Long COVID: An inevitable sequela of SARS-CoV-2 infection

Journal of Microbiology Immunology and Infection, Journal Year: 2022, Volume and Issue: 56(1), P. 1 - 9

Published: Oct. 15, 2022

At present, there are more than 560 million confirmed cases of the coronavirus disease 2019 (COVID-19) worldwide. Although 98% patients with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection can survive COVID, a significant portion survivors develop residual health problems, which is termed as long COVID. COVID-19 generally associated high risk asymptomatic or mild also show The definition COVID inconsistent and its clinical manifestations protean. In addition to general symptoms, such fatigue, affect many organ systems, including respiratory, neurological, psychosocial, cardiovascular, gastrointestinal, metabolic systems. Moreover, may experience exercise intolerance impaired daily function quality life. Long be caused by SARS-CoV-2 direct injury immune/inflammatory response. Assessment requires comprehensive evaluation, history taking, physical examination, laboratory tests, radiography, functional tests. However, no known effective treatment for Based on limited evidence, vaccines help prevent development As new entity that constantly evolving, still unknowns, further investigation warranted enhance our understanding this disease.

Language: Английский

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Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition

Biomedicines, Journal Year: 2022, Volume and Issue: 10(10), P. 2562 - 2562

Published: Oct. 13, 2022

Pain after an acute Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) condition (post-COVID pain) is becoming a new healthcare emergency. Precision medicine refers to evidence-based method of grouping patients based on their diagnostic/symptom presentation then tailoring specific treatments accordingly. Evidence suggests that post-COVID pain can be categorized as nociceptive (i.e., attributable the activation peripheral receptive terminals primary afferent neurons in response noxious chemical, mechanical, or thermal stimuli), neuropathic associated with lesion somatosensory nervous system limited “neuroanatomically plausible” distribution system), nociplastic arising from altered nociception despite no clear evidence actual threatened tissue damage causing nociceptors for pain), mixed type (when two phenotypes co-exist). Each these may require different treatment approach maximize effectiveness. Accordingly, ability classify into one would likely critical producing successful outcomes. The 2021 International Association Study (IASP) clinical criteria grading provide framework classifying within precision approach. Here we present data supporting possibility phenotypes, using IASP classification criteria, focus pain, which probably mechanism involved pain. Nociplastic usually comorbid symptomology (e.g., poor sleep quality, fatigue, cognitive–emotional disturbances, etc.) considered more difficult treat than other types, nuanced multimodal achieve better

Language: Английский

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Consistency of inconsistency in long‐COVID‐19 pain symptoms persistency: A systematic review and meta‐analysis

Pain Practice, Journal Year: 2023, Volume and Issue: 24(1), P. 120 - 159

Published: July 21, 2023

Abstract Introduction Individuals recovering from acute COVID‐19 episodes may continue to suffer various ongoing symptoms, collectively referred as Long‐COVID. Long‐term pain symptoms are amongst the most common and clinically significant be reported for this post‐COVID‐19 syndrome. Objectives This systematic review meta‐analysis aimed evaluate proportions of persisting experienced by individuals past phase identify their associated functional consequences inflammatory correlates. Methods Two online databases were systematically searched inception until 31 March 2022. We primary research articles in English, which evaluated after laboratory‐confirmed resolution specifically on and/or outcomes. Results Of 611 identified articles, 26 included, used data extraction, assessed methodological quality risk bias two independent reviewers. Pain grouped under one six major domains, serving our co‐outcomes. Proportional meta‐analyses pooled logit‐transformed values single performed using random‐effects‐restricted maximum‐likelihood model. An estimated 8%, 6%, 18%, 17%, 12% continued report persistence chest, gastrointestinal, musculoskeletal joint, muscle, general body, nervous system‐related respectively, up year COVID‐19. Considerable levels heterogeneity demonstrated across all results. Functional quality‐of‐life impairments some biomarker elevations with long‐COVID symptoms. Conclusion study's findings suggest that although not well characterized, being non‐negligible those episodes, thus highlighting importance future efforts focus aspect.

Language: Английский

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Role of Endothelium in Cardiovascular Sequelae of Long COVID

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2239 - 2239

Published: Aug. 9, 2023

The global action against coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, shed light on endothelial dysfunction. Although primarily affects the pulmonary system, multiple studies have documented pan-vascular involvement in COVID-19. virus is able to penetrate barrier, damaging it directly or indirectly and causing endotheliitis multi-organ injury. Several mechanisms cooperate development of dysfunction, including cell injury pyroptosis, hyperinflammation cytokine storm syndrome, oxidative stress reduced nitric oxide bioavailability, glycocalyx disruption, hypercoagulability, thrombosis. After acute-phase some patients reported signs symptoms a systemic disorder known as long COVID, which broad range cardiovascular (CV) disorders emerged. To date, exact pathophysiology COVID remains unclear: addition persistence infection mechanisms, specific pathways CV damage been postulated, such persistent viral reservoirs heart an autoimmune response cardiac antigens through molecular mimicry. aim this review provide overview main patterns enduring activation following offer latest summary complications COVID.

Language: Английский

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Global prevalence of post-COVID-19 sleep disturbances in adults at different follow-up time points: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2023, Volume and Issue: 71, P. 101833 - 101833

Published: Aug. 11, 2023

Language: Английский

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Post-COVID-19 Syndrome Comprehensive Assessment: From Clinical Diagnosis to Imaging and Biochemical-Guided Diagnosis and Management

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 533 - 533

Published: Feb. 14, 2023

The COVID-19 outbreak was first reported in 2019, causing massive morbidity and mortality. majority of the patients survived developed Post-COVID-19 Syndrome (PC19S) varying severity. Currently, diagnosis PC19S is achieved through history symptomatology that cannot be explained by an alternative diagnosis. However, heavy reliance on subjective reporting prone to errors. Besides, there no unified diagnostic assessment tool classify clinical severity patients. This leads significant difficulties when managing terms public resource utilization, progression monitorization rehabilitation plan formulation. narrative review aims current evidence based triple assessment: symptomatology, biochemical analysis imaging evidence. Further tools can monitor patient’s progression, prognosis intervals monitoring. It also highlights high-risk features for closer earlier Rehabilitation programs related trials are evaluated; however, most them focus cardiorespiratory fitness psychiatric presentations such as anxiety depression. research required establish objective comprehensive facilitate management plans.

Language: Английский

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Vortioxetine improves physical and cognitive symptoms in patients with post-COVID-19 major depressive episodes

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 70, P. 21 - 28

Published: Feb. 8, 2023

Language: Английский

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Treatable traits for long COVID

Respirology, Journal Year: 2023, Volume and Issue: 28(11), P. 1005 - 1022

Published: Sept. 16, 2023

Long COVID, or post-acute COVID-19 sequelae, is experienced by an estimated one in eight adults following acute COVID-19. COVID a new and complex chronic health condition that typically includes multiple symptoms cross organ systems fluctuate over time; one-size-fits-all approach is, therefore, not likely to be appropriate nor relevant for long treatment. 'Treatable Traits' personalized medicine approach, purpose-built address the complexity heterogeneity of conditions. This comprehensive review aimed understand how treatable traits could applied first identifying most prevalent then available evidence strategies target these traits. An umbrella 22 systematic reviews identified 34 complications common with grouped into trait clusters: neurological, chest, psychological, pain, fatigue, sleep impairment, functional impairment other. A randomized control trials 18 studies explored different intervention approaches prevention (k = 4) management 14). While single study reported metformin as effective prevention, findings need replicated consensus required around define clinical trial endpoint. For management, current supports exercise training respiratory muscle chest limitation clusters. there are exploring interventions targeting other traits, further high-quality RCTs needed, particularly clusters pain impairment.

Language: Английский

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Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Abstract Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies PCS. still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding

Language: Английский

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Trajectory of post-COVID brain fog, memory loss, and concentration loss in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 9, 2023

This study aimed to apply Sankey plots and exponential bar for visualizing the trajectory of post-COVID brain fog, memory loss, concentration loss in a cohort previously hospitalized COVID-19 survivors.A sample 1,266 patients due during first wave pandemic were assessed at 8.4 (T1), 13.2 (T2), 18.3 (T3) months after hospital discharge. They asked about presence following self-reported cognitive symptoms: fog (defined as self-perception sluggish or fuzzy thinking), unusual forgetfulness), not being able maintain attention). We symptoms that individuals had experienced previously, they attributed them acute infection. Clinical hospitalization data collected from medical records.The revealed prevalence was 8.37% (n = 106) T1, 4.7% 60) T2, 5.1% 65) T3, whereas 14.9% 189) 11.4% 145) 12.12% 154) T3. Finally, decreased 6.86% 87) 4.78% 2.63% 33) The recovery curves show decreasing trend, indicating these recovered years regression models did reveal any record associated with long term.The use shows fluctuating evolution In addition, decrease No risk factors identified this cohort.

Language: Английский

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