The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 12, P. 394 - 394

Published: Feb. 5, 2024

Background Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze association on clinical outcome hospitalized patients. Methods A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value=0.019). Serum moderate (p-value=0.031). Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease DOI Creative Commons

Huang Limi,

Zhiwei Song, Chaosheng Lu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.

Language: Английский

Citations

0
Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence DOI
Luigi di Filippo,

Mauro Doga,

Francesca Mangini

et al.

Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Vitamin D Supplementation in Neonatal and Infant MIS-C Following COVID-19 Infection DOI Open Access
Manuela Rizzi,

Vincenzo Avellis,

Alessandro Messina

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3712 - 3712

Published: March 27, 2024

To date, the SARS-CoV-2 pandemic still represents a great clinical challenge worldwide, and effective anti-COVID-19 drugs are limited. For this reason, nutritional supplements have been investigated as adjuvant therapeutic approaches in disease management. Among such supplements, vitamin D has gained interest, due to its immunomodulatory anti-inflammatory actions both adult pediatric populations. Even if there is conflicting evidence about prevention and/or mitigation effectiveness infection, several studies demonstrated strict correlation between hypovitaminosis severity acute COVID-19 MIS-C (multisystem inflammatory syndrome children). This narrative review offers resume of state art D’s role immunity use context current pandemic, specially focusing on manifestations MIS-C. It seems biologically reasonable that interventions aimed at normalizing circulating levels could be beneficial. help clinicians establishing correct prophylaxis supportive therapy with D, well-designed adequately statistically powered trials involving populations needed. Moreover, will also discuss few other nutraceuticals evaluated context.

Language: Английский

Citations

3
Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes DOI Creative Commons
William B. Grant, Fatme Al Anouti, Barbara J. Boucher

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 994 - 994

Published: March 23, 2023

Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart and stroke), type 2 diabetes, hypertension, kidney stroke, infectious acute respiratory tract COVID-19, influenza, pneumonia, well adverse pregnancy outcomes. The respective is based on ecological observational studies, randomized controlled trials, mechanistic Mendelian randomization studies. However, trials supplementation have largely failed to show benefits, probably due poor design analysis. In this work, we aim use best available beneficial estimate expected reduction in incidence mortality rates D-related Kingdom Saudi Arabia United Arab Emirates if minimum serum 25(OH)D concentrations were be raised 30 ng/mL. Estimated reductions by 25% for myocardial infarction incidence, 35% stroke 20 mortality, cancer depicted a promising raising 25(OH)D. Methods increase at population level could include food fortification with

Language: Английский

Citations

8
Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond DOI Creative Commons
Lucreția Anghel, Corina Manole,

Aurel Nechita

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2362 - 2362

Published: Aug. 23, 2023

The coronavirus disease (COVID-19) pandemic caused by the novel SARS-CoV-2 has had a profound impact on global health, leading to surge in research better understand pathophysiology of disease. Among various aspects under investigation, disruptions mineral homeostasis have emerged as critical area interest. This review aims provide an overview current evidence linking calcium, phosphorus and magnesium abnormalities with COVID-19 infection explores potential implications beyond acute phase Beyond COVID-19, suggests these long-term health outcomes. Persistent alterations levels been linked increased cardiovascular risk, skeletal complications metabolic disorders, warranting continuous monitoring management post-COVID-19 patients.

Language: Английский

Citations

8
Understanding the Immune-Endocrine Effects of Vitamin D in SARS-CoV-2 Infection: A Role in Protecting against Neurodamage DOI Creative Commons
Emanuele Gotelli, Stefano Soldano, Elvis Hysa

et al.

NeuroImmunoModulation, Journal Year: 2023, Volume and Issue: 30(1), P. 185 - 195

Published: Jan. 1, 2023

Calcitriol and hydroxyderivatives of lumisterol tachisterol are secosteroid hormones with immunomodulatory anti-inflammatory properties. Since the beginning COVID-19 pandemic, several studies have correlated deficient serum concentrations vitamin D<sub>3</sub> (calcifediol) increased severity course SARS-CoV-2 infection. Among systemic complications, subjective (anosmia, ageusia, depression, dizziness) objective (ischemic stroke, meningoencephalitis, myelitis, seizures, Guillain-Barré syndrome) neurological symptoms been reported in up to 80% severe patients. In this narrative review, we will resume pathophysiology infection mechanisms acute chronic damage. can disrupt integrity endothelial cells blood-brain barrier (BBB) enter nervous central system. Invasion pro-inflammatory cytokines polarization astrocytes microglia always a sense together pro-coagulative phenotype cerebral response both immune invasion (immunothrombosis) major drivers neurodamage. could play an adjuvant role neuroprotection through mitigation neuroinflammation protection BBB. Dedicated on topic currently lacking desirable confirm link between

Language: Английский

Citations

7
Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease DOI Creative Commons
Luigi di Filippo,

Umberto Terenzi,

Giovanni Di Ienno

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 86(1), P. 119 - 123

Published: June 10, 2024

Low vitamin D levels were reported to negatively influence the outcomes of acute COVID-19, as well other biochemical markers linked including microRNAs (miRNAs). This study aimed prospectively evaluate miRNAs and relationship in predicting COVID-19 outcomes.

Language: Английский

Citations

2
Changes in vitamin D status among adults from the COVID-19 pandemic to post-pandemic normality DOI Creative Commons
Yanzhao Chen,

Guilian Kong

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 2, 2024

The COVID-19 pandemic has prompted widespread lockdown measures globally, significantly impacting daily activities and outdoor exposure. This study investigates the effect of on vitamin D levels prevalence deficiency in adult population, with a focus gender-specific differences.

Language: Английский

Citations

2
Response to the Letter to the Editor From Min et al: Low Vitamin D Levels are Associated With Long COVID Syndrome in COVID-19 Survivors DOI
Luigi di Filippo, Stefano Frara, Andrea Giustina

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(1), P. e438 - e439

Published: June 12, 2023

Journal Article Response to the Letter Editor From Min et al: Low Vitamin D Levels are Associated With Long COVID Syndrome in COVID-19 Survivors Get access Luigi di Filippo, Filippo Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University IRCCS Hospital, 20132 Milano, Italy Search for other works by this author on: Oxford Academic Google Scholar Stefano Frara, Frara Andrea Giustina Correspondence: Giustina, U.O. Endocrinologia, Ospedale Raffaele, Via Olgettina 60, Italy. Email: [email protected]. https://orcid.org/0000-0001-6783-3398 The Clinical Endocrinology & Metabolism, Volume 109, Issue 1, January 2024, Pages e438–e439, https://doi.org/10.1210/clinem/dgad327 Published: 12 June 2023 history Received: 26 May Editorial decision: 30 Corrected typeset: 04 July

Language: Английский

Citations

6
Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 394 - 394

Published: Sept. 11, 2023

Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze impact on clinical outcome hospitalized patients. Methods: A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value <0.001). Serum moderate Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions: having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

Citations

6