Progress in the treatment of Alzheimer's Disease based on nanosized Traditional Chinese Medicine DOI
Dan Song, Jieyu Zhang, Xuefeng Hu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Traditional Chinese medicine (TCM) has been employed for centuries in treating and managing Alzheimer's disease (AD). However, their effective delivery to target sites can be a major challenge. This is due poor water solubility, low bioavailability, potential toxicity. Furthermore, the blood-brain barrier (BBB) obstacle TCM delivery, significantly reducing efficacy. Advancements nanotechnology its applications (nano-TCM) deliver active ingredients or components of across BBB targeted brain area. review summarizes recent advances nanocarrier-based systems different types constituents AD, including terpenoids, polyphenols, alkaloids, flavonoids, quinones. Besides, main challenges opportunities future development these advanced nanocarriers are emphasized. In conclusion, this provides valuable insights guidance utilizing shape drug delivery.

Language: Английский

Aqueous Grown Quantum Dots with Robust Near-Infrared Fluorescence for Integrated Traumatic Brain Injury Diagnosis and Surgical Monitoring DOI
Mingxia Jiao, Xiaoqi Li, Hui Liu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19038 - 19053

Published: July 9, 2024

Surgical intervention is the most common first-line treatment for severe traumatic brain injuries (TBIs) associated with high intracranial pressure, while complexity of these surgical procedures often results in complications. Surgeons struggle to comprehensively evaluate TBI status, making it difficult select optimal strategy. Here, we introduce a fluorescence imaging-based technology that uses high-quality silver indium selenide-based quantum dots (QDs) integrated diagnosis and guidance. These engineered, poly(ethylene glycol)-capped QDs emit near-infrared region, are resistant phagocytosis, importantly, ultrastable after epitaxial growth an aluminum-doped zinc sulfide shell aqueous phase renders long-term light irradiation complex physiological environments. We found intravenous injection enabled both precise mouse model and, more comprehensive evaluation status before, during, operation distinguish from superficial hemorrhages, provide real-time monitoring secondary hemorrhage, guide decision on evacuation hematomas. This QD-based diagnostic system could ultimately complement existing clinical tools treating TBI, which may help surgeons improve patient outcomes avoid unnecessary procedures.

Language: Английский

Citations

5
Nanomaterial Technologies for Precision Diagnosis and Treatment of Brain Hemorrhage DOI
Peisen Zhang,

Y. Ran,

Lei Han

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123269 - 123269

Published: March 1, 2025

Language: Английский

Citations

0
Biomimetic Nanocomposites for Glioma Imaging and Therapy DOI

Siyu Chi,

Caixia Wang,

Zhihong Liu

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(31)

Published: March 28, 2024

Glioma, the most common primary brain tumor, is highly invasive and grows rapidly. As such, survival of glioma patients relatively short, highlighting vital importance timely diagnosis treatment glioma. However, blood barrier (BBB) non-targeting delivery systems contrast agents drugs greatly hinder effective imaging therapy. Fortunately, in recent years, investigators have constructed various biomimetic platforms utilizing exceptional advantages nanocomposites, such as immune evasion, homologous targeting ability, BBB penetrating to achieve efficient precise substances sites for improved treatment. In this concept, we present application these nanocomposites fluorescence (FI), magnetic resonance (MRI), multi-modal imaging, well chemotherapy, phototherapy, combined therapy Lastly, provide our perspective on research field.

Language: Английский

Citations

2
Biomedical applications of stimuli‐responsive nanomaterials DOI Creative Commons
Xiaojie Chen, Di Wu, Zhong Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.

Language: Английский

Citations

2
A novel method for the diagnosis of atherosclerosis based on nanotechnology DOI
Ying Yang,

Jiangpeng Pan,

Aifeng Wang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9144 - 9154

Published: Jan. 1, 2024

Cardiovascular disease (CVD) is a global health concern, presenting significant risks to human health. Atherosclerosis among the most prevalent CVD, impacting medium and large arteries in kidneys, brain, heart, other vital organs, as well lower limbs. As progresses, arterial obstruction can result heart attacks strokes. Therefore, patients with atherosclerosis should receive accurate diagnosis timely therapeutic intervention. With advancements nanomedicine, researchers have proposed new research strategies methods for imaging. This paper summarizes some current findings on use of nanomaterials diagnosing offers insights optimizing imaging applications future.

Language: Английский

Citations

1
Molecular imaging-guided diagnosis and treatment integration for brain diseases DOI

Donghu Yu,

Menghao Liu, Qihang Ding

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123021 - 123021

Published: Dec. 15, 2024

Language: Английский

Citations

1
Progress in the treatment of Alzheimer's Disease based on nanosized Traditional Chinese Medicine DOI
Dan Song, Jieyu Zhang, Xuefeng Hu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Traditional Chinese medicine (TCM) has been employed for centuries in treating and managing Alzheimer's disease (AD). However, their effective delivery to target sites can be a major challenge. This is due poor water solubility, low bioavailability, potential toxicity. Furthermore, the blood-brain barrier (BBB) obstacle TCM delivery, significantly reducing efficacy. Advancements nanotechnology its applications (nano-TCM) deliver active ingredients or components of across BBB targeted brain area. review summarizes recent advances nanocarrier-based systems different types constituents AD, including terpenoids, polyphenols, alkaloids, flavonoids, quinones. Besides, main challenges opportunities future development these advanced nanocarriers are emphasized. In conclusion, this provides valuable insights guidance utilizing shape drug delivery.

Language: Английский

Citations

0