Role of oxidative stress in depression

Drug Discovery Today, Journal Year: 2020, Volume and Issue: 25(7), P. 1270 - 1276

Published: May 8, 2020

Language: Английский

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Role of Interleukin-6 in Depressive Disorder

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 2194 - 2194

Published: March 22, 2020

Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence suicide. Evidence from animal as well clinical studies have indicated that peripheral or central cytokine interleukin-6 (IL-6) levels play important role in stress reaction disorder, especially physical disorders comorbid with depression. Increased release IL-6 MDD has been found to be factor associated prognosis therapeutic response, may affect wide range symptomatology. However, study results IL6 genetic effects are controversial. activity cause depression through activation hypothalamic-pituitary-adrenal axis influence neurotransmitter metabolism. The neuroinflammation pathogenesis created new perspective combining blood other depression-related help classify biological subtypes, allow physicians identify optimal treatment for patients. To modulate by IL-6-related agents, current antidepressive herb medication, pre-/probiotics non-pharmacological interventions hold great promise patients inflammatory features.

Language: Английский

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Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 4, 2020

Centella asiatica (also known as (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which mainly used in Southeast Asian countries. This study aimed to summarize the effects of C. and its main components on neurological diseases, endocrine skin cardiovascular gastrointestinal immune gynecological well potential molecular mechanisms, pathological mechanism these diseases based changes at level. The results showed that triterpenoids had beneficial were confirmed through clinical studies. They exhibited anti-inflammatory, anti-oxidative stress, anti-apoptotic effects, improvement mitochondrial function. However, further studies are urgently required due low level evidence lack patients.

Language: Английский

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Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression

Brain Behavior and Immunity, Journal Year: 2020, Volume and Issue: 92, P. 10 - 24

Published: Nov. 10, 2020

Language: Английский

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Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of Alzheimer s Disease, Journal Year: 2020, Volume and Issue: 77(1), P. 139 - 147

Published: July 3, 2020

Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such mild cognitive impairment (MCI) dementia.We aimed to test the effect probiotic strain, Bifidobacterium breve A1 (MCC1274), restore cognition in physically healthy, suspected MCI population.In this randomized, double-blind, placebo-controlled trial, 80 healthy older adults suffering from were divided into two even groups receive once daily either (B. A1, 2×1010 CFU) or placebo 16 weeks using computer-generated algorithm. Cognitive functions assessed by Repeatable Battery Assessment Neuropsychological Status (RBANS) Japanese version Screen (JMCIS) tests before after study primary secondary endpoints, respectively.79 participants completed study, no adverse events observed. RBANS total score was significantly improved group compared (mean between-group difference 11.3 [95% CI 6.7 15.8]; p < 0.0001) consumption, particular significant improvement domain scores immediate memory, visuospatial/constructional, delayed memory (p 0.0001), both intention-to-treat (ITT) analysis per-protocol (PP) analysis. JMCIS also versus ITT = 0.052) PP 0.036).Study results indicate B. is safe effective approach improving subjects.

Language: Английский

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The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 1, 2022

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's disease (AD PD) that includes the highly controversial approval of Aβ-targeting antibody aducanumab AD. Hence, still an unmet need a neuroprotective drug in both AD PD. Type 2 diabetes risk factor Glucagon-like peptide 1 (GLP-1) hormone growth has shown effects preclinical studies, success GLP-1 mimetics phase II clinical trials PD raised new hope. are currently on market as treatments type diabetes. analogs safe, well tolerated, resistant to desensitization characterized clinic. Herein, we review existing evidence illustrate pathways induced following GLP-1R activation neurons, microglia astrocytes. The latter include synaptic protection, improvements cognition, learning motor function, amyloid pathology-ameliorating properties (Aβ, Tau, α-synuclein), suppression Ca

Language: Английский

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Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106099 - 106099

Published: Jan. 26, 2022

Language: Английский

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Neuroinflammation: A Potential Risk for Dementia

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 616 - 616

Published: Jan. 6, 2022

Dementia is a neurodegenerative condition that considered major factor contributing to cognitive decline reduces independent function. Pathophysiological pathways are not well defined for diseases such as dementia; however, published evidence has shown the role of numerous inflammatory processes in brain toward their pathology. Microglia central nervous system (CNS) principal components brain’s immune defence and can detect harmful or external pathogens. When stimulated, cells trigger neuroinflammatory responses by releasing proinflammatory chemokines, cytokines, reactive oxygen species, nitrogen species order preserve cell’s microenvironment. These markers include cytokines IL-1, IL-6, TNFα chemokines CCR3 CCL2 CCR5. Microglial may produce prolonged response that, some circumstances, indicated promotion diseases. The present review focused on involvement microglial cell activation throughout conditions link between dementia.

Language: Английский

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Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

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JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Nov. 8, 2023

Abstract The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological pathological processes such inflammation stress. Dysregulation this can lead to severe immunodeficiencies malignancies, its role extends neurotransduction pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological inflammatory disorders, their application has generally been limited diseases with similar pathogenic features. Despite the modest expression of JAK-STAT CNS, it is crucial for functions cortex, hippocampus, cerebellum, making relevant conditions like Parkinson's disease other neuroinflammatory disorders. Furthermore, influence on serotonin receptors phospholipase C implications stress mood This review expands understanding JAK-STAT, moving beyond traditional contexts explore stress-related disorders CNS function. Recent findings, effectiveness Jakinibs chronic rheumatoid arthritis, expand therapeutic applicability. Advances isoform-specific inhibitors, including filgotinib upadacitinib, promise greater specificity fewer off-target effects. Combination therapies, involving monoclonal antibodies, aiming enhance efficacy also give great hope. Overall, bridges gap between basic science clinical application, elucidating complex human health guiding future interventions. Graphical

Language: Английский

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