PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm DOI Creative Commons

Aref Shariati,

Zahra Chegini, Ehsanollah Ghaznavi‐Rad

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: June 21, 2022

The biofilm community of microorganisms has been identified as the dominant mode microbial growth in nature and a common characteristic different such Pseudomonas aeruginosa, Staphylococcus aureus, epidermidis. structure helps protection from environmental threats including host immune system antimicrobial agents. Thus, led to higher prevalence multidrug-resistant (MDR) strains recent years. In this regard, use new class antibiotics, natural compounds, anti-biofilm enzymes considered for destruction biofilm. However, drawbacks low penetration, high susceptibility degradation, instability, poor solubility aqueous solutions limit agents (ABAs) clinical setting. As such, studies have using poly lactic- co -glycolic acid (PLGA)-based nanoplatforms (PLGA NPFs) delivery ABAs that reported promising results. These particles, due proper drug loading release kinetics, could suppress attachment, colonization, formation long time. Additionally, PLGA NPFs, because drug-loading efficiencies, hydrophilic surface, negative charge, electrostatic interaction, lead effective penetration antibiotics deeper layer biofilm, thereby eliminating NPFs be potential candidate coating catheters other medical material surfaces inhibition exact interaction should evaluated animal studies. future goal will develop formulations systems can used treatment MDR since interactions these structures are not elucidated. present review article, we discussed various aspects usage along with methods procedures improving NPF efficacy against

Language: Английский

Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs DOI

Riya Mahar,

Arpita Chakraborty,

Nidhi Nainwal

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(1)

Published: Jan. 18, 2023

Language: Английский

Citations

44
Self-Assembling Peptides: From Design to Biomedical Applications DOI Open Access
Sara La Manna, Concetta Di Natale, Valentina Onesto

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12662 - 12662

Published: Nov. 23, 2021

Self-assembling peptides could be considered a novel class of agents able to harvest an array micro/nanostructures that are highly attractive in the biomedical field. By modifying their amino acid composition, it is possible mime several biological functions; when assembled micro/nanostructures, they can used for variety purposes such as tissue regeneration and engineering or drug delivery improve release and/or stability reduce side effects. Other significant advantages self-assembled involve biocompatibility ability efficiently target molecular recognition sites. Due intrinsic characteristics, peptide capable load both hydrophobic hydrophilic drugs, suitable achieve triggered at disease sites by inserting structure’s stimuli-responsive moieties. The focus this review was summarize most recent studies on with emphasis application

Language: Английский

Citations

67
Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications DOI Open Access

Monika Gosecka,

Mateusz Gosecki,

Daria Jaworska‐Krych

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: April 3, 2023

Abstract Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are wide interest in tissue engineering. due biocompatibility porous structure, valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on development hydrogel with ability increase solubility hydrophobic However, pronounced discrepancy between character hydrogels nature numerous pharmacologically active compounds is problematic. In recent years, different strategies applied using special polymer constructs or composite materials exploiting advanced scientific knowledge area lipid‐based nano‐ microcarriers hydrophobization turns out be not only terms achieving dissolve poorly soluble drugs but also proves crucial obtaining bioadhesion wet conditions, also, unexpected abnormal water swelling behavior, well mechanical properties such dissipation mechanism self‐healable properties. This review mainly focused advances usage hydrophobized biomedical applications.

Language: Английский

Citations

36
Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery DOI
Atefeh Malek-Khatabi,

Malihe Sadat Razavi,

Alyeh Abdollahi

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(16), P. 5390 - 5409

Published: Jan. 1, 2023

Microneedles (MNs) have recently been found to applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue attract increasing attention due their capability bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve targeted intradermal delivery of drugs vaccines improve transdermal level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility biodegradability. Currently, PLGA-based MNs noticeable tendency be utilized as system. This study focuses on most recent advances MNs. Both PLGA nanoparticle-based matrix-based MNs, created for vaccines, drugs, proteins other therapeutic agents, are discussed. The paper also discusses various types potential applications. Finally, prospects challenges reviewed.

Language: Английский

Citations

34
PLGA Particles in Immunotherapy DOI Creative Commons
Dennis J. Horvath, Michael Basler

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 615 - 615

Published: Feb. 11, 2023

Poly(lactic-co-glycolic acid) (PLGA) particles are a widely used and extensively studied drug delivery system. The favorable properties of PLGA such as good bioavailability, controlled release, an excellent safety profile due to the biodegradable polymer backbone qualified for approval by authorities application platform in humas. In recent years, immunotherapy has been established potent treatment option variety diseases. However, immunomodulating drugs rely on targeted specific immune cell subsets often rapidly eliminated from Loading with can protect therapeutic compounds premature degradation, direct tissues or cells, ensure sustained release. These present ideal immunotherapy. Here, we review advances particulate systems fields allergy, autoimmunity, infectious diseases, cancer.

Language: Английский

Citations

29
PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach DOI Open Access
Rezvan Jamaledin, Rossella Sartorius, Concetta Di Natale

et al.

Journal of nanostructure in chemistry, Journal Year: 2023, Volume and Issue: 14(5), P. 307 - 322

Published: Jan. 11, 2023

Language: Английский

Citations

24
Microstructure Formation and Characterization of Long-Acting Injectable Microspheres: The Gateway to Fully Controlled Drug Release Pattern DOI Creative Commons
Mengdi Wang, Shan Wang, Changhao Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1571 - 1595

Published: Feb. 1, 2024

Abstract: Long-acting injectable microspheres have been on the market for more than three decades, but if calculated brand name, only 12 products approved by FDA due to numerous challenges in achieving a fully controllable drug release pattern. Recently, and researches critical factors that determine kinetics of shifted from evaluating typical physicochemical properties exploring microstructure. The microstructure mainly includes spatial distribution dispersed state drug, PLGA pores, which has considered as one most important characteristics microspheres, especially when comparative characterization (Q3) recommended bioequivalence assessment. This review extracted main variables affecting formation microsphere formulation compositions preparation processes highlighted latest advances techniques. further understanding significant reference value development long-acting particularly generic microspheres. Keywords: microsphere, microstructure, PLGA, controlled

Language: Английский

Citations

11
Cannabidiol-loaded microparticles embedded in a porous hydrogel matrix for biomedical applications DOI Creative Commons
Carla David, Jaqueline F. de Souza, Adriana Fernandes da Silva

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2024, Volume and Issue: 35(1)

Published: Feb. 14, 2024

Abstract In this study, poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with cannabidiol (CBD) were synthesized (PLGA@CBD microparticles) and embedded up to 10 wt% in a chondroitin sulfate/polyvinyl alcohol hydrogel matrix. vitro chemical, physical, biological assays carried out validate the potential use of modified hydrogels as biomaterials. The had spherical morphology narrow range size distribution. CBD encapsulation efficiency was around 52%, loading approximately 50%. Microparticle addition caused minor changes their morphology, FTIR thermal analyses confirmed these changes. Swelling degree total porosity reduced presence microparticles, but similar hydrophilic degradation phosphate buffer solution behaviors observed by all hydrogels. Rupture force maximum strain at rupture higher hydrogels, whereas modulus elasticity across materials. Viability primary human dental pulp cells 21 days generally not influenced PLGA@CBD microparticles. control showed no antimicrobial activity against Staphylococcus aureus , 5% 10% inhibition zones. conclusion, fabricated successfully Despite hydrophobic nature CBD, physicochemical morphological properties for without CBD-loaded data reported study suggested that original biomaterial oil has characteristics could enable it be used scaffold tissue/cellular regeneration. Graphical

Language: Английский

Citations

8
Drug-Loaded Microspheres on NIR-Responsive PLA/MXene Scaffolds: Controlled Release and Bone Tissue Regeneration DOI

Yiqiao Zhao,

Hao Chen,

Jiahao Fu

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The resection of bone tumors results in large defects with some residual tumor cells, and the treatment this type defect area often faces a dilemma, namely, trade-off between repair antitumor after tumors. In order to promote local repair, at same time inhibit recurrence by continuous controlled drug administration, we developed multifunctional NIR-responsive scaffold, whose main components are polylactic acid MXene, loaded PLGA/DOX microspheres, hope that scaffold can take into account both bidirectional modulation effect NIR. showed 1% MXene content had relatively good performance photothermal therapy (PT) other aspects, it could be smoothly increased 50 °C within 2 min under NIR illumination, release microspheres was 10% illumination compared body temperature. vivo experiments animals effectively limited situ cells lung metastasis able osteogenic differentiation irradiation. Therefore, not only control drugs but also enhance through PT formation, which provides application solution for integrated surgery.

Language: Английский

Citations

1
Development of itaconate polymer microparticles for intracellular regulation of pro-inflammatory macrophage activation DOI Open Access

Kaitlyn E. Woodworth,

Zachary S.C.S. Froom,

Nicola Osborne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. Its use in immunomodulatory therapies has faced limitations due to inherent challenges achieving controlled delivery requirements for high extracellular concentrations achieve internalization highly polar small molecule its intracellular therapeutic activity. Microparticle (MP)-based strategies are promising approach metabolites through macrophage phagocytosis subsequent polymer degradation-based delivery. Toward goal IA, degradable polyester polymer-(poly(itaconate-co-dodecanediol)) based IA microparticles (IA-MPs) were generated using emulsion method, forming micron-scale (∼ 1.5 µm) microspheres. IA-MPs characterized with respect their material properties release kinetics inform particle fabrication. Treatment murine bone marrow-derived macrophages optimized concentration 0.1 mg/million cells enabled phagocytosis-mediated low levels cytotoxicity. Flow cytometry demonstrated IA-MP-specific regulation IA-sensitive inflammatory targets. Metabolic analyses that IA-MP inhibited oxidative metabolism induced glycolytic reliance, consistent established mechanism IA-associated inhibition succinate dehydrogenase. This development IA-based provides basis additional innovative metabolite-based microparticle drug systems treatment disease.

Language: Английский

Citations

1