Exploring the Chemopreventive Potential of Artemisia annua Methanolic Extract in Colorectal Cancer Induced by Azoxymethane in Mice DOI Creative Commons
Faris Alrumaihi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 34 - 34

Published: Dec. 31, 2024

Background/Objectives: Colorectal cancer (CRC) remains a major global health burden, necessitating innovative preventive approaches. Artemisia annua (A. annua), known for its extensive pharmacological properties, has shown potential in therapy. This study investigates the chemopreventive efficacy of methanolic extract A. (MEA) an azoxymethane (AOM)-induced murine model CRC, with focus on antioxidant, biomarker modulation, and pro-apoptotic activities. Methods: MEA was obtained via cold solvent extraction, yielding 39%, demonstrated potent vitro cytotoxicity against HCT116 RKO colon cell lines, IC50 values 20 µg/mL 15 µg/mL, respectively. Swiss albino mice were treated beginning two weeks before AOM induction, treatment continuing 21 weeks. Survival monitored 40 Key outcomes included serum levels (ADA, GGT, CD73, LDH), antioxidant enzyme activities (SOD, CAT, GPx1, MDA), reactive oxygen species (ROS) apoptosis histopathological evaluation. Results: significantly improved survival rates, reduced AOM-induced weight loss, modulated biomarkers, marked reductions ADA, LDH levels. Antioxidant defenses restored, as evidenced by increased SOD, GPx1 decreased MDA ROS reduced, colonic cells effectively induced. Histopathological analysis revealed substantial mitigation CRC-associated morphological abnormalities. Conclusions: exhibits robust demonstrating to reduce oxidative stress, modulate key induce CRC. These findings position promising natural candidate CRC prevention therapy, warranting further exploration clinical application.

Language: Английский

Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling DOI
Xia Yu,

Yixin Tang,

Zhixin Huang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 117, P. 111108 - 111108

Published: Feb. 16, 2024

Language: Английский

Citations

10
Regulation of 5-fluorouracil-induced intestinal damage by the interleukin-23/interleukin-22 axis in chemotherapy DOI

Yunning Han,

Jingping Xu,

Yuxuan Zhang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114044 - 114044

Published: Jan. 9, 2025

Language: Английский

Citations

0
Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option DOI
Chengu Niu, Jing Zhang, Patrick Okolo

et al.

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Citations

0
Senotherapeutic effect of Agrimonia pilosa Ledeb. in targeting senescent cells in naturally aged mice DOI

Tomomichi Watanabe,

Misato Yazaki,

Tomoaki Yazaki

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103903 - 103903

Published: March 14, 2024

Language: Английский

Citations

1
Artesunate Exerts Organ- and Tissue-Protective Effects by Regulating Oxidative Stress, Inflammation, Autophagy, Apoptosis, and Fibrosis: A Review of Evidence and Mechanisms DOI Creative Commons
Mingtao Zhu, Yu Wang,

Jianwei Han

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 686 - 686

Published: June 3, 2024

The human body comprises numerous organs and tissues operating in synchrony, it facilitates metabolism, circulation, overall organismal function. Consequently, the well-being of our significantly influences health. In recent years, research on protective effects artesunate (AS) various organ functions, including heart, liver, brain, lungs, kidneys, gastrointestinal tract, bones, others has witnessed significant advancements. Findings from vivo vitro studies suggest that AS may emerge as a newfound guardian against damage. Its mechanisms primarily entail inhibition inflammatory factors affect anti-fibrotic, anti-aging, immune-enhancing, modulation stem cells, apoptosis, metabolic homeostasis, autophagy properties. Moreover, is attracting high level interest because its obvious antioxidant activities, activation Nrf2 HO-1 signaling pathways, inhibiting release reactive oxygen species, interfering with expression genes proteins associated oxidative stress. This review comprehensively outlines strides made by alleviating injuries stemming causes protecting organs, aiming to serve reference for further in-depth utilization AS.

Language: Английский

Citations

1
Identification of Novel Protein Biomarkers and Drug Targets for Acne Vulgaris by Integrating Human Plasma Proteome with Genome-Wide Association Data DOI Creative Commons

Dongrui Xu,

Xiaoyi Yang, Wenjuan Wu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4431 - 4441

Published: July 1, 2024

Background: Despite the availability of numerous therapies, treatment acne vulgaris remains challenging. Novel drug targets for are still needed. Methods: We conducted a Mendelian randomization analysis to explore possible vulgaris. utilized summary statistics obtained from dataset vulgaris, including 399,413 individuals European ancestry. gathered genetic instruments 566 plasma proteins genome-wide association studies. In order strengthen findings randomization, various methods were employed, bidirectional analysis, Bayesian co-localization, phenotype scanning, and single-cell analysis. These facilitated identification reverse causality, search reported variant-trait associations, determination cell types that is primary source protein. Furthermore, using in deCODE cohort, we replication as an external validation. Results: At significance level Bonferroni (P < 8.83× 10 − 5 ), protein-acne pair was discovered through plasma, increasing TIMP4 (OR = 1.15; 95% CI, 1.09– 1.21; P 1.01× 7 ) increased risk The absence causality observed According co-localization shared same variant with (PPH4 0.93). replicated cohort 1.17; 1.10– 1.24; 1.48× ). Single-cell revealed predominantly detected myeloid cells blood, almost all skin tissue. Conclusion: integrative has direct influence on developing This implies protein could serve potential target development drugs aimed at treating Keywords: proteome, target, biomarker,

Language: Английский

Citations

1
Proteomic Analysis Identifies Multiple Mechanisms of 5-Fluorouracil-Induced Gut Mucositis in Mice DOI Open Access
Sergey M. Ivanov, Victor G. Zgoda,

Valeria A. Isakova

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 4025 - 4025

Published: Nov. 30, 2024

Damage of the gastrointestinal mucosa is a major side effect anticancer drug 5-fluorouracil (5-FU). Insight into molecular pathogenesis 5-FU-induced gut mucositis expected to justify strategies prophylaxis.

Language: Английский

Citations

1
Molecular Mechanisms of Plant Extracts in Protecting Aging Blood Vessels DOI Open Access
Yuxin Luo,

Zeru Zhang,

Weijian Zheng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2357 - 2357

Published: July 20, 2024

Plant Extracts (PE) are natural substances extracted from plants, rich in various bioactive components. Exploring the molecular mechanisms and interactions involved vascular protective effects of PE is beneficial for development further strategies to protect aging blood vessels. For this review, content was obtained scientific databases such as PubMed, China National Knowledge Infrastructure (CNKI), Google Scholar up July 2024, using search terms “Plant extracts”, “oxidative stress”, “vascular aging”, “endothelial dysfunction”, “ROS”, “inflammation”. This review highlighted protecting Through pathways scavenging reactive oxygen species, activating antioxidant signaling pathways, enhancing respiratory chain complex activity, inhibiting mitochondrial-reactive species generation, improving nitric oxide bioavailability, downregulating secretion inflammatory factors, sirtuins 1 Nrf2 it can improve structural functional changes caused by age-related oxidative stress, mitochondrial dysfunction, inflammation due aging, thereby reducing incidence cardiovascular diseases.

Language: Английский

Citations

0
Anti-tumor mechanism of artesunate DOI Creative Commons
Xiaoyu Fan, Yiming Yan, Yafei Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Artesunate (ART) is a classic antimalarial drug with high efficiency, low toxicity and tolerance. It has been shown to be safe good anti-tumor effect. Existing clinical studies have that the mechanisms of ART mainly include inducing apoptosis autophagy tumor cells, affecting microenvironment, regulating immune response, overcoming resistance, as well inhibiting cell proliferation, migration, invasion, angiogenesis. proven fight against lung cancer, hepatocarcinoma, lymphoma, multiple myeloma, leukemia, colorectal ovarian cervical malignant melanoma, oral squamous carcinoma, bladder prostate cancer other neoplasms. In this review, we highlight effects on various tumors an emphasis its mechanism, which helpful propose potential research directions expand application.

Language: Английский

Citations

0
Exploring the Chemopreventive Potential of Artemisia annua Methanolic Extract in Colorectal Cancer Induced by Azoxymethane in Mice DOI Creative Commons
Faris Alrumaihi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 34 - 34

Published: Dec. 31, 2024

Background/Objectives: Colorectal cancer (CRC) remains a major global health burden, necessitating innovative preventive approaches. Artemisia annua (A. annua), known for its extensive pharmacological properties, has shown potential in therapy. This study investigates the chemopreventive efficacy of methanolic extract A. (MEA) an azoxymethane (AOM)-induced murine model CRC, with focus on antioxidant, biomarker modulation, and pro-apoptotic activities. Methods: MEA was obtained via cold solvent extraction, yielding 39%, demonstrated potent vitro cytotoxicity against HCT116 RKO colon cell lines, IC50 values 20 µg/mL 15 µg/mL, respectively. Swiss albino mice were treated beginning two weeks before AOM induction, treatment continuing 21 weeks. Survival monitored 40 Key outcomes included serum levels (ADA, GGT, CD73, LDH), antioxidant enzyme activities (SOD, CAT, GPx1, MDA), reactive oxygen species (ROS) apoptosis histopathological evaluation. Results: significantly improved survival rates, reduced AOM-induced weight loss, modulated biomarkers, marked reductions ADA, LDH levels. Antioxidant defenses restored, as evidenced by increased SOD, GPx1 decreased MDA ROS reduced, colonic cells effectively induced. Histopathological analysis revealed substantial mitigation CRC-associated morphological abnormalities. Conclusions: exhibits robust demonstrating to reduce oxidative stress, modulate key induce CRC. These findings position promising natural candidate CRC prevention therapy, warranting further exploration clinical application.

Language: Английский

Citations

0