Guidelines derived from biomineralized tissues for design and construction of high-performance biomimetic materials: from weak to strong

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(9), P. 4490 - 4606

Published: Jan. 1, 2024

This review discusses recent advances, challenges, future research directions and perspectives in biomineralized tissues, providing in-depth insights into derived guidelines for design preparation of high-performance biomimetic materials.

Language: Английский

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Photo-responsive polydopamine nanoenzyme microneedles with oxidative stress regulation ability for atopic dermatitis treatment

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102241 - 102241

Published: March 28, 2024

Language: Английский

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Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract Physical cues like morphology, light, electric signal, mechanic magnetic and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation regeneration. As physical stimulation applied directly the cannot focused on defect area regulate cell behaviors fate situ, this limits efficiency of precise Biomaterials‐mediated situ cues, an effective strategy combining synergistic effect materials themselves, are put forward studied widely repair efficiently precisely. Different types provide different choices better satisfy requirements targeted repair. In review, recent research about biomaterials‐mediated accelerating osteogenesis vitro promoting formation vivo is introduced. Meanwhile, corresponding possible mechanisms various regulating responses also discussed. This review provides useful enlightening guidance utilization intrinsically properties functional achieve efficient regeneration, leading design construction smart biomaterials practical applications, eventually clinical translation.

Language: Английский

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Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 1, 2023

Abstract Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue engineering, clinical transformation of these remained a big challenge because difficulty simulating native organs/tissues’ microenvironment. As kind natural tissue-derived biomaterials, decellularized extracellular matrix (dECM)-based have gained attention due to their unique biomimetic properties, providing specific microenvironment suitable promoting cell proliferation, migration, attachment and regulating differentiation. The medical applications dECM-based addressed critical challenges, including poor mechanical strength insufficient stability. For reconstruction damaged tissues or organs, different types composite platforms been designed mimic microenvironment, by integrating with polymer or/and syntenic adding bioactive factors. In this review, we summarized research progress regenerative medicine, highlighting challenges future perspectives related application materials.

Language: Английский

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Ultrasound-driven electrical stimulation based on 3D hierarchical porous piezoelectric nanofiber-aerogel scaffold promotes bone defect repair

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 144305 - 144305

Published: June 22, 2023

Language: Английский

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Application of Gelatin-Based Composites in Bone Tissue Engineering

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36258 - e36258

Published: Aug. 1, 2024

Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.

Language: Английский

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Abundant nucleation sites-available liquid crystal hydrogel mimics bone ECM mineralization to boost osteogenesis

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 275, P. 111340 - 111340

Published: Feb. 27, 2024

Language: Английский

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Highly Stretchable, Transparent, and Adhesive Double-Network Hydrogel Dressings Tailored with Fish Gelatin and Glycyrrhizic Acid for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(36), P. 42304 - 42316

Published: Aug. 30, 2023

It remains challenging to fabricate highly stretchable and adhesive hydrogel dressings for wound healing using simple, safe, green methods. Herein, inspired by the main components of snail mucus, a fully physical double-network (DN) dressing composed fish gelatin (FGel) glycyrrhizic acid (GL) was fabricated, in which FGel provided protein scaffold mimic mucus proteins, while GL mimicked adhesion bioactivity because its abundant carboxyl hydroxyl groups intrinsic immunomodulatory activity. As expected, obtained FGel/GL exhibited outstanding mechanical performances (flexibility, stretchability, ability, removability), high transparency, good antifreezing properties. More importantly, they also possessed excellent biocompatibility, cell migration, angiogenesis ability vitro experiments. Finally, animal experiments vivo indicated that significantly promoted full-thickness healing, including promoting granulation tissue formation, collagen deposition, skin inhibiting inflammatory response. All these findings have great potential applications clinical treatment healing.

Language: Английский

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2-N, 6-O sulfated chitosan evokes periosteal stem cells for bone regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 282 - 297

Published: Jan. 3, 2024

Musculoskeletal injuries and bone defects represent a significant clinical challenge, necessitating innovative approaches for effective tissue regeneration. In this study, we investigated the potential of harnessing periosteal stem cells (PSCs) glycosaminoglycan (GAG)-mimicking materials

Language: Английский

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Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 1, 2024

Abstract Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, microenvironment bone was exploited to develop multifunctional nanocarrier capable and promoting regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin, BP Avi ) were combined with biotin-modified Icaritin (ICT-Biotin, ICT Bio synthesize (ICT)-loaded (BP ). then coated macrophage membranes (MMs) obtain MMs-camouflaged (M@BP Herein, MMs allowed target area, accelerated the release phosphate ions (PO 4 3− when exposed NIR irradiation. PO recruited calcium (Ca 2+ from produce Ca 3 2 , increased expression osteogenesis-related proteins. Additionally, M@BP decrease M1 polarization pro-inflammatory factors promote osteogenesis. According results, provided growth factor repair material, modulated microenvironment, activated signaling pathways PTT could significantly enhance effects. This strategy not only offers solution challenging problem drug-targeted delivery also expands biomedical applications nanocarriers. Graphical

Language: Английский

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