Premenstrual syndrome: new insights into etiology and review of treatment methods

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Premenstrual syndrome (PMS) is a common disorder affecting women of reproductive age, with an estimated global prevalence 47.8%, severe symptoms occurring in 3-8%, significantly daily functioning. GABA conductance and changes neurosteroid levels, particularly allopregnanolone, are suspected to play substantial role the disorder’s etiology. In this paper, we provide overview recent reports on etiology recognized therapeutic approaches, encompassing both pharmacological non-pharmacological interventions. Our examination includes studies SSRIs, hormonal agents, neurosteroids, supplementation, roles. We aim determine most favorable treatment regimen by comparing medication effects alternative methods. The PMS crucial for enhancing quality life affected women. Medications used should be individually selected achieve best effect, considering clinical situation patients.

Language: Английский

---

Established and emerging GABAA receptor pharmacotherapy for epilepsy

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 21, 2024

Drugs that modulate the GABA A receptor are widely used in clinical practice for both long-term management of epilepsy and emergency seizure control. In addition to older medications have well-defined roles treatment epilepsy, recent discoveries into structure function led development newer compounds designed maximise therapeutic benefit whilst minimising adverse effects, whose position within pharmacologic armamentarium is still emerging. will remain a cornerstone foreseeable future and, this article, we provide an overview mechanisms efficacy established emerging pharmacotherapies.

Language: Английский

---

The emergence of antidepressant drugs targeting GABAA receptors: A concise review

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 228, P. 116481 - 116481

Published: Aug. 13, 2024

Depression is among the most common psychiatric illnesses, which imposes a major socioeconomic burden on patients, caregivers, and public health system. Treatment with classical antidepressants (e.g. tricyclic selective serotonine reuptake inhibitors), primarily affect monoaminergic systems has several limitations, such as delayed onset of action moderate efficacy in relatively large proportion depressed patients. Furthermore, depression highly heterogeneus, its different subtypes, including post-partum depression, involve distinct neurobiology, warranting differential approach to pharmacotherapy. Given these shortcomings, need for novel that are superior faster fully justified. The development market introduction rapid-acting accelerated recent years. Some new act through GABAergic In this review, we discuss discovery, efficacy, limitations treatment classic antidepressants. We provide detailed discussion neurotransmission, special focus GABA

Language: Английский

---

Leveraging research into sex differences and steroid hormones to improve brain health

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

---

Prämenstruelle dysphorische Störung

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

---

Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1080 - 1080

Published: March 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Language: Английский

---

Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 243, P. 106590 - 106590

Published: July 23, 2024

Neuroactive steroids (i.e., sex steroid hormones and neurosteroids) are important physiological regulators of nervous function potential neuroprotective agents for neurodegenerative psychiatric disorders. Sex is an component such effects. However, even if fluctuations in hormone level during the menstrual cycle associated with neuropathological events some women, neuroactive pattern brain across ovarian has been poorly explored. Therefore, we assessed levels pregnenolone, progesterone, its metabolites dihydroprogesterone, allopregnanolone isoallopregnanolone), dehydroepiandrosterone, testosterone dihydrotestosterone, 3α-diol 17β-estradiol) rat to determine whether their plasma similar those occurring central hippocampus cerebral cortex) peripheral sciatic nerve) system. Data obtained indicate that these molecules generally does not fully reflect In addition, levels, identical between two regions nerves. Indeed, exception all other here showed peculiar regional differences fluctuation system estrous cycle. These observations may have diagnostic therapeutic consequences influenced by

Language: Английский

---

Childhood adversity predicts stronger premenstrual mood worsening, stress appraisal and cortisol decrease in women with Premenstrual Dysphoric Disorder

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 2, 2023

Background Lifetime traumatic events are prevalent in women with Premenstrual Dysphoric Disorder (PMDD) and predict stronger premenstrual symptom intensities. Less is known about the unique effects of childhood adversity on PMDD. This study aims to investigate menstrual cycle related course mood, stress appraisal cortisol activity over time – by controlling for recent stressful life cyclicity these outcomes. Methods Fifty-two PMDD completed questionnaires during past 12 months. Momentary negative positive affect, appraisal, saliva-cortisol were assessed within an Ambulatory Assessment (AA) design four consecutive days both follicular late luteal phase. AA was repeated after five months, resulting two measurement bursts. Results Women showed expected variations mood whereby weakened time. No identified. Higher linked increases affect decreases from toward higher exhibited lower levels phase compared whereas no such found adversity. Conclusion Childhood appears show independent deteriorating worsening The observed may point different neuroendocrine subtypes relation trauma requires further systematic research.

Language: Английский

---

Endocrinological Treatment Targets for Depressive Disorder

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 25

Published: Jan. 1, 2024

Language: Английский

---

Premenstrual Dysphoric Disorder and Rumination

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 1, 2024

Language: Английский

---