Russian Journal of Evidence-Based Gastroenterology, Journal Year: 2024, Volume and Issue: 13(4), P. 40 - 40
Published: Jan. 1, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.
Language: Английский
Citations
1
Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1425 - 1432
Published: April 29, 2024
Background & Aims Steatotic liver disease (SLD) is often detected in health examinations. However, although individuals with metabolic dysfunction-associated SLD (MASLD) may have decreased bone mineral density (BMD), the specific risk factors remain unclarified. The objective of this study was to identify associated BMD patients MASLD. Methods Individuals who underwent abdominal ultrasonography and measurements at our healthcare center were included. calcaneus assessed using an AOS-10SA densitometer. Decreased defined as a T-score below -1.0 SD or administration osteoporosis treatment. diagnosed based on ultrasonographic criteria. Results A total 1,410 median age 52 years. Multivariate analysis logistic regression model revealed that independent predictors low body mass index (BMI) small waist circumference (odds ratio (OR): 0.48, 95% confidence interval (CI): 0.34–0.67), hypertriglyceridemia (OR: 1.29, CI: 1.00–1.65), weak grip strength 0.98, 0.97–1.00). Subgroup analyses aged 50 years older, men, FIB-4 1.3 greater absence high BMI large BMD. subgroup men weaker Conclusion present suggested several potential for abovementioned should be encouraged undergo measurement from perspective preventive medicine.
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Dec. 4, 2023
Background Existing evidence on the associations of liver steatosis and fibrosis with bone mineral density (BMD) risk osteopenia/osteoporosis was limited conflicting results. We aimed to evaluate metabolic dysfunction-associated fatty disease (MAFLD) hepatic BMD in type 2 diabetes mellitus (T2DM) patients. Methods Baseline information an ongoing cohort 249 T2DM patients Xiamen, China analyzed. MAFLD defined as presence [diagnosed by either ultrasonography scanning or index (FLI) score >60] for measured using dual-energy x-ray absorptiometry at total lumbar (L2–4), femur neck (FN), hip (TH) categorized normal (T ≥ −1.0), osteopenia (−2.5 < T osteoporosis ≤ −2.5) according its minimum T-score. Results Among patients, prevalence rates MAFLD, osteopenia, were 57.8%, 50.6%, 17.7%, respectively. Patients had significantly higher T-scores L2–4, FN, TH well lower than without MAFLD. Hepatic indices, including FLI score, (FLI 60 scanning), positively associated all T-scores, while FIB-4 but not NAFLD (NFS), negatively T-scores. decreased unadjusted odds ratios (ORs) (95% CI) 0.565 (0.324–0.987) 0.434 (0.224–0.843) (both p -values 0.05), As fibrosis, NFS, elevated OR per SD increase 1.446 (1.080–1.936, -value = 0.013). Adjusting potential confounding variables, especially body mass index, multivariable regression analyses, indices statistically significant. Conclusion independent obesity. Nevertheless, screening management still important prevention fracture
Language: Английский
Citations
12
Journal of Bone and Mineral Metabolism, Journal Year: 2024, Volume and Issue: 42(4), P. 399 - 412
Published: Feb. 1, 2024
Language: Английский
Citations
4
Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 206 - 221
Published: Feb. 17, 2024
Language: Английский
Citations
4
Journal of Obesity & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 33(2), P. 108 - 120
Published: May 14, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) has profound adverse effects on bone health and homeostasis. MASLD appears to be associated with changes in mineral density (BMD) fracture rate. However, the data are ambiguous conflicting. Although several studies have shown that children adolescents decreased BMD, prevalence of fragility fractures among scarce. In adults, increasing evidence suggests decreases BMD increases risk fractures, which due deterioration architecture addition a decrease BMD. Effects may also age- race-specific. does not seem increase but elderly men, especially those Asian origin. From mechanistic perspective, remodeling is continuous process between osteoblasts (bone-forming) osteoclasts (bone-resorbing), any imbalance resulting metabolic disease. individuals MASLD, loss anabolic insulin receptor signaling (insulin resistance) increased activator nuclear factor κB (RANK)/RANK ligand (proinflammatory cytokines) swings pendulum toward accelerated loss. These processes further complicated by concomitant presence obesity, type 2 diabetes mellitus, or sarcopenia MASLD. This study reviews current literature children/adolescents adults. review discusses pathomechanisms link fractures.
Language: Английский
Citations
4
Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 6, 2025
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 20, 2025
Environmental factors, or exposome, are non-negligible contributors to the occurrence and progression of metabolic dysfunction-associated fatty liver disease (MAFLD). Therefore, this environment-wide association study (EWAS) aimed investigate associations between multifarious environmental factors MAFLD among general adult population in United States. Eligible participants were obtained from National Health Nutrition Examination Survey 2005-2020 cycles. Survey-weighted multivariate logistic regression models constructed identify tentatively validate MAFLD-associated factors. The least absolute shrinkage selection operator (LASSO) was conducted validated with stronger MAFLD. Moreover, importance, discrimination power, correlation patterns, subgroup-specific differences, survey cycle heterogeneity identified further examined by multiple statistical strategies. A total 14,416 included EWAS. Among 511 candidate 167 validated, 45 preserved after LASSO evaluation. In study, most previously known replicated reduced bias, several poorly studied discovered, for example, upper leg length, access care, mid-upper arm circumference, trabecular bone score. Their ability, pairwise correlations, subgroup variations, across cycles systematically rigorously evaluated. This EWAS comprehensively explored a panoramic perspective. findings may provide clues understanding promote early prevention risk prediction strategies future.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 6, 2024
Abstract Background Chronic liver diseases constitute a major global public health burden, posing substantial threat to patients’ daily lives and even survival due the potential development of musculoskeletal disorders. Although relationship between chronic disorders has received extensive attention, their causal not been comprehensively systematically investigated. Methods This study aimed assess relationships viral hepatitis, primary biliary cholangitis, sclerosing cholangitis (PSC), cirrhosis, hepatocellular carcinoma (HCC) with osteoporosis, osteoarthritis, sarcopenia through bidirectional Mendelian randomization (MR) research. The traits related osteoporosis osteoarthritis included both overall site-specific phenotypes, linked involved indicators muscle mass function. Random-effect inverse-variance weighted (IVW), median, MR-Egger, Causal Analysis Using Summary Effect Estimates were used evaluate effects, IVW being main analysis method. To enhance robustness, sensitivity analyses performed using Cochran’s Q test, MR-Egger intercept, MR-PRESSO funnel plots, leave-one-out analyses, latent variable model. Results forward MR indicated that PSC can reduce forearm bone mineral density (beta = − 0.0454, 95% CI 0.0798 0.0110; P 0.0098) increase risk (OR 1.012, 1.002–1.022; 0.0247), while HCC decrease grip strength 0.0053, 0.008 0.0025; 0.0002). reverse did find significant effects on diseases. Additionally, no heterogeneity or pleiotropy was detected. Conclusions These findings corroborate as well impact sarcopenia. Thus, implementation comprehensive preventive measures is imperative for patients mitigate disorders, ultimately improving quality life.
Language: Английский
Citations
3
Osteoporosis International, Journal Year: 2024, Volume and Issue: 35(12), P. 2087 - 2098
Published: Aug. 13, 2024
Language: Английский
Citations
3