Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma DOI Open Access
Gabriela Mitea, Verginica Schröder, Irina Mihaela Iancu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3612 - 3612

Published: Oct. 26, 2024

Background: With a significant increase in both incidence and mortality, oral cancer—particularly squamous cell carcinoma (OSCC)—is one of the main causes death developing countries. Even though there is evidence advances surgery, chemotherapy, radiotherapy, overall survival rate for patients with OSCC has improved, but by small percentage. This may be due, on hand, to fact that disease diagnosed when it at too-advanced stage, metastases are already present. Methods: review explores therapeutic potential natural herbal products their use as adjuvant therapies treatment cancer from online sources databases (PubMed, Web Science, Google Scholar, Research Gate, Scopus, Elsevier). Results: if classic known effective, they often produce many serious side effects can create resistance. Certain plant compounds offer complementary approach inducing apoptosis, suppressing tumor growth, improving chemotherapy effectiveness. The integration these conventional treatments obtain remarkable synergistic represents major point interest authors. highlights study molecular mechanisms efficiency vitro vivo models, well strategic ways which drugs administered optimize real contexts. Conclusions: have impact oncology community, creating new inspirations development more safer less toxic potential.

Language: Английский

Molecular evidence for the efficacy of PBM therapy in the treatment of Oral lichen planus DOI Creative Commons
Maria Zaharieva Mutafchieva, Milena Draganova-Filipova, Plamen Zagorchev

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104479 - 104479

Published: Jan. 1, 2025

Oral lichen planus (OLP) is a chronic inflammatory disease, in which T-Lymphocytes induce apoptosis of basal keratinocytes, leading to the formation symptomatic lesions. It assumed that blocking cell death program and enhancing proliferation would be crucial healing process. The aim study was verify efficacy Photobiomodulation (PBM) OLP management, by evaluating effects laser irradiation on processes proliferation. Twenty patients with underwent PBM 810nm diode (0.5W, 30s, 1.2J/cm significantly reduced patients' pain intesity improved clinical signs tissue sections demonstrated lower staining for bcl-2 Ki-67 compared healthy controls. After therapy expression increased significantly. An enhance immunoreactivity revealed predominantly atrophic-erosive epithelium. an effective treatment modality patients. Erosive forms disease responded better than keratotic subtypes. At molecular level, likely recover impaired cycle mechanisms keratinocyte

Language: Английский

Citations

2
Lichen Planus: What is New in Diagnosis and Treatment? DOI
Burak Tekin, Fangyi Xie, Julia S. Lehman

et al.

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: 25(5), P. 735 - 764

Published: July 9, 2024

Language: Английский

Citations

11
Novel Functional Dressing Materials for Intraoral Wound Care DOI
Yutang Ding,

Zhou Zhu,

Xin Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, distinctive healing processes within oral cavity. They have common occurrence yet frequently inflict significant inconvenience pain on patients, causing serious decline in quality life. A variety novel functional dressings specifically designed for moist dynamic environment been developed realized accelerated improved wound healing. Thoroughly analyzing summarizing these materials is paramount importance enhancing understanding proficiently managing intraoral wounds. In this review, particular characteristics are firstly described. Up-to-date knowledge various forms, properties, applications existing products then intensively discussed, which categorized into animal products, plant extracts, natural polymers, synthetic products. To conclude, review presents comprehensive framework currently available dressings, with an aim to provoke inspiration future studies design more convenient versatile materials.

Language: Английский

Citations

8
Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus DOI Creative Commons
Cristina Popa,

Ana Maria Sciucă,

Bianca-Andreea Onofrei

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 692 - 692

Published: March 26, 2024

Erosive oral lichen planus (EOLP) represents a significant challenge in dental and medical management due to its chronic inflammatory nature, painful symptoms, impact on quality of life. This study aims evaluate the current diagnostic approach with novel non-invasive techniques, such as dermoscopy, also landscape treatment options for EOLP, focusing efficacy, safety, challenges that it present clinical practice. Through comprehensive literature review, we explored use topical corticosteroids, systemic immunosuppressants, biologics, Janus kinase (JAK) inhibitors treating alongside examining patient compliance, psychological impacts, risk adverse effects recurrence. Our findings reveal while corticosteroids are cornerstone EOLP treatment, offering symptomatic relief, their long-term is limited by side tolerance development. Systemic therapies biologics provide alternatives refractory cases but necessitate careful effect monitoring. JAK show promise an innovative avenue require more evidence safety efficacy. highlights necessity personalized approaches variable disease course response underscoring importance multidisciplinary strategy managing EOLP. The complexity compounded life demands ongoing research into targeted therapies, establishment standardized protocols, development effective outcome measures improve care outcomes.

Language: Английский

Citations

6
Inflammatory cytokines and oral lichen planus: a Mendelian randomization study DOI Creative Commons
Xin Chen, Simin Zhang, Xiao Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Background Inflammatory cytokines have long been considered closely related to the development of oral lichen planus (OLP), and we further explored causal relationship between two by Mendelian randomization (MR) method. Methods We performed bidirectional MR analyses large genome-wide association studies (GWAS). The data included a large-scale OLP dataset, as well datasets 41 inflammatory cytokines. All were obtained from University Bristol database, which includes cytokines, GWAS Catalog 91 Finngen 6411 cases 405770 healthy controls. used inverse variance weighted (IVW) method, MR-Egger median simple mode method analyze OLP, also combined with sensitivity analysis verify robustness results. meta-analysis positive or potentially results for same genes confirm reliability final Results primarily IVW corrected using Benjamin Hochberg (BH) When p<0.00038 (0.05/132), are significantly causal; when 0.00038<p<0.05, causal. found total 7 significant potential associations (University database: 2, 5). In reverse analysis, that 30 associated 5, 25). After meta-analysis, finally determined there was 3 in forward most FGF21 (p=0.02954, odds ratio (OR): 1.113, 95% confidence interval (95%CI): 1.011-1.226). 14 causally PLAU (p=0.00002, OR: 0.951, 95%CI: 0.930-0.973). Conclusion There is some may play an important role pathogenesis require attention.

Language: Английский

Citations

5
Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches DOI Open Access
Houriah Yasir Nukaly, Ibrahim R. Halawani,

Saja Mohammed S. Alghamdi

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(17), P. 5280 - 5280

Published: Sept. 5, 2024

: Oral Lichen Planus (OLP) is a common immune-mediated inflammatory disorder affecting the oral mucosa, impacting 0.5% to 2% of global population, primarily middle-aged women. Immunological dysregulation key factor in OLP's pathogenesis, involving CD4+ T helper and CD8+ cytotoxic cells. The World Health Organization (WHO) classifies OLP as potentially malignant disorder, with risk squamous cell carcinoma (OSCC) developing up lesions. This narrative review aims provide comprehensive overview etiopathogenesis, clinical manifestations, diagnostic criteria, therapeutic strategies for OLP, informing practice guiding future research.

Language: Английский

Citations

5
Combined effect of topical sulfasalazine for oral lichen planus management: a randomized clinical trial DOI Creative Commons
Mai Zakaria, Basma Mostafa, Ibrahim El Refai

et al.

Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Aim: The present study was designed to assess the effectiveness of topical application sulfasalazine in combination with topically applied corticosteroids versus using steroids alone as standard control management symptomatic oral lichen planus (OLP). Methods: trial involved 46 participants having OLP. Subjects included were divided into two equal groups at random. Group C (control group), this group patients treated only treatment In T (test group) used OLP cases. applications four times per day an alternate sequence (in T). schedule continuous for 4 weeks one visit weekly a follow-up. Oral hygiene measures strictly total elimination plaque calculus deposits removal they implement inflammation intra-orally and ‎exaggerate together distribution signs lesions. Each underwent pain assessment sign score recordings both before after strategies. Results: results all reported no unwanted reactions or complications Both significant decrease scale over time shown within intragroup findings. experienced significantly higher reduction (starting weeks) three compared C. Conclusions: Based on data presented study, is efficient terms decreasing values (Clinical Trials.gov registration number NCT06060301).

Language: Английский

Citations

0
Consider topical superpotent corticosteroids for oral lichen planus; reserve systemic therapy for severe disease DOI

Esther Kim,

Simon Fung

Drugs & Therapy Perspectives, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Impact of oral precancerous lesions on oral cancer development in patients with oral lichen planus: a retrospective cohort study of 318 oral lichen planus patients DOI Creative Commons
Yu-Cheng Chu,

Pei-Yu Lin,

Wan‐Ting Huang

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: March 6, 2025

Oral lichen planus (OLP) has been implicated as a potential risk factor for oral cancer. This study aimed to investigate the long-term determinants of cancer development following diagnosis OLP. A retrospective cohort 318 patients with histopathologically confirmed OLP was conducted at tertiary medical center from 1995 2018. Patients were categorized into two groups based on presence or absence precancerous lesions (OPLs). Baseline characteristics, underlying conditions, and lifestyle factors compared between groups. The hazard ratio (HR) 10-year cumulative estimated using logistic regression Kaplan-Meier analysis, respectively. In our cohort, total 33 (10.38%) diagnosed After adjusting confounders, OPLs (HR, 2.98), age over 50 years 4.36), chronic kidney disease 4.46), alcohol consumption 4.23) emerged independent in (P < 0.05). current indicates that OPLs, including histologically verrucous hyperplasia varying degrees dysplasia, is associated an increased Further research needed elucidate molecular mechanisms linking OLP, OPL, occurrence.

Language: Английский

Citations

0
Logistic regression and covariate-balanced matching analysis of lichen planus and inflammatory gastrointestinal disorders DOI
Amritpal Kooner,

Rawle A. Sekhon,

Jarett Anderson

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 19, 2025

Language: Английский

Citations

0