Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189214 - 189214
Published: Nov. 1, 2024
Language: Английский
Bone Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Aug. 5, 2024
Abstract Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including skeletal immune systems. Recent studies have elucidated intricate bidirectional interactions between these two In this review, we provide comprehensive synthesis molecular mechanisms cell ageing. We further discuss how age-related changes influence system consequent impact alterations on system. Finally, highlight clinical implications findings propose potential strategies to promote healthy ageing reduce pathologic both
Language: Английский
Citations
19
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: May 22, 2024
Abstract Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying the genome. While long considered a nexus for damage, role in aging is under-appreciated. The consequential promotion organismal phenotypes evidenced by an extensive list hereditary accelerated disorders marked molecular defects factors promote and operate uniquely response. Additionally, recent studies have revealed cellular pathways elicited align with designated hallmarks aging. Here we review advances demonstrating as ultimate driver senescence We discuss clinical implications intriguing links between including application senotherapeutic approaches context stress.
Language: Английский
Citations
17
Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 542 - 542
Published: March 30, 2024
Chronic anemia is more prevalent in people living with HIV (PLWH) compared to the general population. The mechanisms that drive chronic are multifaceted and include functional impairment of hematopoietic stem cells, dysregulation erythropoietin production, persistent immune activation. inflammation from infection adversely affects erythropoiesis, erythrocyte lifespan, response, leading a heightened risk co-infections such as tuberculosis, severe anemia, increased mortality. Additionally, exacerbates progression HIV-associated nephrotoxicity contributes cardiovascular through activation inflammation. This review highlights cardinal role link connecting complications PLWH, emphasizing need for universal understanding these interconnected pathways targeted interventions.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6455 - 6455
Published: March 29, 2023
In multicellular organisms, interactions between cells and intercellular communications form the very basis of organism's survival, functioning its systems, maintenance homeostasis adequate response to environment. The accumulated experimental data point particular importance in determining fate cells, as well their differentiation plasticity. For a long time, it was believed that properties behavior were primarily governed by secreted or membrane-bound ligands with corresponding receptors, direct adhesion contacts. this review, we describe various types other, non-classical have recently come into limelight-in particular, broad repertoire extracellular vesicles membrane protrusions. These are mediated large macromolecular structural functional ensembles, explore here mechanisms underlying formation present current reveal roles multiple biological processes. effects these new normal pathological states, therapeutic applications, also discussed. in-depth study novel interaction is required for establishment effective approaches control modification cell both basic research development radically strategies.
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15653 - 15653
Published: Oct. 27, 2023
The phenomenon of accumulation senescent adaptive immunity cells in the elderly is attracting attention due to increasing risk global epidemics and aging population. Elderly people are predisposed various infectious age-related diseases at higher vaccination failure. increases background inflammation, “Inflammaging”, causing lymphocyte exhaustion cardiovascular, neurodegenerative, autoimmune cancer diseases. Here, we present a comprehensive contemporary review mechanisms phenotype senescence immune system. Although modern research has not yet identified specific markers lymphocytes, several sets facilitate separation population based on normal memory exhausted for further genetic functional analysis. reasons predisposition CD8+ T-lymphocytes compared CD4+ also discussed. We point out approaches senescent-lymphocyte-targeting using small molecules (senolytics), antibodies immunization against cells. suppression most relevant area aimed developing anti-aging anti-cancer therapy prolonging lifespan
Language: Английский
Citations
13
Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 295(5), P. 634 - 650
Published: March 4, 2024
Abstract Background The immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is crucial for preventing infections and relapse enhancing graft‐versus‐tumor effects. B cells play an important role in humoral immunity regulation, but their allo‐HSCT has not been well studied. Methods In this study, we analyzed the dynamics of 252 patients who underwent 2 years assessed impact factors on B‐cell correlations with survival outcomes, as development stages bone marrow subsets peripheral blood. Results We found that was consistent blood ( p = 0.232). delayed by male gender, age >50, older donor age, occurrence chronic acute graft‐versus‐host disease, fungi cytomegalovirus. analysis revealed lower had higher risks death relapse. More importantly, used propensity score matching to obtain conclusion post‐1‐year better females. Meanwhile, using mediation analysis, proposed age‐B cells‐survival axis at month 12 posttransplant mediated effect patient 0.013). also younger showed more immature 0.037). Conclusion Our findings provide valuable insights optimizing management improving efficacy safety allo‐HSCT.
Language: Английский
Citations
5
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(15), P. 3604 - 3625
Published: Jan. 1, 2024
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Language: Английский
Citations
4
Cytokines and inflammation, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Despite the success achieved in increasing average life expectancy, problems of improving quality elderly and old people, prevention therapy age-associated diseases geriatric syndromes are still relevant. The immune system plays a key role aging process, functioning which undergoes wide range changes, collectively called "immunosenescence". Aging cells is associated with shortening telomeric regions chromosomes, loss protein homeostasis (proteostasis), mitochondrial dysfunction, DNA damage, oxidative stress. Senescent marked by resistance to apoptosis, cell cycle arrest abnormal production proinflammatory cytokines, leading development chronic low-grade inflammation. In this case, effector mechanisms response depleted, accompanied low ability adequately respond an antigenic stimulus. Thymus atrophy, depletion bone marrow niches, myeloid bias hematopoiesis change ratio lymphocyte subsets occur. addition, functions neutrophilic granulocytes impaired, but nature their during immunosenescence has not been sufficiently studied, so additional studies needed establish granulocyte dysfunctions immunosenescence.
Language: Английский
Citations
0
Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(3)
Published: March 1, 2025
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health homeostasis of individuals. Dysregulation HSPC function can lead to blood-related diseases, including cancer. Despite its importance, our understanding genes pathways underlying development associated pathological mechanisms remains limited. To elucidate these unknown mechanisms, we analyzed databases patients with disorders performed functional gene studies using zebrafish. We employed bioinformatics tools explore three public focusing on myelodysplastic syndrome (MDS) related model studies. This analysis identified significant alterations several genes, especially SMC2 other condensin-related MDS. further investigate Smc2 hematopoiesis, generated smc2 loss-of-function zebrafish mutants CRISPR mutagenesis. Further analyses revealed that depletion induced G2/M cycle arrest HSPCs, leading their maintenance expansion failure. Notably, although condensin II subunits (ncaph2, ncapg2, ncapd3) were essential for maintenance, I did not affect development. These findings emphasize crucial ensuring healthy hematopoiesis via promoting proliferation.
Language: Английский
Citations
0
npj Aging, Journal Year: 2025, Volume and Issue: 11(1)
Published: May 2, 2025
Aging of hematopoietic and immune system (HIS) leads to cellular senescence dysregulation, contributing age-related diseases. Here, we show that Procyanidin C1 (PCC1), a compound with both senolytic senomorphic properties, can counteract aging-related changes in HIS. Using single-cell RNA sequencing validation experiments, found aging induced senescence, inflammation, dysregulation the bone marrow spleen tissues mice. Long-term PCC1 treatment improved key physiological parameters especially grip strength aged Further analysis revealed PCC1's broad geroprotective effects on HIS, including an increase proportion B cells (BCs) stem (HSCs), suppression senescence-associated markers, restoration normal processes. Specifically, mitigated inflammation restored homeostasis BCs by suppressing Cebpb expression age-associated BCs. Moreover, reversed aging-induced alterations HSCs through upregulating Nedd4 CD62L-Ca2+ axis expression. Finally, identified senescent (SnCs) using machine learning gene set enrichment analysis, revealing apoptosis SnCs regulated their metabolic processes, particularly granulocytes myeloid cells. The experimental further confirmed vivo vitro. Overall, holds potential as therapeutic agent for alleviating dysfunction promoting healthy via effects.
Language: Английский
Citations
0