The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(16), P. 3833 - 3843
Published: April 11, 2024
The
construction
of
the
stratum
corneum
(SC)
is
crucial
to
problems
transdermal
drug
delivery.
SC
consists
keratinocyte
layers
and
lipid
matrix
surrounding
it.
Among
them,
barrier
for
many
exogenous
molecules,
mainly
composed
ceramides
(CERs),
free
fatty
acids
(FFA),
cholesterol
(CHOL).
In
this
work,
we
developed
single-component
(CERs,
CER-NS,
CER-EOS)
six
three-component
models,
each
model
was
simulated
by
using
GROMOS-54A7
force
field.
Short-period
phase
(SPP)
long-period
(LPP)
systems
were
established
separately,
area
per
(APL),
thickness,
order
carbon
chain
(S
ACS Pharmacology & Translational Science,
Journal Year:
2023,
Volume and Issue:
6(5), P. 783 - 801
Published: April 19, 2023
In
this
paper,
we
review
and
analyze
the
commonly
available
wound
healing
models
reported
in
literature
discuss
their
advantages
issues,
considering
relevance
translational
potential
to
humans.
Our
analysis
includes
different
vitro
silico
as
well
vivo
experimental
techniques.
We
further
explore
new
technologies
study
of
provide
an
all
encompassing
most
efficient
ways
proceed
with
experiments.
revealed
that
there
is
not
one
model
superior
can
give
translatable
results
human
research.
Rather,
are
many
have
specific
uses
for
studying
certain
processes
or
stages
healing.
suggests
when
performing
experiment
assess
therapies
enhance
healing,
must
consider
only
species
will
be
used
but
also
type
how
best
replicate
physiology
pathophysiology
Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Feb. 16, 2024
Burn
injuries
are
prevalent
and
life-threatening
forms
that
contribute
significantly
to
mortality
rates
due
associated
wound
infections.
The
management
of
burn
wounds
presents
substantial
challenges.
Hydrogel
exhibits
tremendous
potential
as
an
ideal
alternative
traditional
dressings
such
gauze.
This
is
primarily
attributed
its
three-dimensional
(3D)
crosslinked
polymer
network,
which
possesses
a
high
water
content,
fostering
moist
environment
supports
effective
healing.
Additionally,
hydrogel
facilitates
the
penetration
loaded
therapeutic
agents
throughout
surface,
combating
pathogens
through
hydration
effect
thereby
enhancing
healing
process.
However,
presence
eschar
formation
on
obstructs
passive
diffusion
therapeutics,
impairing
efficacy
dressing,
particularly
in
cases
severe
burns
involving
deeper
tissue
damage.
review
focuses
exploring
carrier
for
transdermal
drug
delivery
treatment.
Furthermore,
strategies
aimed
at
from
optimize
also
discussed.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
210, P. 115326 - 115326
Published: April 30, 2024
Transdermal
administration
remains
an
active
research
and
development
area
as
alternative
route
for
long-acting
drug
delivery.
It
avoids
major
drawbacks
of
conventional
oral
(gastrointestinal
side
effects,
low
bioavailability,
multiple
dosing)
or
parenteral
routes
(invasiveness,
pain,
psychological
stress
bio-hazardous
waste
generated
from
needles),
thereby
increasing
patient
appeal
compliance.
This
review
focuses
on
the
current
state
transdermal
delivery,
including
adhesive
patches,
microneedles,
molecularly
imprinted
polymeric
systems.
Each
subsection
describes
approach
key
considerations
in
formulation
development,
design,
process
parameters
with
schematics.
An
overview
commercially
available
(adhesive)
patches
delivery
(longer
than
24
h),
well
advanced
formulations
such
core-shell,
nanoformulations-incorporated
stimuli-responsive
3D-printed
polymers
is
also
provided.
Finally,
we
elaborated
translational
aspects,
challenges
patch
future
directions
clinical
advancement
new
products
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15980 - 15980
Published: Dec. 15, 2022
Nanomaterials
(NM)
arouse
interest
in
various
fields
of
science
and
industry
due
to
their
composition-tunable
properties
the
ease
modification.
They
appear
currently
as
components
many
consumer
products
such
sunscreen,
dressings,
sports
clothes,
surface-cleaning
agents,
computer
devices,
paints,
well
pharmaceutical
cosmetics
formulations.
The
use
NPs
for
topical
applications
improves
permeation/penetration
bioactive
compounds
into
deeper
layers
skin,
providing
a
depot
effect
with
sustained
drug
release
specific
cellular
subcellular
targeting.
Nanocarriers
provide
advances
dermatology
systemic
treatments.
Examples
are
non-invasive
method
vaccination,
advanced
diagnostic
techniques,
transdermal
delivery.
mechanism
action
NPs,
efficiency
skin
penetration,
potential
threat
human
health
still
open
not
fully
explained.
This
review
gives
brief
outline
latest
nanotechnology
achievements
used
prevent
treat
diseases.
We
highlighted
aspects
penetration
through
(influence
physical-chemical
experimental
models
methods
applied
improve
investigate
by
NPs).
summarizes
therapies
using
diagnose
diseases
(melanoma,
acne,
alopecia,
vitiligo,
psoriasis)
anti-aging
UV-protectant
nano-cosmetics.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1183 - 1183
Published: April 7, 2023
In
this
work,
we
aim
to
address
several
strategies
improve
transdermal
drug
delivery,
such
as
iontophoresis,
sonophoresis,
electroporation
and
micron.
We
also
propose
a
review
of
some
patches
their
applications
in
medicine.
TDDs
(transdermal
with
delayed
active
substances)
are
multilayered
pharmaceutical
preparations
that
may
contain
one
or
more
substances,
which,
systemic
absorption
is
achieved
through
intact
skin.
The
paper
presents
new
approaches
the
controlled
release
drugs:
niosomes,
microemulsions,
transfersomes,
ethosomes,
but
hybrid
nanoemulsions
microns.
novelty
lies
presentation
administration
drugs,
combined
medicine,
light
technological
developments.
Small,
Journal Year:
2023,
Volume and Issue:
19(29)
Published: April 7, 2023
Microneedles
have
recently
emerged
as
a
powerful
tool
for
minimally
invasive
drug
delivery
and
body
fluid
sampling.
To
date,
high-resolution
fabrication
of
microneedle
arrays
(MNAs)
is
mostly
achieved
by
the
utilization
sophisticated
facilities
expertise.
Particularly,
hollow
microneedles
usually
been
manufactured
in
cleanrooms
out
silicon,
resin,
or
metallic
materials.
Such
strategies
do
not
support
from
biocompatible/biodegradable
materials
limit
capability
multimodal
controlled
release
different
therapeutics
through
combination
injection
sustained
diffusion.
This
study
implements
low-cost
3D
printers
to
fabricate
relatively
large
needle
arrays,
followed
repeatable
shrink-molding
hydrogels
form
molds
solid
MNAs
with
controllable
sizes.
The
developed
strategy
further
enables
modulating
surface
topography
tailor
their
area
instantaneous
wettability
Hybrid
gelatin
methacryloyl
(GelMA)/polyethylene
glycol
diacrylate
(PEGDA)
are
fabricated
using
that
can
easily
penetrate
skin
enable
delivery.
proposed
method
holds
promise
affordable,
controllable,
scalable
researchers
clinicians
spatiotemporal
administration
sample
collection.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
15(4)
Published: April 11, 2023
Abstract
Transdermal
delivery
of
drugs
offers
an
interesting
alternative
for
the
administration
molecules
that
present
certain
troubles
when
delivered
by
oral
route.
It
can
produce
systemic
effects
or
perform
a
local
action
formulation
exerts
optimal
controlled
drug
release
targeted
to
specific
cell
type
site.
also
avoids
several
inconveniences
such
as
hepatic
first
pass
effect,
gastric
pH‐induced
hydrolysis,
malabsorption
because
diseases
surgeries,
and
unpleasant
organoleptic
properties.
Nanomedicine
microneedle
array
patches
(MAPs)
are
two
trendiest
systems
applied
transdermal
research
nowadays.
However,
skin
is
protective
barrier
nanoparticles
(NPs)
cannot
through
intact
stratum
corneum
.
The
association
NPs
MAPs
(NPs@MAPs)
work
synergistically,
since
assist
bypass
outer
layers,
contribute
system
providing
delivery.
Vaccination
tailored
therapies
have
been
proposed
fields
where
both
great
potential
due
inherent
characteristics.
conception
easy
use
could
allow
self‐administration
therefore
facilitate
mass
vaccination
campaigns
in
undeveloped
areas
with
weak
healthcare
services.
Additionally,
nanomedicine
being
explored
platform
personalize
important
field
oncology.
In
this
we
show
recent
insights
prove
benefits
NPs@MAPs
analyze
prospects
discrete
interest
industry
NPs@MAPs,
evaluating
different
limiting
steps
restricts
translation
clinical
practice.
This
article
categorized
under:
Nanotechnology
Approaches
Biology
>
NA
Therapeutic
Drug
Discovery
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
200, P. 115028 - 115028
Published: July 28, 2023
Lipid-based
nanocarriers
have
been
extensively
investigated
for
their
application
in
drug
delivery.
Particularly,
liposomes
are
now
clinically
established
treating
various
diseases
such
as
fungal
infections.
In
contrast,
extracellular
vesicles
(EVs)
-
small
cell-derived
nanoparticles
involved
cellular
communication
just
recently
sparked
interest
carriers
but
development
is
still
at
the
preclinical
level.
To
drive
this
further,
methods
and
technologies
exploited
context
of
liposome
research
should
be
applied
domain
EVs
to
facilitate
accelerate
clinical
translation.
One
crucial
steps
EV-based
therapeutics
designing
them
proper
dosage
forms
specific
applications.
This
review
offers
a
comprehensive
overview
state-of-the-art
polysaccharide-based
hydrogel
platforms
designed
artificial
natural
with
delivery
skin.
We
discuss
physicochemical
biological
properties
try
create
sound
basis
optimization
EV-embedded
hydrogels
versatile
therapeutic
avenues.
