Visual looming is a primitive for human emotion DOI Creative Commons
Monica K. Thieu, Vladislav Ayzenberg, Stella F. Lourenco

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109886 - 109886

Published: May 3, 2024

The neural computations for looming detection are strikingly similar across species. In mammals, information about approaching threats is conveyed from the retina to midbrain superior colliculus, where approach variables computed enable defensive behavior. Although neuroscientific theories posit that representations contribute emotion through connectivity with distributed brain systems, it remains unknown whether a computational system can predict both behavior and phenomenal experience in humans. Here, we show shallow convolutional network based on

Language: Английский

Deficiency of histamine H2 receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention DOI

Dadao An,

Yi You, Qianyi Ma

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines DOI Creative Commons
Chen Chen, Yuanming Liu, Jianhua Cang

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112194 - 112194

Published: March 11, 2025

Recent studies have revealed diverse neuron types in the superior colliculus (SC), a midbrain structure critical for sensorimotor transformation. Here, as an important step toward studying function of these subtypes, we characterize 10 transgenic mouse lines based on recently published molecular atlas superficial SC. We show that Cre or fluorescence expression some corresponds specifically to certain transcriptomic types. These include two GENSAT been used target morphological cell SC and three knockin lines. In contrast, such correspondence is not seen other tested mice. Importantly, pattern marker genes all highly consistent with atlas. Together, our support correlation between types, identify useful targeting genetically, demonstrate validity single-cell transcriptomics data.

Language: Английский

Citations

1
A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus DOI Creative Commons
Guanglei Hu,

Ailin Chen,

Jingjing Ye

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(1), P. 113667 - 113667

Published: Jan. 1, 2024

Detecting visual features in the environment is crucial for animals' survival. The superior colliculus (SC) implicated motion detection and processing, whereas how SC integrates inputs from two eyes remains unclear. Using vivo electrophysiology, we show that mouse contains many binocular neurons display robust ocular dominance (OD) plasticity a critical period during early development, which similar to, but not dependent on, primary cortex. NR2A- NR2B-containing N-methyl-D-aspartate (NMDA) receptors play an essential role regulation of plasticity. Blocking NMDA can largely prevent impairment predatory hunting caused by monocular deprivation, indicating maintaining binocularity required efficient behavior. Together, our studies reveal existence function OD SC, broadens understanding development subcortical circuitry relating to hunting.

Language: Английский

Citations

6
Genetically defined neuron types underlying visuomotor transformation in the superior colliculus DOI
Jianhua Cang, Chen Chen,

Chuiwen Li

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

6
Norepinephrine system at the interface of attention and reward DOI
Yuxiao Zhang, Yan Chen,

Yushi Xin

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 125, P. 110751 - 110751

Published: March 16, 2023

Language: Английский

Citations

15
Bio-Inspired Design of Superconducting Spiking Neuron and Synapse DOI Creative Commons
Andrey E. Schegolev, N. V. Klenov, Georgy I. Gubochkin

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(14), P. 2101 - 2101

Published: July 19, 2023

The imitative modelling of processes in the brain living beings is an ambitious task. However, advances complexity existing hardware models are limited by their low speed and high energy consumption. A superconducting circuit with Josephson junctions closely mimics neuronal membrane channels involved operation sodium-potassium pump. dynamic such a system characterised duration picoseconds level attojoules. In this work, two biological neuron studied. New modes identified, including so-called bursting mode, which plays important role neural networks. possibility switching between different situ shown, providing control system. synaptic connection that short-term potentiation synapse developed demonstrated. Finally, simplest two-neuron chain comprising proposed bio-inspired components simulated, prospects biosimilars briefly discussed.

Language: Английский

Citations

12
Disentangling the identity of the zona incerta: a review of the known connections and latest implications DOI Creative Commons

Giulia Arena,

Fabrizio Londei, Francesco Ceccarelli

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102140 - 102140

Published: Nov. 24, 2023

The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically mixed neurons, juxtaposed to the main ascending and descending bundles. extreme neurochemical diversity that characterizes this area, together with diffuseness of its connections entire neuraxis hard-to-reach positioning in brain caused ZI keep halo mystery for over century. However, last decades, rich albeit fragmentary body knowledge regarding both incertal anatomical functional implications has been built mostly based on rodent studies lack cohesion makes difficult depict an integrated, exhaustive picture roles. This review aims provide unified resource summarizes current profile interactions rodents non-human primates significance connections, highlighting aspects still unbeknown research.

Language: Английский

Citations

12
Neural Circuit Mechanisms Involved in Animals’ Detection of and Response to Visual Threats DOI
Qiwen Wu, Yifeng Zhang

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(6), P. 994 - 1008

Published: Jan. 25, 2023

Language: Английский

Citations

11
Pathway-specific inputs to the superior colliculus support flexible responses to visual threat DOI Creative Commons
Chen Li, Norma K. Kühn, Ilayda Alkislar

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(35)

Published: Aug. 30, 2023

Behavioral flexibility requires directing feedforward sensory information to appropriate targets. In the superior colliculus, divergent outputs orchestrate different responses visual threats, but circuit organization enabling flexible routing of remains unknown. To determine this structure, we focused on inhibitory projection (Gad2) neurons. Trans-synaptic tracing and neuronal recordings revealed that Gad2 neurons projecting lateral geniculate nucleus (LGN) parabigeminal (PBG) form two separate populations, each receiving a set non-retinal inputs. Inhibiting LGN- or PBG-projecting resulted in opposing effects behavior; increasing freezing escape probability looming, respectively. Optogenetic activation selected inputs cells predictably regulated threat. These data suggest projection-specific sampling brain-wide provides design principle enables be selectively routed produce context-specific behavior.

Language: Английский

Citations

11
Characterization of auditory responsive neurons in the mouse superior colliculus to naturalistic sounds DOI Creative Commons
Yufei Si, Shinya Ito, A. M. Litke

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Locating the source of a specific sound in complex environment and determining its saliency is critical for survival. The superior colliculus (SC), sensorimotor midbrain structure, plays an important role localization has been shown to have topographic map auditory space range species. In mice, previous studies using broadband white noise stimuli found that neurons use high-frequency monaural spectral cues interaural level differences (ILDs) compute spatially restricted receptive fields (RFs), these RFs are organized topographically along azimuth. However, naturalistic environment, animal encounters may rich components; however, sources can still be localized efficiently. It remains unknown whether how SC respond sounds and, turn, RF. Here, we show results from large-scale vivo physiological recordings response noise, ultrasonic pup calls chirps. We find mouse with distinct temporal patterns spatial preference predominantly at ∼60 degrees contralateral addition, categorized based on their spectrotemporal field demonstrated there least 4 subtypes responsive neurons. Significance Statement (SC) receives visual information used localize objects. While organization composition visually well described, much less known about types properties presented calls, chirp mice while recording Analysis neuronal responses defines classes also stimuli, mainly occur when side but not front animal. These lead hypothesis different strategies depending source.

Language: Английский

Citations

0