Emergent Aspects of the Integration of Sensory and Motor Functions

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 162 - 162

Published: Feb. 7, 2025

This article delves into the intricate mechanisms underlying sensory integration in executive control of movement, encompassing ideomotor activity, predictive capabilities, and motor systems. It examines interplay between functions, highlighting role cortical subcortical regions central nervous system enhancing environmental interaction. The acquisition skills, procedural memory, representation actions brain are discussed emphasizing significance mental imagery training function. development this aspect sensorimotor can help to advance our understanding interactions control, mechanisms, consciousness. Bridging theoretical insights with practical applications, it sets stage for future innovations clinical rehabilitation, assistive technology, education. ongoing exploration these domains promises uncover new pathways human capability well-being.

Language: Английский

---

Accessing genetically defined cell types in the Superior Colliculus with transgenic mouse lines

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112194 - 112194

Published: March 11, 2025

Recent studies have revealed diverse neuron types in the superior colliculus (SC), a midbrain structure critical for sensorimotor transformation. Here, as an important step toward studying function of these subtypes, we characterize 10 transgenic mouse lines based on recently published molecular atlas superficial SC. We show that Cre or fluorescence expression some corresponds specifically to certain transcriptomic types. These include two GENSAT been used target morphological cell SC and three knockin lines. In contrast, such correspondence is not seen other tested mice. Importantly, pattern marker genes all highly consistent with atlas. Together, our support correlation between types, identify useful targeting genetically, demonstrate validity single-cell transcriptomics data.

Language: Английский

---

Deficiency of histamine H2 receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

The superior colliculus

Current Biology, Journal Year: 2025, Volume and Issue: 35(5), P. R164 - R168

Published: March 1, 2025

Language: Английский

---

Norepinephrine system at the interface of attention and reward

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 125, P. 110751 - 110751

Published: March 16, 2023

Language: Английский

---

Disentangling the identity of the zona incerta: a review of the known connections and latest implications

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102140 - 102140

Published: Nov. 24, 2023

The zona incerta (ZI) is a subthalamic region composed by loosely packed neurochemically mixed neurons, juxtaposed to the main ascending and descending bundles. extreme neurochemical diversity that characterizes this area, together with diffuseness of its connections entire neuraxis hard-to-reach positioning in brain caused ZI keep halo mystery for over century. However, last decades, rich albeit fragmentary body knowledge regarding both incertal anatomical functional implications has been built mostly based on rodent studies lack cohesion makes difficult depict an integrated, exhaustive picture roles. This review aims provide unified resource summarizes current profile interactions rodents non-human primates significance connections, highlighting aspects still unbeknown research.

Language: Английский

---

A developmental critical period for ocular dominance plasticity of binocular neurons in mouse superior colliculus

Cell Reports, Journal Year: 2024, Volume and Issue: 43(1), P. 113667 - 113667

Published: Jan. 1, 2024

Detecting visual features in the environment is crucial for animals' survival. The superior colliculus (SC) implicated motion detection and processing, whereas how SC integrates inputs from two eyes remains unclear. Using vivo electrophysiology, we show that mouse contains many binocular neurons display robust ocular dominance (OD) plasticity a critical period during early development, which similar to, but not dependent on, primary cortex. NR2A- NR2B-containing N-methyl-D-aspartate (NMDA) receptors play an essential role regulation of plasticity. Blocking NMDA can largely prevent impairment predatory hunting caused by monocular deprivation, indicating maintaining binocularity required efficient behavior. Together, our studies reveal existence function OD SC, broadens understanding development subcortical circuitry relating to hunting.

Language: Английский

---

Genetically defined neuron types underlying visuomotor transformation in the superior colliculus

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

---

Bio-Inspired Design of Superconducting Spiking Neuron and Synapse

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(14), P. 2101 - 2101

Published: July 19, 2023

The imitative modelling of processes in the brain living beings is an ambitious task. However, advances complexity existing hardware models are limited by their low speed and high energy consumption. A superconducting circuit with Josephson junctions closely mimics neuronal membrane channels involved operation sodium-potassium pump. dynamic such a system characterised duration picoseconds level attojoules. In this work, two biological neuron studied. New modes identified, including so-called bursting mode, which plays important role neural networks. possibility switching between different situ shown, providing control system. synaptic connection that short-term potentiation synapse developed demonstrated. Finally, simplest two-neuron chain comprising proposed bio-inspired components simulated, prospects biosimilars briefly discussed.

Language: Английский

---

Pathway-specific inputs to the superior colliculus support flexible responses to visual threat

Science Advances, Journal Year: 2023, Volume and Issue: 9(35)

Published: Aug. 30, 2023

Behavioral flexibility requires directing feedforward sensory information to appropriate targets. In the superior colliculus, divergent outputs orchestrate different responses visual threats, but circuit organization enabling flexible routing of remains unknown. To determine this structure, we focused on inhibitory projection (Gad2) neurons. Trans-synaptic tracing and neuronal recordings revealed that Gad2 neurons projecting lateral geniculate nucleus (LGN) parabigeminal (PBG) form two separate populations, each receiving a set non-retinal inputs. Inhibiting LGN- or PBG-projecting resulted in opposing effects behavior; increasing freezing escape probability looming, respectively. Optogenetic activation selected inputs cells predictably regulated threat. These data suggest projection-specific sampling brain-wide provides design principle enables be selectively routed produce context-specific behavior.

Language: Английский

---