Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 198, P. 107131 - 107131
Published: Nov. 16, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 5, 2024
Abstract Periodontitis, one of the most prevalent dental diseases, causes loss bone and gum tissue that hold teeth in place. Several bacteria, commonly present clinically healthy oral cavities, may induce perpetuate periodontitis when their concentration rises gingival sulcus. Antibacterial effect against various Gram-negative Gram-positive including pathogenic drug-resistant ones, has been shown for several distinct transient metal oxide NPs. Therefore, NPs be used biomedicine to treat periodontal problems nanotechnology inhibit development microorganisms. Instead using harmful chemicals or energy-intensive machinery, biosynthesis nanoparticles (NPs) suggested. To produce NPs, ideal technique is “Green” synthesis because its low toxicity safety human health environment. Gold (AuNPs) appear less toxic mammalian cells than other nanometals antibacterial activity not dependent on reactive oxygen species (ROS). AgNPs also possess chemical stability, catalytic activity, superior electrical thermal conductivity, name a few advantageous characteristics. It was observed zinc (ZnO) copper (Cu) exhibited discernible inhibitory effects gram-positive gram-negative bacterial strains, respectively. ZnO demonstrated bactericidal microorganisms responsible periodontitis. Medications containing magnetic are highly effective multidrug-resistant fungal infections. The titanium dioxide (TiO 2 ) implicated elevating salivary peroxidase individuals diagnosed with chronic Furthermore, specific metallic have potential enhance antimicrobial efficacy treatments combined. these as well only some metals oxides synthesized environmentally friendly ways therapeutic benefits Graphical
Language: Английский
Citations
60
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 25, 2024
Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical
Language: Английский
Citations
36
Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)
Published: April 18, 2024
Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose eventually falling out. Timely identification has crucial role preventing controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is hunt for alternative diagnostic monitoring methods due progress technology. Various biomarkers have been assessed using multiple bodily fluids sample sources. Furthermore, conventional categorization factors do not provide significant insights into present disease activity, severity amount tissue damage, future development, responsiveness treatment. In recent times, growing utilization nanoparticle (NP)-based detection strategies create quick efficient assays. Every single one these platforms leverages distinct characteristics NPs identify Plasmonic include metal NPs, quantum dots (QDs), carbon base nanozymes, exceptionally potent light absorbers scatterers. These find application labeling, surface-enhanced spectroscopy, color-changing sensors. Fluorescent function photostable sensitive instruments capable labeling various biological targets. article presents comprehensive summary latest developments effective detect
Language: Английский
Citations
27
Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(3), P. 688 - 721
Published: Feb. 3, 2024
Language: Английский
Citations
23
Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)
Published: June 26, 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, affects large regions of Asia, Southwestern Southeastern Europe, Africa. CCHFV can produce symptoms, including no specific clinical mild to severe or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, cheap technology, biosensors, must be designed developed detect The goal this article offer overview modern laboratory available as well other innovative detection methods such biosensors CCHFV, the benefits limits assays. confirmed cases CCHF managed with symptomatic assistance general supportive care. This study examined various treatment modalities, their respective limitations developments, immunotherapy antivirals. Recent biotechnology advancements availability suitable animal models have accelerated development vaccines by substantial margin. We range potential in research, comprising nucleic acid, viral particles, inactivated, multi-epitope vaccines, present obstacles developments field. Thus, purpose review comprehensive summary endeavors dedicated advancing diagnostic, therapeutic, preventive strategies infection anticipation forthcoming hazards.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.
Language: Английский
Citations
0
Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36
Published: Jan. 30, 2025
The mouth cavity is the second most complex microbial community in human body. It composed of bacteria, viruses, fungi, and protozoa. An imbalance oral microbiota may lead to various conditions, including caries, soft tissue infections, periodontitis, root canal peri-implantitis (PI), pulpitis, candidiasis, denture stomatitis. Additionally, several locally administered antimicrobials have been suggested for dentistry surgical non-surgical applications. main drawbacks are increased antimicrobial resistance, risk upsetting natural microbiota, hypersensitivity responses. Because their unique physiochemical characteristics, nanoparticles (NPs) can circumvent antibiotic-resistance mechanisms exert action via a variety new bactericidal routes. anti-microbial properties, carbon-based NPs becoming more effective antibacterial agents. Periodontitis, PI, dentin other dental diseases among conditions that be treated using carbon (CNPs) like graphene oxide dots. outline scientific development multifunctional CNPs concerning disorders will given before talking about significant influence on health. Some these illnesses include pulp disorders, PI. We also review remaining research application barriers possible future problems.
Language: Английский
Citations
0
Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60
Published: Dec. 19, 2024
Periodontitis (PD) is a chronic gum illness that may be hard to cure for number of reasons, including the fact no one knows what causes it, side effects anti-microbial treatment, and how various kinds bacteria interact with another. As result, novel therapeutic approaches PD treatment must developed. Additionally, supplementary antibacterial regimens, local systemic medication administration chemical agents, are necessary deep pockets assist mechanical debridement tooth surfaces. our knowledge periodontal disease drug delivery systems (DDSs) grows, new targeted like extracellular vesicles, lipid-based nanoparticles (NPs), metallic NPs, polymer NPs have been These aim improve targeting precision treatments while reducing antibiotics. Nanozymes, photodermal therapy, traditional therapies all reviewed in this research. Medicinal herbs, antibiotics, photothermal nanozymes, conventional examined After that, we key features many innovative DDSs they worked therapy. Finally, discussed advantages disadvantages these DDSs.
Language: Английский
Citations
3
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105922 - 105922
Published: June 29, 2024
Language: Английский
Citations
2
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 198, P. 107131 - 107131
Published: Nov. 16, 2024
Language: Английский
Citations
0