
prevent
treat
disease.
A
rich
fruits,
vegetables,
whole
grains,
lean
protein
reduce
risk
heart
disease,
cancer,
diabetes,
problems
and,
hand,
processed
foods,
added
sugars,
saturated
fats
increase
same
diseases.
Electrophilic
compounds
health,
they
are
molecules
covalently
modify
cysteine
residues
present
thiol-rich
Keap1
protein.
These
bind
to
activate
NRF2,
which
promotes
its
translocation
nucleus
binding
DNA
ARE
region,
triggering
antioxidant
response
protecting
against
oxidative
stress.
include
polyphenols
flavonoids
nucleophilic
but
converted
electrophilic
quinones
by
metabolic
enzymes
such
polyphenol
oxidases
(PPOs)
sulfur
foods
Brassica
genus
(broccoli,
cauliflower,
cabbage,
Brussel
sprouts,
etc.)
garlic.
This
review
summarizes
current
knowledge
subject.
Journal of Internal Medicine,
Journal Year:
2022,
Volume and Issue:
295(4), P. 400 - 415
Published: June 15, 2022
Abstract
Nutrition
profoundly
influences
the
risk
for
many
age‐related
diseases.
Whether
nutrition
human
aging
biology
directly
is
less
clear.
Studies
in
different
animal
species
indicate
that
reducing
food
intake
(“caloric
restriction”
[CR])
can
increase
lifespan
and
delay
onset
of
diseases
biological
hallmarks
aging.
Obesity
has
been
described
as
“accelerated
aging”
therefore
health
benefits
generated
by
CR
both
obesity
may
occur
via
similar
mechanisms.
Beyond
calorie
intake,
studies
based
on
nutritional
geometry
have
shown
protein
interaction
between
dietary
carbohydrates
influence
lifespan.
where
animals
are
calorically
restricted
providing
free
access
to
diluted
diets
had
impact
than
those
given
a
reduced
aliquot
each
day
fasting
meals.
This
drawn
attention
role
aging,
exploration
effects
various
regimes.
Although
definitive
clinical
trials
would
need
be
unfeasibly
long
unrealistically
controlled,
there
good
evidence
from
experiments
some
interventions
CR,
manipulating
macronutrients,
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Skeletal
muscles
and
bones
are
closely
connected
anatomically
functionally.
Age-related
degeneration
in
these
tissues
is
associated
with
physical
disability
the
elderly
significantly
impacts
their
quality
of
life.
Understanding
mechanisms
age-related
musculoskeletal
tissue
crucial
for
identifying
molecular
targets
therapeutic
interventions
skeletal
muscle
atrophy
osteoporosis.
The
Hippo
pathway
a
recently
identified
signaling
that
plays
critical
roles
development,
homeostasis,
regeneration.
Yes-associated
protein
(YAP)
transcriptional
coactivator
PDZ-binding
motif
(TAZ)
key
downstream
effectors
mammalian
pathway.
This
review
highlights
fundamental
YAP
TAZ
homeostatic
maintenance
regeneration
bones.
YAP/TAZ
play
significant
role
stem
cell
function
by
relaying
various
environmental
signals
to
cells.
osteoporosis
related
dysfunction
or
senescence
triggered
dysregulation
resulting
from
reduced
mechanosensing
mitochondrial
In
contrast,
activation
can
suppress
may
be
used
as
basis
development
potential
strategies.
Thus,
targeting
holds
alleviating
bone
improving
life
elderly.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: July 2, 2024
Abstract
Background
Recent
studies
have
proved
the
role
of
autophagy
in
mesenchymal
stem
cell
(MSCs)
function
and
regenerative
properties.
How
by
which
mechanism
modulation
can
affect
juxtacrine
interaction
MSCs
should
be
addressed.
Here,
was
investigated
formation
tunneling
nanotubes
(TNTs)
homotypic
mitochondrial
donation.
Methods
were
incubated
with
15
µM
Metformin
(Met)
and/or
3
3-methyladenine
(3-MA)
for
48
h.
The
TNTs
assessed
using
bright-field
SEM
images.
mitochondria
density
ΔΨ
values
monitored
flow
cytometry
analysis.
Using
RT-PCR
protein
array,
close
shared
mediators
between
autophagy,
apoptosis,
Wnt
signaling
pathways
also
monitored.
total
fatty
acid
profile
gas
chromatography.
Result
Data
indicated
increase
TNT
length
number,
along
other
projections
after
induction
while
these
features
blunted
3-MA-treated
(
p
<
0.05).
Western
blotting
revealed
significant
reduction
Rab8
p-FAK
0.05),
indicating
inhibition
assembly
vesicle
transport.
Likewise,
stimulation
increased
autophagic
flux
membrane
integrity
compared
to
MSCs.
Despite
findings,
levels
Miro1
2
unchanged
inhibition/stimulation
>
We
found
that
protein,
transcription
several
related
apoptosis
involved
different
bioactivities.
confirmed
profound
mono
polyunsaturated/saturated
ratio
exposed
stimulator.
Conclusions
In
summary,
could
is
required
Thus,
creates
a
promising
perspective
efficiency
cell-based
therapies.
