Mosquitoes do not like bitter: new perspectives for biorational repellents DOI Open Access
Cláudio R. Lazzari, Isabel Ortega-Insaurralde,

Jérémy Esnault

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 23, 2023

Abstract Chemical repellents play a crucial role in personal protection, serving as essential elements reducing the transmission of vector-borne diseases. A biorational perspective that extends beyond olfactory system classical target may be promising direction to move. The taste provides reliable information regarding food quality, helping animals discriminate between nutritious and potentially harmful sources, often associated with bitter taste. Understanding how compounds affect feeding blood-sucking insects could unveil novel molecules potential reduce biting feeding. Here, we investigated impact two naturally occurring compounds, caffeine quinine, on decisions female Aedes aegypti mosquitoes at distinctive phases: (1) when mosquito explores substrate using external sensors (2) takes sip tastes it internal receptors. We assessed aversiveness through both an artificial condition (artificial feeder test) real host (arm-in-cage test). Our findings revealed different sensitivities sensory pathways responsible for detecting Ae. . Internal detectors exhibited responsiveness lower doses compared sensors. Quinine exerted more pronounced negative activity than caffeine. implications our are discussed context recognition practical protection.

Language: Английский

Structural basis for sugar perception by Drosophila gustatory receptors DOI
Demin Ma, Meiqin Hu, Xiaotong Yang

et al.

Science, Journal Year: 2024, Volume and Issue: 383(6685)

Published: Feb. 2, 2024

Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to encode different taste modalities, such as sweet and bitter. We report structures

Language: Английский

Citations

22
Avoiding cantharidin through ionotropic receptors DOI
Roshani Nhuchhen Pradhan, Bhanu Shrestha, Youngseok Lee

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 466, P. 133497 - 133497

Published: Jan. 11, 2024

Language: Английский

Citations

11
Molecular Basis of Hexanoic Acid Taste in Drosophila melanogaster DOI Open Access
Roshani Nhuchhen Pradhan, Bhanu Shrestha, Youngseok Lee

et al.

Molecules and Cells, Journal Year: 2023, Volume and Issue: 46(7), P. 451 - 460

Published: May 19, 2023

Animals generally prefer nutrients and avoid toxic harmful chemicals.Recent behavioral physiological studies have identified that sweet-sensing gustatory receptor neurons (GRNs) in Drosophila melanogaster mediate appetitive behaviors toward fatty acids.Sweet-sensing GRN activation requires the function of ionotropic receptors IR25a, IR56d, IR76b, as well GR64e.However, we reveal hexanoic acid (HA) is rather than nutritious to D. melanogaster.HA one major components fruit Morinda citrifolia (noni).Thus, analyzed responses noni acids, HA, via electrophysiology proboscis extension response (PER) assay.Electrophysiological tests show this reminiscent arginine-mediated neuronal responses.Here, determined a low concentration HA induced attraction, which was mediated by GRNs, high aversion, bitter-sensing GRNs.We also demonstrated elicits attraction mainly GR64d IR56d expressed but activates three (GR32a, GR33a, GR66a) GRNs.The mechanism sensing biphasic dose dependent manner.Furthermore, inhibit sugar-mediated like other bitter compounds.Taken together, discovered binary HA-sensing may be evolutionarily meaningful foraging niche insects.

Language: Английский

Citations

20
Mimicking evasive behavior in wavelength‐dependent reconfigurable phototransistors with ultralow power consumption DOI Creative Commons

He Shao,

Yueqing Li,

Jiefeng Chen

et al.

SmartMat, Journal Year: 2023, Volume and Issue: 5(4)

Published: June 28, 2023

Abstract Retinal‐inspired synaptic phototransistors, which integrate light signal detection, preprocessing, and memory functions, show promising applications in artificial vision sensors. In recent years, it has been reported to construct heterojunction phototransistors realize positive photoconductance (PPC) negative (NPC) modulations, thereby achieving visible infrared wavelength discrimination various visual functions. However, relatively little attention paid wavelength‐dependent switching reconfigurability between two states (PPC NPC), limiting further for complex simulations of biological Here, a mixed organic–inorganic phototransistor was constructed by integrating CsPbBr 3 nanoplates (NPLs) with strong blue‐light absorption poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) red‐light absorption. Compared the three‐dimensional (3D) structure nanocubes (NCs), two‐dimensional (2D) NPLs exhibited more efficient charge transfer P3HT. Based on individual optical properties heterojunction, device wavelength‐selective reconfigurable behavior PPC NPC. A low power consumption 0.053 fJ per event achieved, is comparable synapse. Finally, Drosophila 's evasive food under red blue can be successfully demonstrated. This work demonstrates future potential visuomorphic computing.

Language: Английский

Citations

20
Avoiding alkaline taste through ionotropic receptors DOI Creative Commons
Prakash Pandey,

Bhanu Shrestha,

Youngseok Lee

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110087 - 110087

Published: May 23, 2024

Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific responsible for perceiving elevated foods have remained unknown. By using

Language: Английский

Citations

7
The taste of vitamin C in Drosophila DOI
Bhanu Shrestha, Binod Aryal, Youngseok Lee

et al.

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(6)

Published: April 28, 2023

Language: Английский

Citations

16
Taste Detection of Flonicamid in Drosophila melanogaster DOI
Muhammad Atif, Youngseok Lee

Insect Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 104302 - 104302

Published: March 1, 2025

Language: Английский

Citations

0
Taste adaptations in blood-feeding arthropods: mechanisms and ecological implications DOI
Romina B. Barrozo,

Pablo Alejandro Bochicchio,

Isabel Ortega-Insaurralde

et al.

Current Opinion in Insect Science, Journal Year: 2025, Volume and Issue: unknown, P. 101342 - 101342

Published: Feb. 1, 2025

Language: Английский

Citations

0
Drosophila behavior genetics DOI
Ming Jiang, Masaharu Hoshi, Ayako Tonoki

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cholesterol taste avoidance in Drosophila melanogaster DOI Open Access
Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee

et al.

Published: April 7, 2025

The question as to whether animals taste cholesterol is not resolved. This study investigates the fruit fly, Drosophila melanogaster , capable of detecting through their gustatory system. We found that flies are indifferent low levels and avoid higher levels. avoidance mediated by receptor neurons (GRNs), demonstrating can cholesterol. responsive GRNs comprise a subset also respond bitter substances. Cholesterol detection depends on five ionotropic (IR) family members, disrupting any these genes impairs flies’ ability Ectopic expressions IRs in reveals two classes receptors, each with three shared one unique subunit. Additionally, expressing receptors sugar-responsive confers attraction cholesterol, GRNs.

Language: Английский

Citations

0