Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
15(2), P. 436 - 454
Published: Aug. 5, 2024
One
of
the
advancements
transdermal
drug
delivery
system
(TDDS)
is
development
microneedles
(MNs).
These
micron-sized
needles
are
used
for
delivering
various
types
drugs
to
address
disadvantage
other
techniques
as
well
oral
systems.
MNs
have
high
patient
acceptance
due
self-administration
with
minimally
invasive
and
pain
compared
parenteral
delivery.
Over
years,
methods
been
adopted
evolve
make
them
more
cost-effective,
accurate,
suitable
multiple
applications.
such
method
3D
printing
MNs.
The
MN
platforms
using
has
made
possible
by
improved
features
like
precision,
resolution,
feasibility
low-cost
raw
materials.
In
this
review,
we
tried
explain
MNs,
fabrication
methods,
materials
in
formulation
recent
applications
that
utilize
3D-printed
Biomaterials Research,
Journal Year:
2021,
Volume and Issue:
25(1)
Published: Feb. 12, 2021
Various
non-invasive
administrations
have
recently
emerged
as
an
alternative
to
conventional
needle
injections.
A
transdermal
drug
delivery
system
(TDDS)
represents
the
most
attractive
method
among
these
because
of
its
low
rejection
rate,
excellent
ease
administration,
and
superb
convenience
persistence
patients.
TDDS
could
be
applicable
in
not
only
pharmaceuticals
but
also
skin
care
industry,
including
cosmetics.
Because
this
mainly
involves
local
it
can
prevent
buildup
concentration
nonspecific
tissues
targeted
by
drug.
However,
physicochemical
properties
translate
multiple
obstacles
restrictions
delivery,
with
numerous
investigations
conducted
overcome
bottlenecks.
In
review,
we
describe
different
types
available
methods,
along
a
critical
discussion
specific
advantages
disadvantages,
characterization
potential
each
method.
Progress
research
on
methods
has
established
high
efficiency
inherent
TDDS,
which
is
expected
find
applications
wide
range
fields.
Nature Reviews Drug Discovery,
Journal Year:
2023,
Volume and Issue:
22(5), P. 387 - 409
Published: March 27, 2023
Poor
medication
adherence
is
a
pervasive
issue
with
considerable
health
and
socioeconomic
consequences.
Although
the
underlying
reasons
are
generally
understood,
traditional
intervention
strategies
rooted
in
patient-centric
education
empowerment
have
proved
to
be
prohibitively
complex
and/or
ineffective.
Formulating
pharmaceutical
drug
delivery
system
(DDS)
promising
alternative
that
can
directly
mitigate
many
common
impediments
adherence,
including
frequent
dosing,
adverse
effects
delayed
onset
of
action.
Existing
DDSs
already
positively
influenced
patient
acceptability
improved
rates
across
various
disease
types.
The
next
generation
systems
potential
instate
an
even
more
radical
paradigm
shift
by,
for
example,
permitting
oral
biomacromolecules,
allowing
autonomous
dose
regulation
enabling
several
doses
mimicked
single
administration.
Their
success,
however,
contingent
on
their
ability
address
problems
made
unsuccessful
past.
Improving
recognized
as
one
most
impactful
cost-effective
improving
general
population.
Here,
Baryakova
colleagues
assess
next-generation
discuss
impact
had
different
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1152 - 1152
Published: May 28, 2022
The
ideal
drug
delivery
system
has
a
bioavailability
comparable
to
parenteral
dosage
forms
but
is
as
convenient
and
easy
use
for
the
patient
oral
solid
forms.
In
recent
years,
there
been
increased
interest
in
transdermal
(TDD)
non-invasive
approach
that
generally
regarded
being
administer
more
vulnerable
age
groups,
such
paediatric
geriatric
patients,
while
avoiding
certain
concerns
arise
from
due
poor
absorbability
metabolism
concerns.
However,
despite
its
many
merits,
TDD
remains
restricted
select
few
drugs.
physiology
of
skin
poses
barrier
against
feasible
drugs,
limiting
applicability
only
those
drugs
possess
physicochemical
properties
allowing
them
be
successfully
delivered
transdermally.
Several
techniques
have
developed
enhance
permeability
Both
chemical
(e.g.,
thermal
mechanical)
passive
(vesicle,
nanoparticle,
nanoemulsion,
dispersion,
nanocrystal)
investigated
substances
across
skin.
Furthermore,
hybrid
approaches
combining
penetration
enhancement
technologies
with
physical
are
intensively
researched
improve
permeation
substances.
This
review
aims
summarize
trends
discuss
merits
drawbacks
various
chemical,
physical,
currently
improving
Microsystems & Nanoengineering,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: March 27, 2023
COVID-19
has
seriously
threatened
public
health,
and
transdermal
vaccination
is
an
effective
way
to
prevent
pathogen
infection.
Microneedles
(MNs)
can
damage
the
stratum
corneum
allow
passive
diffusion
of
vaccine
macromolecules,
but
delivery
efficiency
low,
while
iontophoresis
actively
promote
fails
transport
macromolecules
due
barrier
corneum.
Herein,
we
developed
a
wearable
iontophoresis-driven
MN
patch
its
device
for
active
efficient
macromolecule
delivery.
Polyacrylamide/chitosan
hydrogels
with
good
biocompatibility,
excellent
conductivity,
high
elasticity,
large
loading
capacity
were
prepared
as
key
component
storage
iontophoresis.
The
strategy
"press
poke,
delivery,
immune
response".
We
demonstrated
that
synergistic
effect
puncture
significantly
promoted
efficiency.
In
vitro
experiments
showed
amount
ovalbumin
delivered
transdermally
using
could
be
controlled
by
current.
vivo
immunization
studies
in
BALB/c
mice
inoculation
induced
response
was
even
stronger
than
traditional
intramuscular
injection.
Moreover,
there
little
concern
about
biosafety
patch.
This
system
low
cost,
user-friendly,
displays
showing
great
potential
self-administration
at
home.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4417 - 4441
Published: May 26, 2023
Rheumatoid
arthritis
is
a
chronic,
systemic
autoimmune
disease
predominantly
based
on
joint
lesions
with
an
extremely
high
disability
and
deformity
rate.
Several
drugs
have
been
used
for
the
treatment
of
rheumatoid
arthritis,
but
their
use
limited
by
suboptimal
bioavailability,
serious
adverse
effects,
nonnegligible
first-pass
effects.
In
contrast,
transdermal
drug
delivery
systems
(TDDSs)
can
avoid
these
drawbacks
improve
patient
compliance,
making
them
promising
option
(RA).
Of
course,
TDDSs
also
face
unique
challenges,
as
physiological
barrier
skin
makes
somewhat
limited.
To
overcome
this
maximize
efficiency,
evolved
in
terms
principle
facilitation
technology,
different
generations
derived,
which
significantly
improved
efficiency
even
achieved
individualized
controlled
delivery.
review,
we
summarize
systems,
corresponding
strategies,
applications
RA.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 13, 2024
Abstract
Transdermal
drug
delivery
is
of
vital
importance
for
medical
treatments.
However,
user
adherence
to
long-term
repetitive
poses
a
grand
challenge.
Furthermore,
the
dynamic
and
unpredictable
disease
progression
demands
pharmaceutical
treatment
that
can
be
actively
controlled
in
real-time
ensure
precision
personalization.
Here,
we
report
spatiotemporal
on-demand
patch
(SOP)
integrates
drug-loaded
microneedles
with
biocompatible
metallic
membranes
enable
electrically
triggered
active
control
release.
Precise
release
targeted
locations
(<1
mm
2
),
rapid
response
electrical
triggers
(<30
s),
multi-modal
operation
involving
both
stimulation
highlight
novelty.
Solution-based
fabrication
ensures
high
customizability
scalability
tailor
SOP
various
needs.
The
wireless-powered
digital-controlled
demonstrates
great
promise
achieving
full
automation
delivery,
improving
while
ensuring
precision.
Based
on
these
characteristics,
utilized
SOPs
sleep
studies.
We
revealed
programmed
exogenous
melatonin
from
improve
mice,
indicating
potential
values
basic
research
clinical
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(1), P. 88 - 88
Published: Jan. 9, 2025
One
class
of
cosmetic
compounds
that
have
raised
interest
many
experts
is
peptides.
The
search
for
ingredients
with
good
biocompatibility
and
bioactivity
has
led
to
the
use
peptides
in
products.
Peptides
are
novel
active
improve
collagen
synthesis,
enhance
skin
cell
proliferation,
or
decrease
inflammation.
Based
on
their
mechanism
action,
they
can
be
classified
into
signal
peptides,
carrier
neurotransmitter
inhibitor
enzyme
This
review
focuses
main
types
application
field,
underlining
limitations.
most
significant
drawbacks
poor
permeability
through
membranes,
which
limits
delivery
effectiveness.
As
a
result,
this
follows
methods
used
improving
stratum
corneum.
Increasing
peptide
bioavailability
stability
enhanced
desired
site
action
visible
effects
become
central
points
latest
research
due
promising
features.
For
purpose,
several
been
identified
described.
Physical
techniques
include
thermal
ablation
(radiofrequency
laser),
electrical
(electroporation,
iontophoresis),
mechanical
approach
(microneedles),
ultrasounds.
an
alternative,
innovative
formulations
developed
nano-systems
such
as
liposomes,
niosomes,
ethosomes,
nanoemulsions,
other
nanomaterials
reduce
irritation
product
purpose
provide
information
regarding
these
noteworthy
molecules
reasoning
behind
formulations.
