Environmental factors shaping the gut microbiome in a Dutch population

Nature, Journal Year: 2022, Volume and Issue: 604(7907), P. 732 - 739

Published: April 13, 2022

Language: Английский

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Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 125, P. 698 - 761

Published: March 5, 2021

There is increasing knowledge regarding the role of microbiome in modulating brain and behaviour. Indeed, actions microbial metabolites are key for appropriate gut-brain communication humans. Among these metabolites, short-chain fatty acids, tryptophan, bile acid metabolites/pathways show strong preclinical evidence involvement various aspects function With identification neuroactive modules, new predictive tools can be applied to existing datasets. We identified 278 studies relating human microbiota-gut-brain axis which included sequencing data. This spanned across psychiatric neurological disorders with a small number also focused on normal behavioural development. consistent bioinformatics pipeline, thirty-five datasets were reanalysed from publicly available raw files remainder summarised collated. studies, we uncovered disease-related alterations metabolic pathways Alzheimer's Disease, schizophrenia, anxiety depression. Amongst that could not reanalysed, many technical limitations hindered discovery specific biomarkers microbes or conserved studies. Future warranted confirm our findings. propose guidelines future analysis increase reproducibility consistency within field.

Language: Английский

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The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3258 - 3258

Published: July 23, 2023

The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention treatment strategies for disorders. Several gut microbiota, especially Firmicutes Bacteroidetes, are demonstrated affect health through microbiota-gut-brain axis, the microbiota dysbiosis can be related disorders, such as anxiety, depression, other On hand, dietary components, including probiotics Lactobacillus Bifidobacterium), prebiotics fiber alpha-lactalbumin), synbiotics, postbiotics short-chain fatty acids), dairy products, spices Zanthoxylum bungeanum, curcumin, capsaicin), fruits, vegetables, medicinal herbs, so on, could exert protective effects against by enhancing beneficial while suppressing harmful ones. In this paper, disorder-associated summarized. addition, components on targeting discussed. This paper helpful develop some natural products into pharmaceuticals functional foods prevent treat

Language: Английский

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Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

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Ketogenic Diet: A Dietary Intervention via Gut Microbiome Modulation for the Treatment of Neurological and Nutritional Disorders (a Narrative Review)

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3566 - 3566

Published: Aug. 30, 2022

The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. benefits of KD further expanded to other neurological diseases, including Alzheimer’s autism spectrum disorder, and nutritional disorder (obesity). Although therapeutic efficacy generally accepted, there is limited knowledge about its underlying mechanism action, particularly effect on our gut microbiome. Gut dysbiosis proposed be involved those can promote microbiota remodeling that may assist recovery. This review explores applications KD, roles microbiome diseases obesity, as well present information suggests significant altering improve disease symptoms, mainly by incrementing Bacteroidetes Firmicutes (B/F) ratio reducing Proteobacteria certain cases. However, current gaps call for continued research understand better profile altered KD.

Language: Английский

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Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 13, 2023

Abstract Evidence from cross-sectional human studies, and preliminary microbial-based intervention have implicated the microbiota-gut-brain axis in neurobiology of autism spectrum disorder (ASD). Using a prospective longitudinal study design, we investigated developmental profile fecal microbiota metabolome infants with ( n = 16) without 19) family history ASD across first 36 months life. In addition, general levels were evaluated using Mullen Scales Early Learning (MSEL) test at 5 age, ADOS-2 age. At elevated-likelihood (EL) harbored less Bifidobacterium more Clostridium Klebsiella species compared to low-likelihood (LL). Untargeted metabolic profiling highlighted that LL excreted greater amount γ-aminobutyric acid (GABA) months, which progressively declined Similar age-dependent patterns not observed EL group, GABA being consistently low all timepoints. Integrated microbiome-metabolome analysis showed positive correlation between negative associations species. vitro experiments supported these observations demonstrating bifidobacteria can produce while clostridia consume it. behavioral level, there no significant differences groups months. However, group had significantly lower MSEL scores group. Taken together, present results reveal early life alterations gut composition functionality ASD. These changes occur before any impairments be detected, supporting possible role for emerging variability later

Language: Английский

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Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 549 - 549

Published: Feb. 16, 2024

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in pathogenesis ASD. Research indicates abnormal composition gut microbiome potential involvement bacterial molecules neuroinflammation brain development disruptions. Concurrently, attention directed towards short-chain fatty acids (SCFAs) intestinal tightness. This comprehensive review emphasizes impact maternal microbiota changes on autism children, especially considering immune activation (MIA). The following paper evaluates birth route colonization child with bacteria first weeks life. Furthermore, it explores pro-inflammatory cytokines, such as IL-6 IL-17a mother’s obesity potentially environmental factors purpose this to advance our understanding ASD pathogenesis, while also searching for positive implications latest therapies, probiotics, prebiotics or fecal transplantation, targeting reducing inflammation. aims provide valuable insights that could instruct future studies treatments individuals affected

Language: Английский

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Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 101409 - 101409

Published: Feb. 1, 2024

Emerging evidence suggests autism spectrum disorder (ASD) is associated with altered gut bacteria. However, less known about the viral community and its role in shaping microbiota neurodevelopmental disorders. Herein, we perform a metagenomic analysis of gut-DNA viruses 60 children ASD 64 age- gender-matched typically developing to investigate effect virome on host bacteria ASD. composition accompanied by enrichment Clostridium phage, Bacillus Enterobacteria phage. These ASD-enriched phages are largely disrupted ecology Importantly, changes interplay between bacteriome seen may influence encoding capacity microbial pathways for neuroactive metabolite biosynthesis. findings suggest an impaired bacteriome-virome ASD, which sheds light importance bacteriophages pathogenesis development therapeutics

Language: Английский

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Multi-angle meta-analysis of the gut microbiome in Autism Spectrum Disorder: a step toward understanding patient subgroups

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Oct. 11, 2022

Abstract Observational studies have shown that the composition of human gut microbiome in children diagnosed with Autism Spectrum Disorder (ASD) differs significantly from their neurotypical (NT) counterparts. Thus far, reported ASD-specific signatures been inconsistent. To uncover reproducible signatures, we compiled 10 publicly available raw amplicon and metagenomic sequencing datasets alongside new data generated an internal cohort (the largest ASD to date), unified them standardized pre-processing methods, conducted a comprehensive meta-analysis all taxa variables detected across multiple studies. By screening metadata test associations between 52 patient subsets datasets, determined differentially abundant versus NT were dependent upon age, sex, bowel function, thus marking these as potential confounders case–control Several taxa, including strains Bacteroides stercoris t__190463 Clostridium M bolteae t__180407, species Granulicatella elegans Massilioclostridium coli , exhibited differential abundance compared only after subjects dysfunction removed. Adjusting for sex function resulted adding or removing ASD-diagnosed individuals, emphasizing importance collecting controlling metadata. We performed (n = 690) most systematic analysis date. Our study demonstrated accounting confounding when designing statistical comparative analyses ASD- NT-associated bacterial profiles. Mitigating identified robust microbial cohorts, signifying factors Such will advance understanding different groups deliver appropriate therapeutics by identifying traits germane specific phenotype.

Language: Английский

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Alteration of the gut microbiota profile in children with autism spectrum disorder in China

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 13, 2024

Background Autism spectrum disorder (ASD) is associated with alterations in the gut microbiome. However, there are few studies on microbiota of children ASD China, and a lack consensus changes bacterial species. Purpose Methods We used 16S rRNA sequencing to analyze (2 12 years), HC years). Results Our findings showed that α-diversity, composition, relative abundance group were significantly different from those groups. Compared group, α-diversity was decreased. At genus level, g_Faecalibacterium, g_Blautia, g_Eubacterium_eligens_group, g_Parasutterella, g_Lachnospiraceae_NK4A136_group g_Veillonella increased than groups, while g_Prevotella 9 g_Agathobacter decreased In addition, KEGG pathway analysis microbial functional abnormalities patients mainly concentrated metabolic pathways related fatty acid, amino acid metabolism aromatic compound metabolism, partially involved neurotransmitter metabolism. Conclusion This study revealed characteristics Chinese provided further evidence dysbiosis ASD.

Language: Английский

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