The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story DOI Creative Commons

Maria Skoufou,

Christina Tsigalou, Stergios Vradelis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 194 - 194

Published: Jan. 18, 2024

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.

Language: Английский

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review DOI Open Access
Babak Pakbin, Wolfram Manuel Brück, John W. A. Rossen

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 9922 - 9922

Published: Sept. 14, 2021

Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota humans animals. This harmless commensal organism can acquire a mixture comprehensive mobile genetic elements that contain genes encoding virulence factors, becoming an emerging human pathogen capable causing broad spectrum extraintestinal diseases. Nine definite enteric E. pathotypes have been well characterized, diseases ranging from various gastrointestinal disorders to urinary tract infections. These employ many factors effectors subverting functions host cells mediate their pathogenesis. review summarizes new developments in our understanding diverse associated with used by different pathogenic cause humans.

Language: Английский

Citations

194
Ruminococcus gnavus: friend or foe for human health DOI Creative Commons

Emmanuelle H. Crost,

Erika Coletto, Andrew Bell

et al.

FEMS Microbiology Reviews, Journal Year: 2023, Volume and Issue: 47(2)

Published: March 1, 2023

Abstract Ruminococcus gnavus was first identified in 1974 as a strict anaerobe the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With advent metagenomics, R. associated both positively negatively with an increasing number intestinal extraintestinal diseases from inflammatory bowel neurological disorders. This prompted renewed interest understanding adaptation mechanisms gut, molecular mediators affecting association health disease. From ca. 250 publications citing since 1990, 94% were published last 10 years. In this review, we describe biological characterization gnavus, occurrence infant adult microbiota factors influencing colonization gastrointestinal tract; also discuss current state our knowledge on role host We highlight gaps hypothesis that differential outcomes are strain niche specific.

Language: Английский

Citations

145
Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease DOI Open Access
Ángela Saéz, Raquel Gómez-Bris, Beatriz Herrero‐Fernández

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(14), P. 7618 - 7618

Published: July 16, 2021

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation unknown cause encompassing Crohn’s (CD) and ulcerative colitis (UC). IBD has been linked to genetic environmental factors, microbiota dysbiosis, exacerbated innate adaptive immunity epithelial barrier dysfunction. classically associated with gut accumulation proinflammatory Th1 Th17 cells accompanied by insufficient Treg numbers Tr1 immune suppression. T guide perpetuate constant hypersensitivity microbial antigens, tissue injury inflammation. Recent studies mucosal homeostasis suggest involvement lymphoid (ILCs). These lymphoid-origin are counterparts but lack the antigen receptors expressed on B cells. ILCs play important roles in first line antimicrobial defense contribute organ development, protection regeneration, maintaining balance between antipathogen commensal tolerance. Intestinal requires strict regulation quantity activity local ILC subpopulations. demonstrated that changes during development. A better understanding behavior gastrointestinal will provide valuable insights into new approaches treatment. This review summarizes recent research latest advances role IBD, particular emphasis interaction populations functions.

Language: Английский

Citations

134
Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics DOI Creative Commons
Quan Lu, Meifeng Yang, Yujie Liang

et al.

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 1825 - 1844

Published: March 1, 2022

Abstract: As a main digestive organ and an important immune organ, the intestine plays vital role in resisting invasion of potential pathogens into body. Intestinal dysfunction remains pathogenesis inflammatory bowel disease (IBD). In this review, we explained interactions among symbiotic flora, intestinal epithelial cells, system, clarified operating mechanism highlighted immunological IBD, with focus on development immunotherapy for IBD. addition, fibrosis is significant complication patients long-term reviewed involved fibrogenesis provided novel antifibrotic immunotherapies Keywords: disease, pathogenesis,

Language: Английский

Citations

110
Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: recent challenges and future recommendations DOI Creative Commons
Tariq Aziz, Nageen Hussain,

Zunaira Hameed

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 4, 2024

A healthy balanced diet is crucial in protecting the immune system against infections and diseases. Poor diets, such as Western diet, contribute to development of metabolic diseases, hypertension, obesity. Microbiota, primarily composed different microorganisms residing gastrointestinal tract (GIT), also play a significant role maintaining gut health. Polyphenols probiotics found fruits, vegetables, whole grains, legumes, nuts, seeds promote health support growth beneficial bacteria. Different types their categories, impact on are mentioned. The relationship between health, risk developing obesity, cardiovascular inflammatory diseases discussed this review article. rationale behind concludes future recommendations for reducing occurrence cardiometabolic other There need standardized research methods, long-term studies, translating scientific knowledge into practical dietary recommendations.

Language: Английский

Citations

85
Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties DOI Open Access
Antonio Pellegrino,

Gaetano Coppola,

Francesco Santopaolo

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1815 - 1815

Published: April 8, 2023

The gut microbiota plays a critical role in the modulation of host metabolism and immune response, its impairment has been implicated many gastrointestinal extraintestinal diseases. Current evidence shows well-documented A. muciniphila maintaining integrity intestinal barrier, modulating improving several metabolic pathways, making it key element pathogenesis human In this scenario, is most promising next-generation probiotic one first microbial species suitable for specific clinical use when compared with traditional probiotics. Further studies are needed to provide more accurate insight into mechanisms action better elucidate properties major areas, paving way integrated personalized therapeutic approach that finally makes our knowledge microbiota.

Language: Английский

Citations

43
Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota DOI
Yinhua Ni, Yi Zhang,

Liujie Zheng

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 324, P. 121699 - 121699

Published: April 14, 2023

Language: Английский

Citations

42
Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease DOI Creative Commons

Zhangpeng Shi,

Xiaohong Li,

Jufeng Chen

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 167 - 180

Published: Jan. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Language: Английский

Citations

24
Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system DOI Creative Commons

Linxian Zhao,

Tongbo Zhang,

Kai Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 18, 2024

Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as bowel disease (IBD) gastrointestinal tumors. As the king herbs, ginseng has exerted wide range pharmacological effects in various diseases. Especially, it been shown that ginsenosides have strong immunomodulatory anti-inflammatory abilities system. In this review, we summarized how extracts influence inflammation function, including regulating balance, modulating expression mediators cytokines, promoting mucosal wound healing, preventing colitis-associated colorectal cancer, recovering gut microbiota metabolism imbalance, alleviating antibiotic-induced diarrhea, relieving symptoms irritable syndrome. addition, specific experimental methods key control mechanisms are also briefly described.

Language: Английский

Citations

17
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease DOI Creative Commons

Salma Sultan,

Mohammed El‐Mowafy, Abdelaziz Elgaml

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 27, 2021

Inflammatory bowel diseases (IBD) are chronic medical disorders characterized by recurrent gastrointestinal inflammation. While the etiology of IBD is still unknown, pathogenesis disease results from perturbations in both gut microbiota and host immune system. Gut dysbiosis depleted diversity, reduced abundance short chain fatty acids (SCFAs) producers enriched proinflammatory microbes such as adherent/invasive E. coli H2S producers. This may contribute to inflammation through affecting either system or a metabolic pathway. The responses extensively discussed. In this review, we highlight main pathways that regulate host-microbiota interaction. We also discuss reported findings indicating microbial during has potential impact on colonocytes underlie progression. Moreover, present defectiveness adds symbiont will raise possibility associated with functional interactions, consequently modulates development. Finally, shed light possible therapeutic approaches targeting microbiome.

Language: Английский

Citations

88