Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114704 - 114704
Published: April 1, 2025
Language: Английский
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522
Published: Dec. 21, 2022
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.
Language: Английский
Citations
259
Antibiotics, Journal Year: 2022, Volume and Issue: 11(10), P. 1451 - 1451
Published: Oct. 21, 2022
Antimicrobial resistance has become a critical global health problem due to the abuse of conventional antibiotics and rise multi-drug-resistant microbes. peptides (AMPs) are group natural that show promise as next-generation their low toxicity host, broad spectrum biological activity, including antibacterial, antifungal, antiviral, anti-parasitic activities, great therapeutic potential, such anticancer, anti-inflammatory, etc. Most importantly, AMPs kill bacteria by damaging cell membranes using multiple mechanisms action rather than targeting single molecule or pathway, making it difficult for bacterial drug develop. However, experimental approaches used discover design new very expensive time-consuming. In recent years, there been considerable interest in silico methods, traditional machine learning (ML) deep (DL) approaches, discovery. While few papers summarizing computational AMP prediction none them focused on DL methods. this review, we aim survey latest methods achieved approaches. First, biology background is introduced, then various feature encoding represent features peptide sequences presented. We explain most popular techniques highlight works based classify novel sequences. Finally, discuss limitations challenges prediction.
Language: Английский
Citations
71
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(9), P. 3659 - 3677
Published: Feb. 28, 2023
Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a covalently coupled to multifunctional peptide via cleavable linker. As an emerging prodrug strategy, PDCs not only preserve the function and bioactivity peptides but also release drugs responsively with property linkers. Given ability significantly improve circulation stability targeting in vivo reduce toxic side effects drugs, have already been extensively applied delivery. Herein, we review types mechanisms peptides, linkers used construct PDCs, summarize clinical applications challenges PDC drugs.
Language: Английский
Citations
54
Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(1), P. 31 - 42
Published: Jan. 1, 2025
Language: Английский
Citations
3
The Journal of Physical Chemistry B, Journal Year: 2023, Volume and Issue: 127(9), P. 1857 - 1871
Published: Feb. 22, 2023
The design of novel cancer drug nanocarriers is critical in the framework therapeutics. Nanomaterials are gaining increased interest as delivery systems. Self-assembling peptides constitute an emerging class highly attractive nanomaterials with promising applications delivery, they can be used to facilitate release and/or stability while reducing side effects. Here, we provide a perspective on peptide self-assembled for and highlight aspects metal coordination, structure stabilization, cyclization, well minimalism. We review particular challenges nanomedicine criteria and, finally, future perspectives addressing portion via self-assembling consider that intrinsic advantages such systems, along increasing progress computational experimental approaches their study design, could possibly lead classes single or multicomponent systems incorporating materials delivery.
Language: Английский
Citations
38
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)
Published: March 21, 2023
Short designer self-assembling peptide (dSAP) biomaterials are a new addition to the hemostat group. It may provide diverse and robust toolbox for surgeons integrate wound microenvironment with much safer stronger hemostatic capacity than conventional materials agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, internal medical bleeding (IMB), respect optimal formulation, dSAP ingenious nanofiber alternatives make bioactive neural scaffold, nasal packing, large coverage gastrointestinal surgery (esophagus, gastric lesion, duodenum, lower digestive tract), epicardiac cell-delivery carrier, transparent matrix barrier, so on. Herein, multiple surgical specialties, dSAP-biomaterial-based nano-hemostats achieve safe, effective, immediate hemostasis, facile healing, potentially reduce risks delayed rebleeding, post-operative or related complications. The biosafety vivo, indications, tissue-sealing quality, feasibility, local usability addressed comprehensively sequentially pursued develop useful techniques better performance. Here, state of art all-round advancements nano-hemostatic approaches provided. Relevant critical insights will inspire exciting investigations on nanotechnology, next-generation biomaterials, promising prospects clinics.
Language: Английский
Citations
31
Gels, Journal Year: 2022, Volume and Issue: 8(9), P. 569 - 569
Published: Sept. 7, 2022
Thixotropy is a fascinating feature present in many gel systems that has garnered lot of attention the medical field recent decades. When shear stress applied, transforms into sol and immediately returns to its original state when resting. The thixotropic nature hydrogel inspired scientists entrap release enzymes, therapeutics, other substances inside human body, where acts as drug reservoir can sustainably therapeutics. Furthermore, hydrogels have been widely used various therapeutic applications, including delivery, cornea regeneration osteogenesis, name few. Because their inherent biocompatibility structural diversity, peptides are at forefront cutting-edge research this context. This review will discuss rational design self-assembly peptide-based with some representative examples, followed by biomedical applications.
Language: Английский
Citations
35
Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10
Published: June 21, 2022
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability tends to occur among the young, seriously affecting patients’ lives quality of life. The key aims repairing include preventing secondary nerve injury, inhibiting glial scarring inflammatory response, promoting regeneration. Hydrogels have good biocompatibility degradability, low immunogenicity, easy-to-adjust mechanical properties. While providing structural scaffolds tissues, hydrogels can also be used as slow-release carriers in neural tissue engineering promote cell proliferation, migration, differentiation, well accelerate repair damaged tissue. This review discusses characteristics their advantages delivery vehicles, expounds on progress made hydrogel therapy (alone or combined with cells molecules) SCI. In addition, we discuss prospects clinical research provide new ideas treatment
Language: Английский
Citations
31
Biofabrication, Journal Year: 2023, Volume and Issue: 16(1), P. 012001 - 012001
Published: Sept. 27, 2023
Abstract Bioprinting is an additive manufacturing technique that combines living cells, biomaterials, and biological molecules to develop biologically functional constructs. Three-dimensional (3D) bioprinting commonly used as in vitro modeling system a more accurate representation of vivo conditions comparison two-dimensional cell culture. Although 3D has been utilized various tissue engineering clinical applications, it only takes into consideration the initial state printed scaffold or object. Four-dimensional (4D) emerged recent years incorporate additional dimension time within scaffolds. During 4D process, external stimulus exposed construct, which ultimately changes its shape functionality. By studying how structures embedded cells respond stimuli, researchers can gain deeper understanding functionality native tissues. This review paper will focus on biomaterial breakthroughs newly advancing field their applications regeneration. In addition, use smart biomaterials printing mechanisms for discussed demonstrate potential insights novel applications. To address current challenges with this technology, we conclude future perspectives involving incorporation scaffolds self-assembling nanomaterials bioprinted
Language: Английский
Citations
22
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2147 - 2147
Published: June 22, 2022
Proteins are functional building blocks of living organisms that exert a wide variety functions, but their synthesis and industrial production can be cumbersome expensive. By contrast, short peptides very convenient to prepare at low cost on large scale, self-assembly into nanostructures gels is popular avenue for protein biomimicry. In this Review, we will analyze the last 5-year progress incorporation bioactive motifs self-assembling mimic proteins extracellular matrix (ECM) guide cell fate inside hydrogel scaffolds.
Language: Английский
Citations
26